Abstract: Disclosed is a field detection device designed to be connected to at least one access point of a fieldbus network via at least one interface. The field detection device is designed to initiate or execute, for each of at least two connection protocols, an associated query in at least one fieldbus segment of the fieldbus network and to detect which field devices and fieldbus components in said at least one fieldbus segment can be accessed via the connection protocol in question. Furthermore, the field detection device is designed to provide a connection directory in which at least one connection protocol is specified for each field device and for each fieldbus component of a set of field devices and fieldbus components of the at least one fieldbus segment, by means of which connection protocol the field device in question or the fieldbus component in question can be accessed.

Abstract: An actuator for aviation applications, in particular for adjusting rotor blades in a helicopter, may include an electromechanical drive assembly connected to an output drive via a downstream transmission, where the drive assembly is divided into sub-drives that can be operated independently, and where at least two sub-drives are spatially separated from one another in that the transmission is placed between these sub-drives. The transmission may include at least two harmonic gearings coupled to one another by at least one first coupling element, where a first harmonic gearing is located inside a non-rotating first housing, where a second harmonic gearing is located inside a rotating second housing, and where the second housing is connected to the output drive.

Abstract: The present disclosure relates to an ophthalmological patient interface for application to an eye of a person, the ophthalmological patient interface comprising a coupling portion configured to be arranged on an application head of an ophthalmological laser treatment system, wherein the ophthalmological patient interface further comprises an eye fixation portion configured to be arranged on the eye, wherein the eye fixation portion comprises a cornea contacting element, configured to contact at least partially the cornea of the eye, and a sclera contacting element, configured to contact at least partially the sclera of the eye, wherein the cornea contacting element and the sclera contacting element define a rotationally asymmetric contact surface configured to contact the eye.

Abstract: The present disclosure relates to an ophthalmological laser treatment system for treatment of tissue of an eye comprising an ophthalmological laser treatment device comprising a base station having a treatment laser source configured to generate a treatment laser beam, an arm and an application head, wherein the ophthalmological laser treatment system further comprises an ophthalmological patient interface with a cornea contacting element, and a sclera contacting element, wherein the cornea contacting element and the sclera contacting element define a rotationally asymmetric contact surface configured to contact the eye, wherein the ophthalmological patient interface comprises a through opening, which is configured to enable the treatment laser beam from the application head to pass through the ophthalmological patient interface to penetrate a target volume of tissue of the eye.

Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.

Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.

Abstract: A method, a device, and a corresponding computer program product for calculating (optimizing) and producing a spectacle lens with the aid of a semi-personalized eye model.

Abstract: An igniter for a gas generator comprises a pole body (14) having at least one connection pin (16, 18), a retaining ring (20) and an insulation ring (22), wherein the insulation ring (22) spaces apart the at least one connection pin (16, 18) from the retaining ring (20) and electrically insulates it relative to the same. The retaining ring (20) consists of a metal and the insulation ring (22) consists of a plastic.

Abstract: An electric motor (1), in particular, an external rotor motor, has a stator (10) with a stator core (11), a non-rotatably attached shaft (20), that extends in the axial direction (A) of the motor, and a rotor bell (30), rotatably arranged relative to the non-rotatable shaft (20). The rotor bell (30) has cooling ribs in an open, spoke-like design rotatably mounted on the shaft (20) by at least one first stator-side bearing shield (31). A cooling device (40) is arranged between and connects the shaft (20) and the stator core (11). The cooling device (40) has a plurality of axial flow openings (41) arranged in the circumferential direction that causes cooling when the motor rotates during operation.

Abstract: A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin and/or with long-acting insulin/insulin derivates where appropriate.

Abstract: A method, a device, and a corresponding computer program product for calculating (optimizing) and producing a spectacle lens with the aid of a semi-personalized eye model. In one approach, the method includes providing personalized refraction data of at least one eye of the spectacles wearer; establishing a personalized eye model in which at least the parameters: shape of an anterior corneal surface of a model eye; a cornea-lens distance; parameters of the lens of the model eye; and lens-retina distance are established using personalized measured values for the eye of the spectacles wearer, and/or using standard values, and/or using the provided personalized refraction data, such that the model eye has the provided personalized refraction data, wherein at least the establishment of the lens-retina distance takes place via calculation.

Abstract: The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents comprising engineered immunoglobulin (Ig) alleles. Such engineered alleles, wherein an Ig light chain CL exon [C? or C? (C?1, C?2 or C?3)] is incorporated into the Ig heavy chain locus, are capable of producing heavy chain-only antibodies as a single chain VH antibody (scVHAb) or heavy chain antibody (HCAb) comprising two extended scVHAbs. The scVHAb comprises an antigen-binding part consisting of a VH domain and the immunoglobulin constant domains CL, which is either C? or C?, and CH1, in the order from N-terminus to C-terminus: VH-L1-CL-L2-CH1, wherein L1 and L2 are each, independently, peptidic linkers; and wherein CL is paired with CH1 through beta-sheet contact thereby obtaining a CL/CH1 dimer.

Abstract: Transgenic mammals that express bovine-based immunoglobulins are described herein, including transgenic rodents that express bovine-based immunoglobulins for the development of bovine therapeutic antibodies.

Abstract: Stator of an electric machine, wherein the stator comprises a stator yoke, wherein stator teeth for receiving electrical windings are disposed on the stator yoke, wherein one tooth shoe is disposed on the radial end of each of the stator teeth, wherein the tooth shoe is configured as a separately manufactured component, wherein the tooth shoe 4 upon attaching the electric winding to the stator tooth is able to be plugged in a force-fitting and/or form-fitting manner onto the stator tooth, wherein the connection between the tooth shoe and the stator tooth is configured by means of dovetail joint.

Abstract: Stator, in particular a stator manufactured from punch bundled dynamo sheets, for an external rotor and/or an internal rotor motor of an electric machine, comprising a stator yoke, a plurality of stator teeth, as well as in each case one stator groove lying between two stator teeth, wherein at least one heat conducting pipe for cooling the stator is in each case incorporated in the stator groove.

Abstract: Stator for an electric motor, comprising the following components: at least one first basic stator, wherein the basic stator is formed from at least two basic stator modules which in an annular manner are disposed in series, wherein the first basic stator module conjointly with the at least second basic stator module forms a stator yoke, wherein each of the basic stator modules configures a stator tooth that extends radially from the stator yoke; at least one tooth shoe, wherein the tooth shoe is connected to the stator tooth in a force-fitting and/or form-fitting manner by means of a tongue-and-groove connection, in particular by means of a dovetail joint; at least one electric winding; at least one insulation which electrically isolates the basic stator from the winding, at least one expansion means; as well as at least one cooling device, wherein the components are able to be combined in a modular manner.

Abstract: An external rotor motor (1) has a stator (10) with a stator lamination (11), a shaft (20) and a rotor bell (30). The shaft (20) is attached in a non-rotatable manner and extends in the axial direction (A) of the motor. The rotor bell (30) is arranged such that it can rotate relative to the non-rotatable shaft (20). The rotor bell (30) is rotatably mounted on the shaft (20) by at least one first stator-side bearing shield (31) and a second rotor-side bearing shield (32). The stator (10) has a modular construction with a plurality of individual teeth (12) to attach the stator windings (16). The individual teeth (12) are attached to one another in the direction of rotation and/or to a central stator body (17) by a respective fastening contour (15, 18, 18a, 19, 19a), through which a fastening pin (15) extends.

Abstract: The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents comprising engineered immunoglobulin (Ig) alleles. Such engineered alleles, wherein an Ig light chain CL exon [C? or C? (C?1, C?2 or C?3)] is incorporated into the Ig heavy chain locus, are capable of producing heavy chain-only antibodies as a single chain VH antibody (scVHAb) or heavy chain antibody (HCAb) comprising two extended scVHAbs. The scVHAb comprises an antigen-binding part consisting of a VH domain and the immunoglobulin constant domains CL, which is either C? or C?, and CH1, in the order from N-terminus to C-terminus: VH-L1-CL-L2-CH1, wherein L1 and L2 are each, independently, peptidic linkers; and wherein CL is paired with CH1 through beta-sheet contact thereby obtaining a CL/CH1 dimer.

Abstract: A stator (1) for an electric motor has a modular stator body (2) with at least two stator cores (10, 20) arranged axially in series. Each core (10, 20) is form from a plurality of stacked electrical laminations (11, 21). This forms winding poles (16, 26) with radially extending winding webs (17, 27). The stator cores (10, 20) each have a separate overmolding (U1, U2).