Abstract: A stator (1) for an electric motor has a modular stator body (2) with at least two stator cores (10, 20) arranged axially in series. Each core (10, 20) is form from a plurality of stacked electrical laminations (11, 21). This forms winding poles (16, 26) with radially extending winding webs (17, 27). The stator cores (10, 20) each have a separate overmolding (U1, U2).

Abstract: A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt thereof, and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin where appropriate.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: A transgenic mouse that is engineered by one or more genetic modifications that delete endogenous Adam6a and Adam6b genes in a male mouse, which mouse comprises in its genome only one exogenous Adam6 transgene, and expresses an ADAM6 protein comprising at least 90% sequence identity to SEQ ID NO:1 or SEQ ID NO:2, which Adam6 transgene is functional in a male mouse.

Abstract: An igniter for a gas generator comprises a pole body (14) having at least one connection pin (16, 18), a retaining ring (20) and an insulation ring (22), wherein the insulation ring (22) spaces apart the at least one connection pin (16, 18) from the retaining ring (20) and electrically insulates it relative to the same. The retaining ring (20) consists of a metal and the insulation ring (22) consists of a plastic.

Abstract: A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin and/or with long-acting insulin/insulin derivates where appropriate.

Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.

Abstract: Transgenic mammals that express canine-based immunoglobulins are described herein, including transgenic rodents that express canine-based immunoglobulins for the development of canine therapeutic antibodies.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: In a method for creating a design of a prescription surface of a multifocal lens, in particular for a progressive spectacle lens, at first data and second data for describing at least one aberration of an eye of a proband for a first situation of use and a second situation of use, respectively, are obtained, and then a first set of parameters and a second set of parameters of a predetermined prescription surface equation are determined from the first and second data, wherein the prescription surface equation is assigned to a first reference point of the prescription surface for the first set of parameters, and is assigned to a second reference point of the prescription surface for the second set of parameters.

Abstract: The invention relates to an electric motor, particularly an “external rotor motor”, comprised of a stator housing and a rotor housing which is rotatable with respect to the stator housing, wherein the rotor housing has a cooling ring disposed on its side which axially faces the stator housing, wherein the stator housing and the cooling ring are each provided with a plurality of first and second cooling fins (the second cooling fins also being referred to as “cooling ribs”) which face each other axially and are disposed so as to be distributed in the respective circumferential directions, which fins/ribs collaborate in flow technology when the rotor housing is in rotating operation; wherein, in an axial plan view, the first cooling fins extend radially outwardly, and the second cooling fins (the cooling ribs) are V-shaped and point in the circumferential direction, wherein a rotary relative movement of the first and second cooling fins (the cooling fins and the cooling ribs) generates a cooling air stream, at

Abstract: A method, a device, and a corresponding computer program product for calculating (optimizing) and producing a spectacle lens with the aid of a semi-personalized eye model. In one approach, the method includes providing personalized refraction data of at least one eye of the spectacles wearer; establishing a personalized eye model in which at least the parameters: shape of an anterior corneal surface of a model eye; a cornea-lens distance; parameters of the lens of the model eye; and lens-retina distance are established using personalized measured values for the eye of the spectacles wearer, and/or using standard values, and/or using the provided personalized refraction data, such that the model eye has the provided personalized refraction data, wherein at least the establishment of the lens-retina distance takes place via calculation.

Abstract: A device for determining the distance of an eye of a user from the image capturing device is disclosed. The device includes a lighting device that is arranged at a specified position relative to the image capturing device and is designed to generate at least one specular light reflection, which has a linear portion, on the cornea of the eye of the user. The device also includes an image capturing device designed to capture at least one image of the specular light reflection in the region of the cornea of the at least one eye of the user. A distance determining device is designed to ascertain data relating to the distance between two specified points of the light reflection and the curvature of the at least one linear portion of the light reflection in the captured image and the distance of the eye from the image capturing device.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents comprising engineered immunoglobulin (Ig) alleles. Such engineered alleles, wherein an Ig light chain CL exon [C? or C? (C?1, C?2 or C?3)] is incorporated into the Ig heavy chain locus, are capable of producing heavy chain-only antibodies as a single chain VH antibody (scVHAb) or heavy chain antibody (HCAb) comprising two extended scVHAbs. The scVHAb comprises an antigen-binding part consisting of a VH domain and the immunoglobulin constant domains CL, which is either C? or C?, and CH1, in the order from N-terminus to C-terminus: VH-L1-CL-L2-CH1, wherein L1 and L2 are each, independently, peptidic linkers; and wherein CL is paired with CH1 through beta-sheet contact thereby obtaining a CL/CH1 dimer.

Abstract: A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt thereof, and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin where appropriate.

Abstract: Optimizing and producing a lens by defining an individual eye model, in which a shape of a corneal front surface of a model eye, and a reference aberration at an evaluation surface within the model eye are defined based on individual measurement values for the lens wearer's eye, on standard values, or based on provided individual refraction data; specifying first and second surfaces for the lens to be optimized; determining the path of a main ray through a visual point a surface of the lens into the model eye up to the evaluation surface; evaluating an aberration of a wavefront propagating along the main ray and resulting from a spherical wavefront incident on the first surface of the lens at the evaluation surface in comparison to the reference aberration; and iteratively varying the surface of the lens until the evaluated aberration corresponds to a predetermined target aberration.

Abstract: An apparatus for determining optical parameters of a user with spectacles arranged in the use position on the head of the user includes at least one projection device designed and arranged for marking a partial region of the head of the user and/or of the spectacles of the user with a light projection; at least one image recording device designed and arranged for generating image data at least from the marked partial region of the head of the user and/or of the spectacles of the user; and a data processing device with a user data determining device, which is designed to determine user data from the marked partial region of the head and/or of the spectacles on the basis of the generated image data, wherein the user data comprise spatial information in the three-dimensional space of points of the partial region of the head and/or of the spectacles, and a parameter determining device, which is designed to determine optical parameters of the user on the basis of the user data.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: A stator (1) for an electric motor has a modular stator body (2) with at least two stator cores (10, 20) arranged axially in series. Each core (10, 20) is form from a plurality of stacked electrical laminations (11, 21). This forms winding poles (16, 26) with radially extending winding webs (17, 27). The stator cores (10, 20) each have a separate overmolding (U1, U2).