Abstract: The present invention relates to compounds of formula I wherein R1a to R1c, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract: The present invention relates to compounds of formula I wherein R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract: In a device for dosing and transporting dry urea, e.g., for implementing the SCR method in a motor vehicle, the device includes a storage vessel containing the dry urea in the form of pellets, the wall of the storage vessel having an opening to which a transport line is connected on the outer side. The device also includes a compressed air nozzle which is arranged inside the storage vessel at a distance from the opening, is oriented towards the opening, and may be supplied with compressed air, and a portioning element having an upper side oriented towards the inside of the storage vessel and a lower side opposite the wall of the storage vessel. At least one continuous channel having a larger cross section than the dimensions of the pellets connects the upper side and the lower side in order to form at least one receiving element for the pellets.

Abstract: A method of producing a progressive spectacle glass by defining an ordering value for the average use value in the far reference point of the progressive spectacle glass, calculating the progressive spectacle glass while taking into account a calculation value of the average use value in the far reference point, the calculation value having a negative desired refraction deviation between 0.03 dpt and 0.2 dpt with respect to the ordering value in the far reference point, and producing the calculated progressive spectacle glass.

Abstract: The present invention relates in summary to a method for checking and/or determining user data of a spectacle lens user comprising the steps of:—providing (S1) subjective data of a spectacle lens user, wherein the subjective data comprise at least subjective refraction data;—providing (S2) objective refraction data of the spectacle lens user;—comparing (S3) at least one subset of the subjective refraction data with at least one subset of the objective refraction data and determining a comparison result;—matching (S3) at least the subset of the subjective refraction data to the objective refraction data on the basis of the comparison result under the assumption that the comparison result fulfills at least one predetermined comparison condition, otherwise maintaining at least the subset of the subjective refraction data and/or—providing a message containing the comparison result, and to a further method, a computer program product and two devices for checking and/or determining user data.

Abstract: The invention relates particularly to a spectacle lens having a first and a second surface, wherein at least the first surface of the spectacle lens has a major portion zone and at least one prism zone. The major portion zone of the first surface, together with the opposing second surface of the spectacle lens, forms a major portion of the spectacle lens, which is designed for vision in at least a predetermined distance. The prism zone of the first surface, together with the opposing second surface of the spectacle lens, forms a prism portion, which is designed and arranged such that an optical image of a display is formed at a predetermined virtual distance in front of the eyes of the spectacle wearer. The invention further relates to spectacles, which comprise the spectacle lens, and to a method and apparatuses for calculating or optimizing and producing the spectacle lens.

Abstract: Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.

Abstract: The invention relates to a method for producing a progressive spectacle lens and to a corresponding apparatus, a computer program product, a storage medium and to the use of a progressive spectacle lens. The invention also relates to a method for producing a progressive spectacle lens for correcting defective vision of a spectacle wearer, comprising the following steps: the vertical and/or the horizontal spatial position of a distance reference point and/or a near reference point is specified or determined in accordance with individual data of the spectacle wearer; the spectacle lens is optimized or calculated such that the required dioptric effect of the spectacle lens is obtained in the individually determined distance reference point and/or the near reference point.

Abstract: The invention relates to a device (10) for determining the optical parameters of a user comprising: at least two image recording devices (14, 16), which are configured and arranged to respectively generate image data of at least sub-sections of the head of the user (30); a data processing unit comprising a user data determination device, which is configured to use the generated image data to determine user data relating to at least one sub-section of the head, or at least one sub-section of a system placed on the head that supports a pair of glasses (38) of the user (30) in a normal position of wear, the user data containing the three-dimensional location information of predetermined points in the head sub-section or the system sub-section and comprising a parameter determination unit, which is configured to determine at least some of the optical parameters of the user (30); a data output device, which outputs at least some of the determined optical parameters of the user (30).

Abstract: A method for automatic sleeve filling of a winding shaft on roll cutting and winding machines is provided in which, in an exemplified embodiment, in a first step at least two empty winding sleeves are slid onto a free end of a winding shaft so that the winding sleeves are adjacent to one another, in a second step the last winding sleeve slid on by a freely positionable fork piece of a freely programmable draw-off plate along the winding shaft is slid over the winding shaft until the last winding sleeve has reached a predetermined position, in a third step the next-to-last winding sleeve slid on is grasped by tongs freely positionable along the winding shaft and is slid over the winding shaft to the point where in a fourth step the fork piece can dip into the gap produced by the tongs so that the next-to-last winding sleeve is positionable along the winding shaft by the fork piece.

Abstract: The invention relates to a method, a computer program product and a system for designing or producing a spectacle lens for a spectacle wearer. Said method consists of the following steps: individual user data or application data of the spectacle wearer is obtained; the design concept for the spectacle lens having a plurality of evaluation points is determined; a main beam path through the plurality of evaluation points is determined; a local wavefront is specified for each of the main beams in the surroundings of the respective main beam; optical properties of the spectacle lens are determined on the evaluation points by determining an influence of the spectacle lens on the local wavefronts in the surroundings of the respective evaluation point; and the design concept is evaluated in accordance with the determined optical properties and the individual user data.

Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract: The present invention relates to the use of cyclic peptides, in particular of vioprolides for the treatment and prevention of various diseases, disorders and conditions. In particular, the present invention provides compounds useful in enhancing and/or supporting interferon type I1 like interferon alpha or interferon beta, treatment or prevention of diseases, disorders or conditions. Further, the present invention relates to new pharmaceutical compositions comprising specific cyclic peptides, in particular, vioprolides, and type I interferon and its use in the treatment of various diseases, in particular, in the treatment or prevention of infectious diseases, cancers etc. Finally, the present invention provides methods for preventing or treating diseases, disorders or conditions susceptible to type I interferon treatment or prevention.

Abstract: Use of a protein of the SDF-1-family for the manufacturing of a medicament for the improvement of the plasticity and/or regeneration of axons upon their lesion.

Abstract: A device for the reduction of nitrogen oxides in the exhaust gas of internal combustion engines has a thermolysis reactor (10). In the thermolysis reactor (10), urea is converted into ammonia and isocyanic acid by means of the supply of heat. In a preferred embodiment of the invention, the thermolysis reactor (10) is arranged within the exhaust gas duct (26) and is thermally coupled to an oxidation catalytic converter (30) which is connected upstream of the thermolysis reactor (10) in the flow direction. As a result of the exothermic reactions taking place in the oxidation catalytic converter (30), it is possible for heating of the thermolysis reactor (10) to take place. In order to further increase the temperature, it is possible for fuel to be injected into the oxidation reactor (30) by means of a fuel supply device. The fuel is burned catalytically in the oxidation catalytic converter (30).

Abstract: The invention relates to a spectacle lens device comprising at least one electrically adaptive area, wherein optical properties of the spectacle lens device can be controlled in an electric manner. The spectacle lens device is configured in such a manner that the optical properties of a predetermined or predeterminable control area can be controlled in an electrical manner which is essentially independent from the optical properties in a surrounding area. The invention also relates to the control area and to the surrounding area, respectively, about a partial area of the electrically adaptive area. The control area and the surrounding area do not a common area. The invention further relates to a pair of spectacles comprising a spectacle lens device, to the use of the inventive spectacle lens device and also to a method for operating an electrically adaptive area.

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.

Abstract: A transmitting optical element (33, 37) adapted for use in an objective for a microlithographic projection exposure apparatus is composed of a polycrystalline material (100), with the polycrystalline material (100) having crystallites (102) with a cubic crystal structure, and with the mean crystallite size of these crystallites (102) being at least (0.5) micrometers, and at most (100) micrometers.

Abstract: Compounds of formula I their manufacture, pharmaceutical compositions containing them and their use as medicaments.

Abstract: The invention relates to a device (10) for determining the optical parameters of a user comprising: at least two image recording devices (14, 16), which are configured and arranged to respectively generate image data of at least sub-sections of the head of the user (30); a data processing unit comprising a user data determination device, which is configured to use the generated image data to determine user data relating to at least one sub-section of the head, or at least one sub-section of a system placed on the head that supports a pair of glasses (38) of the user (30) in a normal position of wear, the user data containing the three-dimensional location information of predetermined points in the head sub-section or the system sub-section and comprising a parameter determination unit, which is configured to determine at least some of the optical parameters of the user (30); a data output device, which outputs at least some of the determined optical parameters of the user (30).