Abstract: The present disclosure generally relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019 (which has been termed and may be referred to herein as “COVID-19”, “2019-nCoV”, or the “2019 novel coronavirus”. The disclosure relates to immunogenic polypeptides and the uses thereof, particularly in vaccine compositions. The disclosure also relates to nucleic acids, vectors, and cells which express the polypeptides and the uses thereof. The polypeptides more specifically comprise an agretope predicted to be a ligand of HLA class I and/or HLA class II MHC molecules, as well as an epitope that is predicted to be recognized by T-cells in the context of MHC class I and/or class II molecules.

Abstract: The present invention includes a method of obtaining a biological sample from the nose, nasal cavities, nasal pharynx, oral mucosa, or saliva of a subject to be used for detection of a virus (e.g., a SARS-Co V-2 virus), and kits for performing the method.

Abstract: Force transducers for use in electrostatic drivers, including electrostatic drivers that can be utilized in loudspeaker systems that utilize drivers having a magnetic negative spring (MNS) (such as reluctance assist drivers (RAD) and permanent magnet crown (PMC) drivers). The electroacoustic drivers having the force transducers can be used at all audio frequencies, including subwoofer frequencies.

Abstract: The present disclosure generally relates to a T-cell epitope compounds and compositions effective against African Swine Fever Virus (“ASFV”) and related diseases. Such T-cell epitope compounds and compositions include immunogenic T-cell epitope polypeptides (including concatemeric polypeptides and chimeric or fusion polypeptides), as well as nucleic acids, plasmids, vectors, and cells which express the polypeptides, pharmaceutical compositions, and vaccines, and the uses thereof. The present disclosure is particularly suited to produce vaccines for non-human animals, particularly for vaccinating swine against ASFV infection and related diseases.

Abstract: A pump panel training device is provided and includes a plurality of simulated gages operable to imitate gages upon a fire truck pump panel, a plurality of simulated controls operable to imitate controls upon the fire truck pump panel, and a simulated water hose operable to imitate one of water temperature changes, water temperature pressure, and water hose vibration for the fire truck pump panel.

Abstract: Electroacoustic drivers that can be utilized in loudspeaker systems that utilize drivers having a magnetic negative spring (MNS) (such as reluctance assist drivers (RAD) and permanent magnet crown (PMC) drivers). The electroacoustic drivers can be used at all audio frequencies, including subwoofer frequencies. The magnetic negative springs of the electroacoustic drivers can cancel, or partially cancel, the large pressure forces on a sound panel (of an audio speaker) so that substantial subwoofer notes can be efficiently and cost effectively produced in small/portable speakers. The electroacoustic drivers can include a stabilizing/centering mechanism to overcome the destabilizing forces of a MNS that are too large for a voice coil alone to produce.

Abstract: A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system.

Abstract: The present disclosure generally relates to novel Tregitope-blood component conjugates and modified polypeptides comprising Tregitopes, with said modified peptides being capable of reacting with blood components to form such Tregitope-blood component conjugates. In aspects, the Tregitope-blood component conjugates include a blood component which acts as a carrier protein (e.g., albumin), and further include a modified polypeptide comprising one or more regulatory T cell epitopes (termed “Tregitopes”), the polypeptide having been modified by attaching a reactive moiety to the polypeptide that is capable of forming a bond (e.g., a covalent linkage) with a reactive functionality on the blood component. The present disclosure also relates to methods of using said Tregitope-blood component conjugates and modified polypeptides comprising Tregitopes in the treatment and prevent of autoimmune disorders, such as type 1 diabetes.

Abstract: The present disclosure relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019. The disclosure relates to immunogenic polypeptides (including concatemeric polypeptides, hybrid Ii-key constructs, and chimeric or fusion polypeptides as disclosed herein) and the uses thereof, particularly in vaccine compositions. The disclosure also relates to nucleic acids, vectors, and cells which express the polypeptides and the uses thereof. The polypeptides of the invention more specifically comprise an agretope predicted to be a ligand of HLA class I and/or HLA class II MHC molecules, as well as an epitope that is predicted to be recognized by T-cells in the context of MHC class I and/or class II molecules.

Abstract: An example device includes a plurality of computational memory banks. Each computational memory bank of the plurality of computational memory banks includes an array of memory units and a plurality of processing elements connected to the array of memory units. The device further includes a plurality of single instruction, multiple data (SIMD) controllers. Each SIMD controller of the plurality of SIMD controllers is contained within at least one computational memory bank of the plurality of computational memory banks. Each SIMD controller is to provide instructions to the at least one computational memory bank.

Abstract: This disclosure describes a kit comprising component for removing, replacing, and/or sealing toilet parts. In some embodiments, the kit comprises a flush valve assembly, fill valve assembly, a handle assembly, two tools, two gaskets, and packaging that also serves as one or more water containers. In some embodiments, the two gaskets are two conventional gaskets that can be combined to make a third gasket. In some embodiments, the combination of the two gaskets allows the creation of a synergistic gasket for sealing a tank-to-bowl interface than neither gasket could seal individually.

Abstract: An aircraft capable of carrying at least 400 pounds of payload, has four rotors systems, each of the rotor systems being independently driven by an electric motor or other torque-producing source. Each of the rotor systems provide sufficient thrust such that the aircraft is capable of controlled vertical takeoff and landing, even if one of the variable pitch rotor is inoperable. An electronic control system is configured to control the rotational speed and pitch of at least one of the rotor systems in each of the first and second rotor pairs. The rotors may be arranged in coaxial stacks or maybe otherwise configured.

Abstract: Certain embodiments relate to optical devices and methods of fabricating optical devices that pre-treat a sub-layer to enable selective removal of the pre-treated sub-layer and overlying layers. Other embodiments pertain to methods of fabricating an optical device that apply a sacrificial material layer.

Abstract: Methods of determining a polygon ablation pattern for use in mitigating one or more defects in an optical device are described. A method comprises identifying spatial coordinates of one or more defects areas in a first image of the optical device taken when tinted, defining a region of interest around at least one defect area of the one or more defect areas, and determining a polygon boundary around the at least one defect area in the region of interest to define the polygon ablation pattern.

Abstract: A system and method for enhancing C*RAM, improving its performance for known applications such as video processing but also making it well suited to low-power implementation of neural nets. The required computing engine is decomposed into banks of enhanced C*RAM each having a SIMD controller, thus allowing operations at several scales simultaneously. Several configurations of suitable controllers are discussed, along with communication structures and enhanced processing elements.

Abstract: Dipole audio speakers, and more particularly, voice controlled dipole audio speakers having at least one microphone located substantially along the null sound plane of the dipole audio speaker. An improved loudspeaker system that produces an improved audio quality for stereophonic sound. The improved loudspeaker utilizes conventional electro-dynamic drivers in a sealed chamber that produce sound primarily in the 20-300 Hz band coupled with electrostatic card stack drivers placed outside the sealed chamber that cover the remaining 98% of the audio frequency spectrum (300 Hz to 20 kHz). The improved loudspeaker system can also include multiple card stack drivers that are placed at angles with respect to each other to maximize audio fidelity.

Abstract: A pump panel training device is provided and includes a plurality of simulated gages operable to imitate gages upon a fire truck pump panel, a plurality of simulated controls operable to imitate controls upon the fire truck pump panel, and a simulated water hose operable to imitate one of water temperature changes, water temperature pressure, and water hose vibration for the fire truck pump panel.

Abstract: A method may include creating an association identifier based on an association between a computational device function and a compute engine of a computational device, and invoking an execute command to perform an execution of the computational device function using the compute engine, wherein the execute command uses the association identifier. The compute engine may be a first compute engine, and the association may be further between the computational device function and a second compute engine of the computational device. The execute command may perform an execution of the computational device function using the second compute engine. The execution of the computational device function using the first compute engine and the execution of the computational device function using the second compute engine may overlap. The execute command may include the association identifier. The creating the association identifier may include invoking a create association command.

Abstract: Systems, methods, and non-transitory computer-readable storage media for intelligently managing a playlist of digital media provide an intelligent dynamic queue that is configured to manage the playback of digital media. The queue can transition between passive playback mode, active playback mode, and mixed playback mode. The queue can handle the playback of the songs in the queue according to the playback mode and/or a queue status field that is associated with each song in the queue.

Abstract: Provided are systems, methods, and apparatuses for managing storage device memory. A method can include receiving, from a host, a command for managing the memory; performing, by the storage device, the command on first data stored on the memory via at least one processing element in the storage device to generate second data; and transmitting, by the storage device, third data based on the second data to the host.