Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract: A compound having formula (I) wherein R1, R2, R3, R4, R5 and R6 are defined in the description, is disclosed as an P2X7 antagonist. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Abstract: A mobile collection application is disclosed that is capable of providing collection data to a field agent on a wireless pocket PC. A collection case inventory module is used to generate a list of collection cases on the wireless pocket PC. The field agent may view a detailed report of collection cases that are contained in the list of collection cases. A payment plan component is also provided that allows the field agent to work out a payment plan with the debtor. The mobile collection application is also capable of allowing field agents to register transient taxpayers for the purpose of collecting sales and use taxes.

Abstract: The present invention provides methods to treat mood disorders and anxiety disorders using antagonists of the P2X7 receptor and pharmaceutical compositions thereof, or combinations.

Abstract: Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

Abstract: Apparatus and methods for non-invasive electrical stimulation of the brain through skin surface stimulation of the peripheral nervous system as a treatment for movement disorders. Skin surface electrodes are positioned at predetermined peripheral surface stimulation sites on the skin surface using a variety of neural imaging techniques. A pulsatile electrical current is generated at the stimulation sites through a variety of standard electrical stimulation devices. Stimulation of the peripheral surface stimulation sites translates to electrical stimulation of a specific area of the brain.

Abstract: A repair swatch (such as a patch) is provided that is preferably covered with appropriate granules on one face, with an opposite (back) face having an adhesive that allows the material to be placed over and adhere to small damaged areas of shingles and/or other types of roofing. The size, shape and color of the patch are such that it closely matches that of the existing shingle. Further, the size and shape of the patch are similar to shapes on laminated shingle products rendering the repair essentially invisible on such products.

Abstract: Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

Abstract: The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 are defined in the specification. The invention is also directed to a method of selectively inhibiting P2X7 activity comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (III), (IV) or (V) wherein R6, R7, R8, R9, R10, and R11 are defined in the specification.

Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Abstract: The present invention is an apparatus having a stabilizing device, at least two signal applicators, and a signal generator for surface electrical stimulation and stabilization to treat disorders of the joints.

Abstract: The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.

Abstract: The present invention discloses a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein D, A, m, n, Rx and Ry are defined in the description. The present invention also relates to pharmaceutical compositions of compounds of formula (I), which are useful for treating a disorder selected from the group consisting of chronic inflammatory pain, neuropathic pain, inflammation, neurodegeneration, depression and promoting neuroregeneration. The present invention also relates to a method for treating pain, neuropathic pain, inflammation, chronic inflammatory pain, neurodegeneration, depression and promoting neuroregeneration in a mammal using compounds of formula (II), a pharmaceutically acceptable salt, ester, amide or prodrug thereof, wherein R3 and R4 are defined in the description.

Abstract: A digital video cassette recorder which is adapted for use on an aircraft to record video data in a digital format as opposed to an analog format. The recorder includes a frame sync card for adding color burst to video which is black and white and a GPS to SMPTE converter which passes the video signal through converter to the video cassette recorder and also uses the video signal to encode Time, Space, and Position Information data onto a SMPTE time code for each frame of video data supplied to the recorder.

Abstract: The present invention relates to the use of selective P2X7 receptor antagonists of formula I, or a pharmaceutically acceptable salt or prodrug thereof wherein D, R1 and R2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration,

Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Abstract: An electrode configuration for surface electrical stimulation to treat chronic and acute pain electrically re-routes current through one of a variety of possible switching means to selectively use a set of electrodes in different modes, for example, in a cross current mode or a longitudinal current mode.

Abstract: Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

Abstract: The present invention provides a mold composition having improved impact resistance and low shrinkage. The molding composition comprises a urethane chain extended polyester formed by reacting in situ a low molecular weight unsaturated polyester polyol resin and a polyisocyanate intermediate free from ethylenic unsaturation, and a low profile additive.

Abstract: The Reversible Doorjamb Square is an improved tool designed as a solid one piece 90-degree right angle square that slides into a plastic lined box beam jamb tube. The invention will allow the user to temporally secure a doorjamb in place before permanently nailing it to the framing members. Adjustments are possible by means of cam levers, calibration screws and stand-off discs that allow the user to position the unit plumb, level, square and flush to the finish wall.