Abstract: The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.

Abstract: A mobile collection application is disclosed that is capable of providing collection data to a field agent on a wireless pocket PC. A collection case inventory module is used to generate a list of collection cases on the wireless pocket PC. The field agent may view a detailed report of collection cases that are contained in the list of collection cases. A payment plan component is also provided that allows the field agent to work out a payment plan with the debtor. The mobile collection application is also capable of allowing field agents to register transient taxpayers for the purpose of collecting sales and use taxes.

Abstract: Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described.

Abstract: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.

Abstract: The present application describes a method of treating conditions treatable with a CB2 cannabinoid receptor agonist with reduced CB1-mediated side effects using a combination therapy comprising a CB2 agonist and a CB1 ligand, which can be a CB1 antagonist or a CB1 inverse agonist.

Abstract: The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Abstract: An apparatus for providing stabilization during a tracking operation may include a processing element configured to define an inertial pointing vector relative to a point of interest, receive tracking information related to the point of interest, and determine compensation of the inertial pointing vector based on the received tracking information and motion of a platform conducting the tracking operation.

Abstract: A method of treating or preventing disease, said method comprising administering to a subject, simultaneously, sequentially or separately, an antigen and a chemotherapeutic agent or agents comprising the steps of: administering the chemotherapeutic agent or agents, and administering an antigen up to 6 weeks after the chemotherapeutic agent.

Abstract: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract: The present application relates to cannabinoid receptor ligands containing compounds of formula (I) wherein A, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.

Abstract: The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, and R4 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract: The present invention relates to compounds of formula (I) wherein A, E, L2, R1, R3, R4 and R5 are as defined in the herein, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract: A portable anti-theft brake pedal locking device for a motor vehicle, comprising a horizontal barrier member, upwardly extending, u-shaped rod shackle engaging members, and a manner of locking the device against removal from beneath existing brake/clutch pedal(s). The manner of locking may be either by a lock integral to the anti-theft device, in the form of a pivoting catching lock member, or by a lock independent of the anti-theft device, such as by a padlock. This portable anti-theft device in its preferred embodiment may be double-locked through use of the lock integral to the anti-theft device, and also secondarily by use of the independent locking padlock. Through the placement of this device beneath the under edge of a brake pedal shaft, the under edge of a clutch pedal shaft when present, against the vehicle floorboard, and locking the device to the brake pedal shaft, a resulting disabling of the operation of such pedals is accomplished by preventing the pedals being depressed.

Abstract: The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Abstract: The present invention relates to thiazolidinylidene containing compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, and X are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract: A tappet for an internal combustion engine is formed from a high-carbon, bearing grade steel. The high-carbon, bearing grade steel has a relatively high surface fatigue strength that provides the tappet with the ability to absorb a relatively large contact stresses during operation, thereby minimizing the formation of cracks within the tappet. Additionally, the high-carbon steel tappet can be heat treated to provide a substantially uniform hardness, between about 58 Rockwell Hardness C (HRC) and 62 HRC, and a substantially consistent microstructure throughout the tappet, thereby minimizing wear of the tappet during use.

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.