Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

Abstract: An integrated bearing section includes a mandrel partially disposed within a housing. The bearing section includes spherical members disposed between the mandrel's outer surface and the housing's inner surface. A radial bearing portion is formed by spherical members disposed partially within grooves and engaging a flat profile opposing surface. The grooves may be in the mandrel's outer surface, an outer surface of a mandrel sleeve, the housing's inner surface, or an outer radial bearing's inner surface. The flat profile opposing surface may be on an outer radial bearing's inner surface, the housing's inner surface, the mandrel's outer surface, or a mandrel sleeve's outer surface. A thrust bearing portion is formed by spherical members disposed partially within grooves in two opposing surfaces, such as the mandrel's outer surface or a mandrel sleeve's outer surface, and the housing's inner surface or an outer thrust bearing's inner surface.

Abstract: A mud-lubricated bearing section including a seal assembly for directing a fluid flowing through a mud-lubricated bearing into a central bore of a mandrel. At least one mud-lubricated bearing is positioned in an annular space between the mandrel and a housing. The seal assembly directs the fluid from the annular space through a mandrel fluid port into the mandrel central bore. The seal assembly seals the annular space, and includes a piston, a plug, and a chamber between the piston and the plug. The piston is configured for axial movement relative to the mandrel and the housing, while the plug is axially fixed relative to the mandrel and/or the housing. The chamber is configured to contain a lubricating fluid. The piston includes inner and outer seals. The plug includes a lower seal and a passage allowing the fluid from the chamber to reach the lower seal for lubrication.

Abstract: A vibration assembly includes a valve above a rotor and stator. The rotor rotates within the stator as fluid flows therethrough. The valve includes a rotating valve segment, which rotates with the rotor, and a non-rotating valve segment each including at least one fluid passage. In an open position, the fluid passages of the valve segments are aligned and a fluid flows through the valve. In a restricted position, the fluid passages of the valve segments are partially or completely unaligned, thereby creating a pressure pulse that is transmitted through the drill string or coiled tubing above the valve. The valve may further include an inner sleeve and an outer sleeve surrounding the non-rotating valve segment. The inner and outer sleeves allow axial sliding but prevent rotation of the non-rotating valve segment. The assembly may further include a lower thrust bearing at a lower end of the rotor.

Abstract: In non-limiting examples of the present disclosure, systems, methods and devices for collecting and surfacing web content are provided. Web content from a webpage may be displayed in a web browser. A type associated with the webpage may be identified. An indication to add a new section corresponding to the webpage to a content collection pane may be received. A plurality of elements on the webpage may be identified based on the identified type associated with the webpage. A subset of web content from the webpage corresponding to the plurality of elements may be extracted. The new section may be added to the content collection pane, wherein the new section comprises the subset of web content extracted from the webpage.

Abstract: A vibration assembly includes a valve above a rotor and stator. The rotor rotates within the stator as fluid flows therethrough. The valve includes a rotating valve segment, which rotates with the rotor, and a non-rotating valve segment each including at least one fluid passage. In an open position, the fluid passages of the valve segments are aligned and a fluid flows through the valve. In a restricted position, the fluid passages of the valve segments are partially or completely unaligned, thereby creating a pressure pulse that is transmitted through the drill string or coiled tubing above the valve. The valve may further include an inner sleeve and an outer sleeve surrounding the non-rotating valve segment. The inner and outer sleeves allow axial sliding but prevent rotation of the non-rotating valve segment. The assembly may further include a lower thrust bearing at a lower end of the rotor.

Abstract: Technology for using a nested probabilistic data structure to determine properties of a data set. An example method may involve: receiving a data item comprising a first and second item values; accessing a first probabilistic data structure comprising elements with references to a plurality of second probabilistic data structures; evaluating the first probabilistic data structure to identify a set of the second probabilistic data structures, wherein the evaluating comprises applying a set of hash functions to the first item value to generate hash values indicating the set of second probabilistic data structures corresponding to the first item value; evaluating one of the second probabilistic data structures in view of the second item value to identify a set of elements of the second probabilistic data structure corresponding to the second item value; and updating the set of elements of the second probabilistic data structure to represent the data item.

Abstract: A drilling assembly includes a power section with a housing that rotates in a first direction at a drill string rotation rate. An output rotates a drill bit through a transmission shaft in the first direction at a rotor rotation rate relative to the housing. A bent housing between the power section and the drill bit rotates in a second direction at a variable rotation rate relative to the power housing. The transmission shaft extends through the bent housing. A mechanical brake system adjusts the bent housing's variable rotation rate. The bent housing rotates relative to the wellbore in a rotary mode, but not in a sliding mode. The sliding mode maintains the drill bit's direction and inclination while the drill string rotates. In all modes, the drill bit's rotation rate is the sum of the drill string rate and the rotor rate relative to the power housing.

Abstract: A downhole vibration assembly includes a valve positioned above a rotor that is disposed at least partially within a stator. The rotor is operatively suspended within an inner bore of a housing and configured to rotate within the stator as a fluid flows through the vibration assembly. The valve includes a rotating valve segment and a stationary valve segment each including at least one fluid passage. The rotating valve segment rotates with a rotation of the rotor. In an open position, the fluid passages of the valve segments are aligned and a fluid flows through the valve. In a restricted position, the fluid passages of the valve segments are partially or completely unaligned, thereby temporarily restricting the fluid flow through the valve to create a pressure pulse. The unobstructed pressure pulse is transmitted through the drill string or coiled tubing above the valve.

Abstract: A water filtration device includes a diffusiophoretic water filter having an inlet and an outlet and for receiving a colloidal suspension at the inlet and flowing the colloidal suspension between the inlet and the outlet in a flow direction; a diffusiophoretic-inducing membrane; a cover, the membrane and the cover defining a plurality of channels extending between the inlet and the outlet; an outlet splitter for the plurality of channels being fixed with respect to the membrane or the cover, the cover and membrane being flexible and configured to permit rolling up of the membrane and the cover. A related method is also provided.

Abstract: A mud-lubricated bearing section including a seal assembly for directing a fluid flowing through a mud-lubricated bearing into a central bore of a mandrel. At least one mud-lubricated bearing is positioned in an annular space between the mandrel and a housing. The seal assembly directs the fluid from the annular space through a mandrel fluid port into the mandrel central bore. The seal assembly seals the annular space, and includes a piston, a plug, and a chamber between the piston and the plug. The piston is configured for axial movement relative to the mandrel and the housing, while the plug is axially fixed relative to the mandrel and/or the housing. The chamber is configured to contain a lubricating fluid. The piston includes inner and outer seals. The plug includes a lower seal and a passage allowing the fluid from the chamber to reach the lower seal for lubrication.

Abstract: Disclosed are various approaches for retrieving contacts from a plurality of federated services. A query is received from a client application executing on a client device, the query comprising a single sign-on token that identifies a user and a character string. A number of federated services that the user has permission to access are then identified. A plurality of authentication tokens are then retrieved from an authentication service, each of the plurality of authentication tokens identifying the user to a respective one of the plurality of federated services. Next, the authentication token and the character string are provided to a respective connector for each of the plurality of federated services that the user has permission to access. A plurality of responses are received, each of the plurality of responses being received from the respective connector corresponding to each of the plurality of federated services that the user has permission to access.

Abstract: Repeatable distributed pseudorandom number generation is disclosed. For example, a system has a plurality of pseudorandom number generators (“PRNGs”) including a first and second PRNGs and a randomization engine including a seed engine configured to control the plurality of PRNGs by executing to generate a plurality of seed values equal in quantity to the plurality of PRNGs, including first and second seed values. The first seed value is assigned to the first PRNG and the second seed value to the second PRNG. A first pseudorandom number (“PRN”) set is received from the first PRNG and a second PRN set from the second PRNG. A plurality of PRN sets from the plurality of PRNGs is combined into a combined number set.

Abstract: A diffusiophoretic water filtration device includes a diffusiophoretic flow chamber having an inlet and an outlet, the flow chamber for receiving the colloidal suspension at the inlet from the inlet manifold, and passing the colloidal suspension between the inlet and at least one outlet in a flow direction; the flow chamber having a removable and reassemblable cover defining a boundary of the diffusiophoretic flow chamber.

Abstract: An integrated bearing section includes a mandrel partially disposed within a housing. The bearing section includes spherical members disposed between the mandrel's outer surface and the housing's inner surface. A radial bearing portion is formed by spherical members disposed partially within grooves and engaging a flat profile opposing surface. The grooves may be in the mandrel's outer surface, an outer surface of a mandrel sleeve, the housing's inner surface, or an outer radial bearing's inner surface. The flat profile opposing surface may be on an outer radial bearing's inner surface, the housing's inner surface, the mandrel's outer surface, or a mandrel sleeve's outer surface. A thrust bearing portion is formed by spherical members disposed partially within grooves in two opposing surfaces, such as the mandrel's outer surface or a mandrel sleeve's outer surface, and the housing's inner surface or an outer thrust bearing's inner surface.

Abstract: A method for automated reconfiguration of a commodity distribution system is provided. The method includes operating a plurality of nodes located in the distribution system and a plurality of node controllers. The node controllers control respective nodes in accordance with a first or second operating mode to affect system reconfiguration in response to a fault condition, loading, system optimization, system expansion and combinations thereof.

Abstract: An easily assemblable water filtration device includes an inlet manifold for receiving a colloidal suspension including colloidal particles in water; and a diffusiophoretic water filter having at least one channel having an inlet and an outlet and for receiving the colloidal suspension at the inlet from the inlet manifold and flowing the colloidal suspension between the inlet and the outlet in a flow direction, the diffusiophoretic water filter having a pressurizable gas chamber for providing pressurized gas to the at least one channel via a gas permeable and water impermeable membrane. An outlet splitter connects to or is at the outlet, the outlet splitter having a first splitter outlet and a second splitter outlet, the first splitter outlet for receiving water having a higher concentration of some of the colloidal particles than a second splitter outlet. The outlet splitter, the membrane and at least parts of the inlet can be removable.

Abstract: A diffusiophoretic water filtration device has a pressurizable gas chamber for receiving a pressurized gas; an inlet manifold for receiving a colloidal suspension including colloidal particles in water; a flow chamber having an inlet and an outlet, the flow chamber for receiving the colloidal suspension at the inlet from the inlet manifold, the colloidal suspension flowing between the inlet and at least one outlet in a flow direction; and a gas membrane separating the gas chamber and the flow chamber, the sheet being made of a gas permeable membrane, the pressurized gas capable of permeating the membrane, the membrane being water impermeable, the gas membrane having a first side facing the pressurized gas chamber, and a second side facing the flow chamber, the flow chamber having a plurality of channels, each channel contacting the second side of the membrane; and an outlet splitter separating a first outlet from a second outlet and splitting the plurality of channels, the first outlet for receiving water hav

Abstract: A downhole vibration assembly includes a valve positioned above a rotor that is disposed at least partially within a stator. The rotor is operatively suspended within an inner bore of a housing and configured to rotate within the stator as a fluid flows through the vibration assembly. The valve includes a rotating valve segment and a stationary valve segment each including at least one fluid passage. The rotating valve segment rotates with a rotation of the rotor. In an open position, the fluid passages of the valve segments are aligned and a fluid flows through the valve. In a restricted position, the fluid passages of the valve segments are partially or completely unaligned, thereby temporarily restricting the fluid flow through the valve to create a pressure pulse. The unobstructed pressure pulse is transmitted through the drill string or coiled tubing above the valve.

Abstract: A water filtration device is provided including a pressurized gas chamber receiving a pressurized gas; an open flow chamber receiving a colloidal suspension including water and colloidal particles, the open flow chamber having an inlet and an outlet, the colloidal suspension flowing between the inlet and at least one outlet in a flow direction; and a gas permeable membrane separating the gas chamber and the flow chamber, the gas capable of permeating the membrane, the membrane being water impermeable, the gas permeating the membrane in a direction normal to the membrane so as to induce diffusiophoretic motion on at least some of the colloidal particles opposite to or in a direction normal to the membrane; the at least one outlet having a first outlet with water having a higher concentration of the colloidal particles than a second outlet. Other devices and methods are also provided.