Abstract: The present invention relates to CD27L antigen binding proteins, such an antibodies, polynucleotides encoding said CD27l antigen binding proteins, antibody drug conjugate compositions, and methods for diagnosing and treating diseases associated with CD27L expression.

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

Abstract: A method and system that includes extracting event models from at least one personal planning source of a user, wherein a parameter of an event model includes event location; periodically receiving location information of at least one mobile device of the user; storing the location information in a location log; a pattern worker module maintaining user location patterns through the location log; generating a location prediction from the extracted event models and the user location patterns; a first content worker module checking if the location prediction meets a set of content requirements; if the set of content requirements is satisfied, initiating content retrieval from at least one service; and pushing the content to the mobile device.

Abstract: The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce salvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implantated in the body.

Abstract: An apparatus categorizes knowledge elements that an investigator derives from source materials into issue categories. The issue categories may be predefined based on the type or nature of the investigative matter or user-defined as circumstances dictate. The apparatus also allows for preparation of a narrative based on the knowledge elements and source materials. A hopper allows a user to view and access the categorized knowledge elements during preparation of the narrative. Accordingly, through this collaboration process, investigators may produce a narrative more accurately and efficiently. Further, the apparatus links the text in the narrative back to the knowledge elements and the source materials which may be easily accessed via the links to enable them to be reviewed to determine whether the relevant text in the narrative is firmly based thereon. Thus, review of the work product created with the apparatus may be simplified.

Abstract: The present invention relates to CD27L antigen binding proteins, such an antibodies, polynucleotides encoding said CD27l antigen binding proteins, antibody drug conjugate compositions, and methods for diagnosing and treating diseases associated with CD27L expression.

Abstract: The system and method utilize the inter-relationship of items in a psychological instrument or instruments and have been demonstrated empirically to detect problematic conceptualizations of constructs. Scores from the instruments are submitted for review. The scores are analyzed by a computer program that compares item level scores with expected values based on the item inter-relationships. If inconsistencies are discovered a flag is generated. If inconsistencies are deemed actionable then remedial action or contact is scheduled with the site-based clinician or “rater” who conducted the patient assessment using the instrument or instruments. The site-based clinician is contacted and an information exchange about the case occurs in which the site-based clinician provides an overview of symptom presentation. This symptom presentation is then matched to the item level scores on the instrument to determine if it was scored in a manner consistent with the conceptual basis for the items.

Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.

Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.

Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.

Abstract: A methodology and related system apparatus is provided to most efficiently and flexibly respond to abnormalities to reconfigure and restore service to end customers in commodity distribution systems to enhance the circuit reconfiguration in an electrical power distribution system. Methodology is also provided to appropriately allocate system resources of the distribution system to prevent the potential overloading of electrical power sources. In one illustrative arrangement, the methodology is characterized by resources at each node and communications of source allocation data or messages to other nodes to request and establish an appropriate allocation of system resources.

Abstract: An apparatus for controlling the direction of drill bit within a wellbore. The apparatus comprises a first housing with a first housing axis therein, and wherein the first housing has a first threaded opening having a first threaded opening axis. The first housing has a helical end. A second housing is included, and the second housing contains a second housing axis, and a second threaded opening having a second threaded opening axis configured to engage with the first threaded opening. A collar is included that has a helical collar end that engages the helical collar end and wherein the helical collar end is configured reciprocal to the helical end, and rotational displacement of the first housing relative to the collar will angularly displace the drill bit axis. The apparatus may further include spline members for locking the collar in place relative to the first and second housing.

Abstract: Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

Abstract: A methodology and related system apparatus is provided to most efficiently and flexibly respond to abnormalities to reconfigure and restore service to end customers in commodity distribution systems to enhance circuit reconfiguration in an electrical power distribution system. Methodology is also provided to appropriately allocate system resources of the distribution system to prevent the potential overloading of electrical power sources. In one illustrative arrangement, the methodology is characterized by resources at each node and communications of source allocation data or messages to other nodes to request and establish an appropriate allocation of system resources.

Abstract: The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides.

Abstract: The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides.

Abstract: The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides.

Abstract: Many proteins, when produced recombinantly, suffer from improper processing, folding and lack normal solubility. Modified proteins, including those indicative of disease states, also can have such defects. The present invention is directed to methods of identifying proper and improper protein folding, aberrant processing and/or insolubility. The method relies on the use of two components: a specialized fusion protein and structural complementation. The fusion protein contains sequences from the protein of interest and one portion of a marker protein that, by itself, is not active. A host cell then provides the remainder of the marker protein that serves to “complement” the function of the fused marker protein such that their association restores activity, permitting detection.

Abstract: The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce salvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implantated in the body.

Abstract: An apparatus for controlling the direction of drill bit within a wellbore. The apparatus comprises a first housing with a first housing axis therein, and wherein the first housing has a first threaded opening having a first threaded opening axis. The first housing has a helical end. A second housing is included, and the second housing contains a second housing axis, and a second threaded opening having a second threaded opening axis configured to engage with the first threaded opening. A collar is included that has a helical collar end that engages the helical collar end and wherein the helical collar end is configured reciprocal to the helical end, and rotational displacement of the first housing relative to the collar will angularly displace the drill bit axis. The apparatus may further include spline members for locking the collar in place relative to the first and second housing.