Abstract: This disclosure generally relates to pyridine-2-one compounds of formula (I) and methods of using them in the treatment of a disorder, such as cancer or a SMARCA2-associated disorder, including as antagonists (e.g., inhibitors) of SMARCA2. The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, compounds, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancers. Some aspects of this disclosure provide treatment modalities, methods, strategies, compounds, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: The present disclosure relates to substituted fused bi- or tri-heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering a substituted fused bi- or tri-heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: In non-limiting examples of the present disclosure, systems, methods and devices for integrating speech-to-text transcription in a productivity application are presented. A request to access a real-time speech-to-text transcription of an audio signal that is being received by a second device is sent by a first device. The real-time speech-to-text transcription may be surfaced in a transcription pane of a productivity application on the first device. A request to translate the transcription to a different language may be received. The transcription may be translated in real-time and surfaced in the transcription pane. A selection of a word in the surfaced transcription may be received. A request to drag the word from the transcription pane and drop it in a window in the productivity application outside of the transcription pane may be received. The word may be surfaced in the window in the productivity application outside of the transcription pane.

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: This disclosure presents a MITLIF procedure. The procedure uses a single incision on one side and pedicle screws are placed on that side and through the same incision a facet screw is placed on the opposite side using a series of jigs, and, for example, the hole cutter, drill, guide shaft and screw driver described herein.

Abstract: Concepts, systems and methods are described for generating a quantum circuit from a Unitary Coupled Cluster (UCC) ansatz which represents the excitation of a reference state by a parameterised operator including excitation operators. The UCC ansatz includes multi-qubit Pauli operators, referred to as Pauli strings, determined from each excitation operator. The method comprises partitioning the Pauli strings into mutually commuting sets and sequencing the Pauli strings by set. Pauli gadgets are then generated from the Pauli strings by Trotterization, the Pauli gadgets having the same sequencing by set as the Pauli strings. Each set of Pauli gadgets is diagonalised to convert the Pauli gadgets into phase gadgets which are then transformed into one- and two-qubit native gates to generate the quantum circuit.

Abstract: Concepts, systems and methods are described for generating a quantum circuit from a Unitary Coupled Cluster (UCC) ansatz which represents the excitation of a reference state by a parameterised operator including excitation operators. The UCC ansatz includes multi-qubit Pauli operators, referred to as Pauli strings, determined from each excitation operator. The method comprises partitioning the Pauli strings into mutually commuting sets and sequencing the Pauli strings by set. Pauli gadgets are then generated from the Pauli strings by Trotterization, the Pauli gadgets having the same sequencing by set as the Pauli strings. Each set of Pauli gadgets is diagonalised to convert the Pauli gadgets into phase gadgets which are then transformed into one- and two-qubit native gates to generate the quantum circuit.

Abstract: This disclosure presents a MITLIF procedure. The procedure uses a single incision on one side and pedicle screws are placed on that side and through the same incision a facet screw is placed on the opposite side using a series of jigs, and, for example, the hole cutter, drill, guide shaft and screw driver described herein.

Abstract: The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: In non-limiting examples of the present disclosure, systems, methods and devices for integrating speech-to-text transcription in a productivity application are presented. A request to access a real-time speech-to-text transcription of an audio signal that is being received by a second device is sent by a first device. The real-time speech-to-text transcription may be surfaced in a transcription pane of a productivity application on the first device. A request to translate the transcription to a different language may be received. The transcription may be translated in real-time and surfaced in the transcription pane. A selection of a word in the surfaced transcription may be received. A request to drag the word from the transcription pane and drop it in a window in the productivity application outside of the transcription pane may be received. The word may be surfaced in the window in the productivity application outside of the transcription pane.

Abstract: In some examples, an electronic device may determine a target time to which the remaining battery charge is to last, such as based on a user input or historical usage of the electronic device. Additionally, the electronic device may determine a current amount of the battery charge remaining, and may determine user activities likely to occur between the present time and the target time. Based at least partially on the amount of the battery charge remaining and the user activities determined to be likely to occur before the target time, the electronic device may apply one or more power management restrictions to one or more resources of the electronic device.

Abstract: Methods, systems, computer program products and data structures are described which allow for efficient correction of a transcription output of an automatic speech recognition system by a human proofreader. A method comprises receiving a voice input from a user; determining a transcription of the voice input; providing the transcription of the voice input; receiving a text input from the user indicating a revision to the transcription; determining how to revise the transcription in accordance with the text input; and revising the transcription of the voice input in accordance with the text input. A general or specialized language model, an acoustical language model, a character language model, a gaze tracker, and/or a stylus may be used to determine how to revise the transcription in accordance with the text input.

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds and derivatives thereof. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: Devices, assemblies, kits and methods for an accessory for a recreational vehicle are shown and described. An accessory may include a tray, an extension and a cover for the tray. The tray may be a horizontally oriented tray supported by the support and having a set of compartments and a set of recesses. The tray may be mountable between variable positions.