Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.

Abstract: Provided herein are energy storage devices. In some cases, the energy storage devices are capable of being transported on a vehicle and storing a large amount of energy. An energy storage device is provided comprising at least one liquid metal electrode, an energy storage capacity of at least about 1 MWh and a response time less than or equal to about 100 milliseconds (ms).

Abstract: The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction,

Abstract: The present invention relates to Nav1.8 Inhibitor 2,3-dihydroquinazolin compounds of Formula (X): wherein Y?, X?, B?, R1?, R2?, R3?, R5?, R6?, R7?, and z1 are as defined herein; or pharmaceutically acceptable salts or tautomer forms thereof, corresponding pharmaceutical compositions or formulations, methods or processes of compound preparation, methods, compounds for use in, uses for and/or combination therapies for treating pain and/or pain-related or associated disease(s), disorder(s) or condition(s), respectively.

Abstract: The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A system and method of creating frames comprised of blocks, where each block comprises data symbols corresponding to a higher order quadrature modulation format and support symbols corresponding to a lower order modulation format. One or more of the blocks can further comprise markers comprising distinct symbol patterns. The markers can mark the start of each frame and/or another location in the frame. The support symbols can be in a common location in each block.

Abstract: A system and method of creating frames comprised of blocks, where each block comprises data symbols corresponding to a higher order quadrature modulation format and support symbols corresponding to a lower order modulation format. One or more of the blocks can further comprise markers comprising distinct symbol patterns. The markers can mark the start of each frame and/or another location in the frame. The support symbols can be in a common location in each block.

Abstract: A system and method of creating frames comprised of blocks, where each block comprises data symbols corresponding to a higher order quadrature modulation format and support symbols corresponding to a lower order modulation format. One or more of the blocks can further comprise markers comprising distinct symbol patterns. The markers can mark the start of each frame and/or another location in the frame. The support symbols can be in a common location in each block.

Abstract: A system and method of creating frames comprised of blocks, where each block comprises data symbols corresponding to a higher order quadrature modulation format and support symbols corresponding to a lower order modulation format. One or more of the blocks can further comprise markers comprising distinct symbol patterns. The markers can mark the start of each frame and/or another location in the frame. The support symbols can be in a common location in each block.

Abstract: A system and method of creating frames comprised of blocks, where each block comprises data symbols corresponding to a higher order quadrature modulation format and support symbols corresponding to a lower order modulation format. One or more of the blocks can further comprise markers comprising distinct symbol patterns. The markers can mark the start of each frame and/or another location in the frame. The support symbols can be in a common location in each block.

Abstract: Provided herein are processes for the preparation of 2-thiophenecarbonyl chloride, which is useful, for example, in the preparation of 3,5-disubstituted-1,2,4-oxadiazoles, such as tioxazafen (3-phenyl-5-(2-thienyl)-1,2,4-oxadiazole).

Abstract: Provided herein are processes for the preparation of 2-thiophenecarbonyl chloride, which is useful, for example, in the preparation of 3,5-disubstituted-1,2,4-oxadiazoles, such as tioxazafen (3-phenyl-5-(2-thienyl)-1,2,4-oxadiazole).

Abstract: A first device transmits a first Fiber Channel frame with a first priority to a second device. The first device receives a second Fiber Channel frame from the second device, where the second Fiber Channel frame has a second priority indicated by the second device. The first device determines whether to adopt the second priority indicated by the second device or whether to continue to use the first priority for transmitting subsequent Fiber Channel frames to the second device.

Abstract: A neutron detection apparatus includes a neutron detector and an analyzer. The neutron detector includes a plurality of neutron detector assemblies, where each of the neutron detector assemblies includes a plurality of neutron detection devices. The neutron detector also includes a moderating volume. The plurality of neutron detector assemblies are disposed within the moderating volume so as to form a three-dimensional array of neutron detection devices within the moderating volume. The analyzer is communicatively coupled to each of the neutron detection devices of the plurality of neutron detector assemblies. The analyzer configured to receive one or more measured response signals from each of the neutron detection devices, and perform one or more analysis procedures to determine one or more characteristics associated with the one or more neutron sources based at least on the received one or more measured response signals.

Abstract: A first device transmits a first Fibre Channel frame with a first priority to a second device. The first device receives a second Fibre Channel frame from the second device, where the second Fibre Channel frame has a second priority indicated by the second device. The first device determines whether to adopt the second priority indicated by the second device or whether to continue to use the first priority for transmitting subsequent Fibre Channel frames to the second device.

Abstract: A neutron detection apparatus includes a neutron detector and an analyzer. The neutron detector includes a plurality of neutron detector assemblies, where each of the neutron detector assemblies includes a plurality of neutron detection devices. The neutron detector also includes a moderating volume. The plurality of neutron detector assemblies are disposed within the moderating volume so as to form a three-dimensional array of neutron detection devices within the moderating volume. The analyzer is communicatively coupled to each of the neutron detection devices of the plurality of neutron detector assemblies. The analyzer configured to receive one or more measured response signals from each of the neutron detection devices, and perform one or more analysis procedures to determine one or more characteristics associated with the one or more neutron sources based at least on the received one or more measured response signals.

Abstract: A neutron detection system may include a neutron detector including a plurality of neutron detection devices, a plurality of discrete neutron moderating elements, wherein each of the neutron moderating elements is disposed between two or more neutron detection devices, the plurality of neutron detection devices and the plurality of discrete neutron moderating elements disposed along a common axis, a control system configured to generate a detector response library, wherein the detector response library includes one or more sets of data indicative of a response of the detector to a known neutron source, receive one or more measured neutron response signals from each of the neutron devices, the one or more measured response signals response to a detected neutron event, and determine one or more characteristics of neutrons emanating from a measured neutron source by comparing the one or more measured neutron response signals to the detector response library.

Abstract: A neutron detection system includes a plurality of neutron detector assemblies, the neutron detector assemblies including a plurality of neutron detection devices, wherein the neutron detection devices are configured to detect one or more characteristics of neutrons emanating from one or more neutron sources and impinging on one or more neutron detection devices; a plurality of discrete moderating elements, wherein each of the discrete moderating elements is disposed proximate to at least one neutron detector assembly, the plurality of neutron detector assemblies and the plurality of discrete moderating elements disposed along a common axis, wherein the discrete moderating elements are configured to moderate the energy of neutrons impinging on one or more of the neutron-photon detector assemblies; and a control system configured to: determine one or more characteristics associated with the one or more neutron sources based on the received one or more measured response signals.

Abstract: A neutron detection system may include a neutron detector including a plurality of neutron detection devices, a plurality of discrete neutron moderating elements, wherein each of the neutron moderating elements is disposed between two or more neutron detection devices, the plurality of neutron detection devices and the plurality of discrete neutron moderating elements disposed along a common axis, a control system configured to generate a detector response library, wherein the detector response library includes one or more sets of data indicative of a response of the detector to a known neutron source, receive one or more measured neutron response signals from each of the neutron devices, the one or more measured response signals response to a detected neutron event, and determine one or more characteristics of neutrons emanating from a measured neutron source by comparing the one or more measured neutron response signals to the detector response library.

Abstract: A delivery system in the form of a soluble fiber formulation for therapeutic supplement and medication delivery includes approximately 70%-80% water, 14%-48% pumpkin powder, 0.5%-2.5% oat fiber powder and 0.4%-1.0% psyllium powder. The formulation also includes 0.6%-0.7% sodium bisulfate 0.0%-0.5% flavoring and 0.1%-0.25% potassium sorbate. The ingredients are mixed together to form a puree consistency.