Abstract: Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: 1

Abstract: Compounds of formula (I) are disclosed which are vitronectin receptor antagonists useful in the treatment of osteoporosis.

Abstract: True-tilting pad of journal bearing has face with border region including engagement surface and defining pocket with generally longitudinal sidebars and a bottom. The pad has leading and trailing portions, with the face extending generally longitudinally therebetween. The leading and trailing portions can be positioned upstream and downstream, respectively, relative to rotation direction of rotatable shaft having convex surface. The pad is pivotally supported by (e.g., mechanical and/or hydrostatic) pivot and can cooperate with one or more other pads and fluid within housing to hydrodynamically and mechanically support the shaft. The pad tilts free of mechanical engagement with other pads. The leading portion can define an entrance to the pocket and the sidebars can converge along the rotation direction.

Abstract: This invention relates to certain tricyclic compounds that are integrin receptor antagonists.

Abstract: Compounds of formula (I) are disclosed, wherein: A is a fibrinogen antagonist template; W is a linking moiety of the form --(CHR.sup.g).sub.a --U--(CHR.sup.g).sub.b --V--; Q.sup.1, Q.sup.2, Q.sup.3 and Q.sup.4 are independently N or C--R.sup.y, provided that no more than one Q.sup.1, Q.sup.2, Q.sup.3 and Q.sup.4 is N; R' is H or C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-6 -alkyl or Ar--C.sub.0-6 alkyl; R.sup.g is H or C.sub.1-6 alkyl, Het-C.sub.0-6 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-6 alkyl or Ar--C.sub.0-6 alkyl; R.sup.k is R.sup.g, --C(O)R.sup.g or --C(O)OR.sup.g R.sup.i is H, C.sub.1-6 alkyl, Het-C.sub.0-6 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-6 alkyl, Ar--C.sub.0-6 alkyl, Het-C.sub.0-6 alkyl--U'--C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-6 alkyl--U'--C.sub.1-6 alkyl or Ar--C.sub.0-6 alkyl--U'--C.sub.1-6 alkyl; R.sup.y is H, halo, --OR.sup.g, --SR.sup.g, --CN, --NR.sup.g R.sup.k, --NO.sub.2, --CF.sub.3, CF.sub.3 S(O).sub.r, --CO.sub.2 R.sup.g, --COR.sup.g or --CONR.sup.g.sub.2, or C.sub.

Abstract: This invention relates to certain tricyclic compounds that are integrin receptor antagonists.

Abstract: The invention provides a process for preparing aminophosphonic acids comprising contacting an aminophosphonate ester with a base in the presence of a hydrolysis facilitator selected from the group consisting of CO.sub.2, CS.sub.2 and COS. In one embodiment, the aminophosphonate ester is first prepared by contacting an amine, trialkylphosphite, base and formaldehyde.

Abstract: Compounds of formula (I) ##STR1## wherein A.sub.1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R.sup.3 or R.sup.4 ; X.sup.1 --X.sup.2 is CHR.sup.1 --CH, CR.sup.1 .dbd.CH, NR.sup.1 --CH, S(O).sub.u --CH or O--CH; X.sup.3 is CR.sup.5 R.sup.5 ', NR.sup.5, S(O).sub.u or O; R.sup.2 is --OR', --NR'R", --NR'SO.sub.2 R'", --NR'OR', --OCR'.sub.2 C(O)OR', --OCR'.sub.2 OC(O)--R', --OCR'.sub.2 C(O)NR'.sub.2, CF.sub.3 or --COCR'.sub.2 R.sup.2 '; R.sup.3, R.sup.4 and R.sup.7 are independently H, halo, --OR.sup.12, --SR.sup.12, --CN, --NR'R.sup.12, --NO.sub.2, --CF.sub.3, CF.sub.3 S(O).sub.r --, --CO.sub.2 R', --CONR'.sub.2, R.sup.14 --C.sub.0-6 alky-, R.sup.14 --C.sub.1-6 oxoalkyl-, R.sup.14 --C.sub.2-6 alkenyl-, R.sup.14 --C.sub.2-6 alkynyl-, R.sup.14 --C.sub.0-6 alkyloxy-, R.sup.14 --C.sub.0-6 alkylamino- or R.sup.14 --C.sub.0-6 alkyl--S(O).sub.r --; R.sup.6 is W--(CR'.sub.2).sub.q --Z--(CR'R.sup.10)--U--(CR'.sub.2).sub.s --V-- or W'--(CR'.sub.2).sub.

Abstract: A metering apparatus 10 for continuously supplying a specified amount of fluid material F to a desired surface. The apparatus 10 includes a reservoir 14 for maintaining a supply of fluid material, a housing 16 having a central bore 22 therethrough, a receiving opening 24 for receiving fluid material from the reservoir 14 to central bore 22, and an exit opening 26 through which fluid material exits the housing 16. A rotatable screw member 28 is provided engaged through the housing 16 within said central bore 22, and a driver 37 engaged with the screw member for rotating the screw member within the bore at between approximately 1 rpm to 2,700 rpm, and preferably approximately 1,750 rpm, in order to continuously supply fluid to the exit opening 26. At this operating level, fluid material is provided from the exit opening 26 at a flow rate of between approximately 1 to 23 grams/min, and in a thickness of approximately 0.001 to 8 mils.

Abstract: An assembly and method for processing extrudate material containing curves or angles into a predetermined overall configuration, including having a die assembly for an extruder which assembly controls the cross-sectional shape or profile of the extrudate and selectively varies the path of the extrudate as it leaves the die assembly. A support member is provided which has a predetermined overall configuration and profile to receive the extrudate and maintain its configuration. A driving apparatus is also provided for continuously driving either the support member or the die assembly relative to the other while the extrudate is being received in the support member, and until the entire predetermined overall configuration has been completed. The path of the extrudate is variably directed by the die assembly as it leaves the extruder in coordination with the relative speeds involved to conform the extrudate configuration to the predetermined overall configuration of the support member.

Abstract: Novel boronic acid and ester and carboxyl-modified amino acid compounds of the Formula I, which are inhibitors of trypsin-like enzymes, are disclosed :R.sup.1 --Z--CHR.sup.2 --A,where R.sup.1, Z, R.sup.2 and A are defined within.

Abstract: An improved apparatus and method for determining the existence and severity of a crack in a shaft system is provided. The apparatus includes means for mounting multiple vibration responsive output transducers around an outer circumference of the shaft system, allowing simultaneous measurements of vibrational response of the shaft system when multiple vibration responsive output transducers are mounted to the mounting means. In a first approach, the mounting means comprises a collar having two connected arcuate members, with drilled milled and tapped apertures for mounting radial input and output transducers. Torsional input and output transducers may also be mounted tangentially on the collar in drilled milled and tapped heads of bolts used to connect the two arcuate members.

Abstract: The present invention relates to 5H-[1,2]benzisothiazolo[2,3-a]quinoline-5-ones, pharmaceutical compositions thereof and to methods of using these compounds for the treatment of inflammatory disorders.

Abstract: A radiation detection system determines the type of nuclear radiation received in a detector by producing a correlation value representative of the statistical cross correlation between the shape of the detector signal and pulse shape data previously stored in memory and characteristic of respective types of radiation. The correlation value is indicative of the type of radiation. The energy of the radiation is determined from the detector signal and is used to produce a spectrum of radiation energies according to radiation type for indicating the nature of the material producing the radiation.

Abstract: A heart pump having a housing with a central longitudinal axis, inlet means and an outlet means is disclosed. A stationary shaft extends axially within the housing and the means are provided for supporting the shaft centrally located within the housing. A stator assembly is mounted about the stationary shaft and a shell assembly is rotatable about the stator assembly and shaft. The shell assembly is located between the housing and stator assembly and includes a spiral ridge located on the outerside thereof for pumping blood through the housing between the housing and shell assembly as the shell assembly rotates. Rotor laminations are located on an innerside of the shell assembly. The rotor laminations have a plurality of axially extending permanent magnets therebetween which are circumferentially spaced about the stationary shaft. A damper winding means is mounted within the rotor laminations. Blood may flow between the shell assembly and housing without exposure to magnetic fields.

Abstract: A rotor for a dynamoelectric machine, without windings and rotatable about a central longitudinal axis, having an axially extending rotatable body and a toroidal magnet coaxially mounted on the body is constructed to provide magnetic exitation for the rotor. The rotatable body contains a first set of circumferentially spaced axially extending salient poles with circumferentially spaced recesses therebetween and a second set of similar poles at an opposite axial location. The toroidal magnet is coaxially mounted on the body between the first and second set of salient poles. A second toroidal magnet may also be mounted on the body and a magnetic spacer placed in between both toroidal magnets.

Abstract: The present invention relates to novel 5H-[1,2]benzisothiazolo[2,3-a]quinoline-5-ones, processes for preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods of using these compounds for the treatment of inflammatory disorders.

Abstract: A die assembly (10) for controlling extrudate profile dimension. The die assembly includes a die block (12) having a feed passage (16) for movably supporting a diverter member (13) within the die block, and first and second die block passages (18, 20). The diverter member (13) includes a diverter passage (32) and first and second feed openings (34, 36) interconnected by the diverter passage. One of the first or second feed openings (34, 36) has a larger diameter than the other of the first or second feed openings. The diverter member (13) is movable with respect to the die block (12) for directing extrudate flow via the diverter passage (32) through the second die block passage (20), to thereby vary the profile dimension of the extrudate exiting the die block. The die block (12) additionally includes a disposal passage (22).

Abstract: An improved process for dehydrating dialkyl 2,6-bis(trifluoromethyl)-2,6-dihydroxy-4-(alkyl)-3,5-piperidinedicarboxyla tes using concentrated sulfuric acid essentially in the absence of a solvent to prepare the corresponding dialkyl 2,6-bis(trifluoromethyl)dihydro-4-(alkyl)-3,5-pyridinedicarboxylates.

Abstract: The presence, size and location of a crack in a shaft is determined by comparing actual measured natural frequencies of the operating shaft system with the results of an analytical model. From a multi-station analytical model of an uncracked operating shaft system, natural frequencies and associated mode shapes are derived. A suspected axial location of a crack is defined, and a natural frequency of interest is selected which has an associated mode shape exhibiting significant localized bending at the suspected axial location of the crack and at a site of response measurement. The analytical model is modified to include a representation of an asymmetric crack at the suspected crack location. A predicted split and downward shift of a lateral natural frequency of interest as a function of crack depth and/or a predicted downward shift of a torsional natural frequency of interest as a function of crack depth is calculated from the modified model.