Abstract: The present invention provides compositions and methods for combination therapy comprising administering to a patient in need thereof, drug-resistant immunotherapy, immune checkpoint inhibitors, and chemotherapy for the treatment of cancer.

Abstract: Output devices or systems, such as televisions, speakers, projectors, or output controllers, are herein disclosed and enabled for wirelessly receiving digital content from a digital content service or from an information apparatus. The disclosed output device includes wireless communication circuitry and an interface. To set up the output device for receiving and playing the digital content, the output device first receives, via the interface, security information, and then establishes a wireless local area network connection. Subsequent to having established the wireless local area network connection, the output device connects to a server over a network, using the wireless communication circuitry, for downloading and installing software applications or software components for upgrading or modifying the capabilities of the output device.

Abstract: An integrated circuit device that includes a secure or protected memory component is herein disclosed and enabled. The integrated circuit may be a wireless communication device or a smart card or an USB device. Additionally, the integrated circuit may be part of, or in, a computing device or mobile device. The integrated circuit device includes a protected memory section for storing protected data that is not accessible by a user at the protected memory section, but is accessible by a memory controller included in the integrated circuit device. The memory controller accesses the protected data with a combination of security operations that may include cryptography. The integrated circuit device may further include a wireless component for establishing a wireless connection with wireless computing devices or readers for wirelessly transmitting the protected data accessed by the memory controller to the wireless computing devices or the readers.

Abstract: Information apparatus (e.g., smart phone, Internet appliances, information pad, display devices) with software applications for receiving digital content from a service provided over a network (e.g., Internet) and for wirelessly playing at least part of the received digital content at a wireless output device (e.g., a Bluetooth enabled device) are herein disclosed and enabled. To receive and play the digital content, the software applications may obtain authentication information for accessing the service, receive a list of one or more digital content that is available from the service for selection on a touch sensitive screen, receive selected digital content from the list displayed on the touch sensitive screen, receive output data from the service related to the selected digital content, and then either play audio data related to the received output data at a speaker of the information apparatus or wirelessly play the audio data at the wireless output device.

Abstract: Software applications and information apparatus supporting output of digital content over a network (e.g., Internet) to an output device (e.g., printer) are herein disclosed and enabled. To output digital content, an application for accessing a service provided over the network is installed at the information apparatus, the information apparatus discovers the output device that is in the same local area network (e.g., via IEEE 802.11) as the information apparatus, output device information is received from the discovered output device, and the output device information is transmitted to the service for registering the output device. Subsequent to registration, an application (e.g., Internet browser, email, document) at the information apparatus, having appropriate security or authentication information, may transmit digital content to the service to output the digital content at the registered output device.

Abstract: Information apparatus and application software supporting printing over air or network are herein disclosed and enabled. The information apparatus may include one or more software components that include (1) a discovery component to discover a supported printer in a local area network (LAN) and to receive device information related to the printer (e.g., capability, language or format supported, identification) from the printer, and (2) a printing component to generate or obtain print data based on the device information received and to transmit the print data to the discovered printer. After establishing the connection to the LAN, application software (e.g., Internet browser, email, photos, documents) in the information apparatus may print digital content by using the discovery component to discover the printer in the LAN, and may use the printing component to obtain and transmit print data in a form that is acceptable to the printer for printing the digital content.

Abstract: A secure file transfer system and a secure file transfer method for routing an electronic file or a high-definition facsimile translated from the electronic file, from a sending computing device over a digital electronic communication network to a receiving computing device. The method may include receiving, from the sending computing device, an electronic package including a modified destination identifier including a domain associated with a secure file transfer system. The electronic package may include an electronic file as an attachment. The modified destination identifier may be a modified email address having one or more other characters substituted for an original at-symbol.

Abstract: An information apparatus that supports a touch sensitive screen for managing e-mails is disclosed and enabled. The information apparatus may include a graphical user interface, an e-mail application, an Internet browsing application, and applications for playing audio/video content. The information apparatus includes an operating system software and support for installation of new applications. In one example, a user of the information apparatus may reply to an e-mail by selecting an item over the touch sensitive screen. The user may scroll down or up an email using the touch sensitive screen. In other examples, the user may further select an item or functional control via the touch sensitive screen to output, synchronize, stream, transmit, play, print, display, or mirror at least part of digital content from the information apparatus to one or more output devices over air.

Abstract: Information apparatus specifications that include voice activated command functions are disclosed and enabled. The information apparatus may include a touch sensitive screen, a digital camera, a wireless communication unit, an operating system, a graphical user interface, an e-mail application, an Internet browsing application, and an application for playing audio or video content. The information apparatus operating system supports an application programming interface (API). A user can install additional applications. The information apparatus may further include a microphone and a speaker for interacting via voice commands with the user. In some examples, the user may take a picture with the digital camera included in the information apparatus and transfer or synchronize the picture to a wireless output device. In other examples, the information apparatus may further wirelessly play, print, stream, or mirror digital content, via the touch sensitive screen, to an output device.

Abstract: A method for capturing and outputting digital content is herein disclosed and enabled, the output system includes an information apparatus, a server, and a client device. The information apparatus includes at least a digital camera and a wireless communication module (e.g., IEEE 802.11 or Bluetooth). The server is accessible by the client device over a network. The information apparatus, using the digital camera, captures digital content and transmits, over the Internet and using the wireless communication module, the digital content to the server for storage. The server generates output data from at least part of the digital content stored at the server, and provides the generated output data from the server to the client device that has security or authentication information for accessing the server. The client device outputs or plays at least part of the digital content at an output device associated with the client device.

Abstract: A method for establishing a wireless connection between a mobile information apparatus (e.g., smart phone) and an output system (e.g., audio output device) are herein disclosed and enabled. The method comprises using an interface of the output system to receive an indication from a user, and initiating wireless discovery based, at least in part, on physical proximity between the mobile information apparatus and the output system, subsequent to receiving the user indication. The method additionally comprises using the mobile information apparatus to wirelessly (1) discover the output system, (2) establish a wireless communication link between the mobile information apparatus and the output system, and (3) transmit audio output data from the mobile information apparatus to the output system over the established wireless communication link. Subsequently, the output system outputs or plays at least part of the wireles sly received audio output data from the mobile information apparatus.

Abstract: Output devices (or output controllers connectable to an output device) that establish a wireless connection with an information apparatus are herein disclosed and enabled. An output device may be an audio output device, a printer, a television, a projector, or a display device. The output device may include one or more chips or chipsets that are compatible with Bluetooth or IEEE 802.11 standards. The output device is operable to: wirelessly announce its availability for the information apparatus to wirelessly discover the output device when the information apparatus is within a limited physical distance to the output device; wirelessly transmit one or more device attributes related to the output device from the output device to the information apparatus that has wirelessly discovered the output device; and wirelessly receive, from the information apparatus, output data that is in accordance, at least in part, to the one or more device attributes.

Abstract: An integrated circuit device that includes a wireless component and a secure element is herein disclosed and enabled. The integrated circuit device includes a protected memory area for storing protected data that is implemented to be not accessible by a user, but is accessible by a memory controller included in the integrated circuit device. The memory controller accesses the protected data with a combination of security operations that may include cryptography, decryption, or encryption. The integrated circuit device further includes a wireless interface for establishing a short range wireless point-to-point communication with wireless computing devices or readers for transmitting the protected data that is encrypted. The integrated circuit device functions as a security key requiring the presence of the integrated circuit device when accessing and using the protected data. The wireless integrated circuit device can be included in, or embodied as, any wireless communication device, such as a smart phone.

Abstract: Digital content services provided over the Internet for transmitting or streaming protected digital content to client or output devices are herein disclosed and enabled. The protected digital content is encrypted and device dependent or specific for rendering or playing at a limited number of devices, including smart phones, information pads, audio players, wireless controllers, televisions, printers, etc. To illustrate, a client may include an application for accessing digital content from a subscribed content service or store over the Internet. To access the digital content, a client application may send, to the content service or store, authentication information, subscription information, and/or a reference to selected digital content. The service then generates encrypted device dependent output data, related to the selected digital content and associated with a device previously registered with the service, for transmitting or streaming to the client or output devices (e.g.

Abstract: A method for capturing and outputting digital content is herein disclosed and enabled, the output system includes an information apparatus, a server, and a client device. The information apparatus includes at least a digital camera and a wireless communication module (e.g., IEEE 802.11 or Bluetooth). The server is accessible by the client device over a network. The information apparatus, using the digital camera, captures digital content and transmits, over the Internet and using the wireless communication module, the digital content to the server for storage. The server generates output data from at least part of the digital content stored at the server, and provides the generated output data from the server to the client device that has security or authentication information for accessing the server. The client device outputs or plays at least part of the digital content at an output device associated with the client device.

Abstract: Information apparatus (e.g., a smart phone) for outputting digital content, stored in the information apparatus, at an output device is herein disclosed and enabled. The information apparatus includes wireless communication circuitry for discovering one or more output devices based, at least in part, on physical proximity and short range wireless communication. Subsequent to wirelessly discovering the output devices, the information apparatus receives device dependent attributes from the discovered output devices and provides, on a touch sensitive screen interface, at least an item related to the discovered output device for selection. The device dependent attributes include information related to the output devices. After the output device is selected, the information apparatus generates output data from the digital content that is acceptable for rendering at the output device; and wirelessly transmits the generated output data to the selected output device for rendering at least part of the digital content.

Abstract: An information apparatus (e.g., Internet appliance, information pad) and software applications of the information apparatus that includes digital camera or video camera and supporting voice commands for receiving and playing digital content from a service provided over a network (e.g., Internet) are herein disclosed and enabled. The mobile information apparatus may establish a wireless local area network connection to access a service over the Internet. The service may be a subscribed service. While connected to the service, the mobile information apparatus may capture, using the digital camera or video camera, digital content that includes the image or the video; send the captured the digital content to the service; and, thereafter receives, from the service, output data related to the digital content for outputting or playing at display device associated with the information apparatus.

Abstract: An output system for capturing and outputting digital content is herein disclosed and enabled. The output system includes an information apparatus (e.g., a digital capturing device or an internet appliance) for capturing digital content, a server application at a server over the Internet, and a client application at a client device for accessing the captured digital content. The information apparatus includes a wireless communication module (e.g., IEEE 802.11 or Bluetooth) for transmitting the captured digital content to the server. The server application generates output data from the captured digital content for sending to the client device for outputting or playing at least part of the output data at an output device associated with the client device. Receipt of the output data is dependent on the client application having provided security or authentication information and payment or subscription information to the server.

Abstract: An information apparatus that wirelessly discovers an available output device, within a physical vicinity, for outputting content is herein disclosed and enabled. The information apparatus includes a wireless communication unit for establishing short range wireless communication directly between the information apparatus and one or more available output devices; wirelessly receiving information from an available output device; determining, from the information received from the available output device, whether the available output device matches a requirement for outputting the content; and, when the requirement is matched, selecting the available output device, conforming at least part of the content into output data, and transmitting at least part of the output data over the short range wireless communication directly from the information apparatus to the selected output device. The information apparatus may include one or more of a smart phone, information pad, a digital camera, or an Internet appliance.

Abstract: A portable electronic device configured for receiving voice activated commands for wirelessly managing or driving an output device. The output device may include, for example, a television, a controller connectable to a television, a printer, an audio output device, or a projector. The portable electronic device includes an interface that includes at least one button or other controls, a microphone, and wireless communication circuitry. Subsequent to establishing, within a physical proximity, a wireless connection to the output device using the wireless communication circuitry, the portable electronic device is operable for receiving an indication from a user via the interface, for wirelessly sending information to the output device related to the indication, and for wirelessly receiving data or component from the output device in response to having sent the information. Additionally, the portable electronic device is configured to receive voice activated commands from the user via the microphone.