Patents by Inventor William J. Hoekstra

William J. Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11247981
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: February 15, 2022
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Robert J. Schotzinger, Stephen W. Rafferty
  • Publication number: 20210360921
    Abstract: The present invention relates to compounds of Formula (I): wherein R1 is as defined herein, or an acceptable salt, solvate, prodrug or hydrate thereof. The compounds of Formula I are inhibitors of metalloenzymes, such as lanosterol demethylase (CYP51).
    Type: Application
    Filed: June 3, 2021
    Publication date: November 25, 2021
    Applicant: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates, Robert J. Schotzinger, Michael R. Loso, Gary D. Gustafson, Michael T. Sullenberger, Kimberly Steward, Javier Delgado, Xuelin Wang
  • Publication number: 20210322409
    Abstract: Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: June 17, 2021
    Publication date: October 21, 2021
    Inventors: Steven SPARKS, Christopher M. YATES, Sammy R. SHAVER, William J. HOEKSTRA
  • Patent number: 11051514
    Abstract: The present invention relates to compounds of Formula (I): wherein R1 is as defined herein, or an acceptable salt, solvate, prodrug or hydrate thereof. The compounds of Formula I are inhibitors of metalloenzymes, such as lanosterol demethylase (CYP51).
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: July 6, 2021
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates, Robert J. Schotzinger, Michael R. Loso, Gary D. Gustafson, Michael T. Sullenberger, Kimberly Steward, Javier Delgado, Xuelin Wang
  • Patent number: 11040034
    Abstract: Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: June 22, 2021
    Assignee: PHASEBIO PHARMACEUTICALS, INC.
    Inventors: Steven Sparks, Christopher M. Yates, Sammy R. Shaver, William J. Hoekstra
  • Patent number: 10919874
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders, or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: February 16, 2021
    Assignee: NQP 1598, LTD.
    Inventors: William J. Hoekstra, Christopher M. Yates
  • Patent number: 10836740
    Abstract: The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7 or 7* and 11 or 11* and substituted derivatives thereof.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: November 17, 2020
    Assignee: MYCOVIA PHARMACEUTICALS, INC.
    Inventors: David Dale Wirth, Christopher M. Yates, William J. Hoekstra, Martin F. Bindl, Eduard Hartmann
  • Patent number: 10745378
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: August 18, 2020
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates
  • Publication number: 20200247779
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: January 6, 2020
    Publication date: August 6, 2020
    Inventors: William J. HOEKSTRA, Robert J. SCHOTZINGER, Stephen W. RAFFERTY
  • Patent number: 10676459
    Abstract: The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: June 9, 2020
    Assignee: MYCOVIA PHARMACEUTICALS, INC.
    Inventors: William J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud
  • Publication number: 20200024252
    Abstract: The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7 or 7* and 11 or 11* and substituted derivatives thereof.
    Type: Application
    Filed: July 1, 2019
    Publication date: January 23, 2020
    Inventors: David Dale WIRTH, Christopher M. YATES, William J. HOEKSTRA, Martin F. BINDL, Eduard HARTMANN
  • Patent number: 10526312
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: January 7, 2020
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Robert J. Schotzinger, Stephen W. Rafferty
  • Patent number: 10513505
    Abstract: The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, and/or a compound of 14 or 14*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7, 7* and 11, 11* and substituted derivatives thereof.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: December 24, 2019
    Assignee: NQP 1598, LTD.
    Inventors: David Dale Wirth, Christopher M. Yates, William J. Hoekstra
  • Publication number: 20190382370
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders, or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: July 31, 2019
    Publication date: December 19, 2019
    Inventors: William J. Hoekstra, Christopher M. Yates
  • Publication number: 20190367476
    Abstract: The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: August 20, 2019
    Publication date: December 5, 2019
    Applicant: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud
  • Patent number: 10464922
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: November 5, 2019
    Assignee: NQP 1598, Ltd.
    Inventors: Christopher M. Yates, Sammy R. Shaver, William J. Hoekstra
  • Patent number: 10464921
    Abstract: The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7, 7* and 11, 11* and substituted derivatives thereof.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: November 5, 2019
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: David Dale Wirth, Christopher M. Yates, William J. Hoekstra, Martin F. Bindl, Eduard Hartmann
  • Patent number: 10428025
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: October 1, 2019
    Assignees: Mycovia Pharmaceuticals, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Patent number: 10421741
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: September 24, 2019
    Assignees: Mycovia Pharmaceuticals, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Patent number: 10414751
    Abstract: The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: September 17, 2019
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud