Patents by Inventor William J. Hoekstra

William J. Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal compound process
    Patent number: 10173998
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: January 8, 2019
    Assignees: Mycovia Pharmaceuticals, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Metalloenzyme inhibitor compounds as fungicides
    Patent number: 10167300
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: January 1, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • ANTIFUNGAL COMPOUNDS AND PROCESSES FOR MAKING
    Publication number: 20180319768
    Abstract: The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: December 8, 2017
    Publication date: November 8, 2018
    Inventors: William J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud
  • METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES
    Publication number: 20180298038
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: March 7, 2018
    Publication date: October 18, 2018
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES
    Publication number: 20180290998
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: April 4, 2018
    Publication date: October 11, 2018
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • Metalloenzyme inhibitor compounds
    Patent number: 10085984
    Abstract: Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: October 2, 2018
    Assignee: Viamet Pharmaceuticals (Bermuda), Ltd.
    Inventors: Steven Sparks, Christopher M. Yates, Sammy R. Shaver, William J. Hoekstra
  • Antifungal compound process
    Patent number: 10077250
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: September 18, 2018
    Assignees: Mycovia Pharmaceuticals, Inc., Tlie United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20180258068
    Abstract: The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, and/or a compound of 14 or 14*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7, 7* and 11, 11* and substituted derivatives thereof.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 13, 2018
    Inventors: David Dale Wirth, Christopher M. Yates, William J. Hoekstra
  • METALLOENZYME INHIBITOR COMPOUNDS
    Publication number: 20180221364
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: April 3, 2018
    Publication date: August 9, 2018
    Inventors: William J. Hoekstra, Robert J. Schotzinger, Stephen W. Rafferty
  • METALLOENZYME INHIBITOR COMPOUNDS
    Publication number: 20180222884
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: April 9, 2018
    Publication date: August 9, 2018
    Inventors: William J. Hoekstra, Christopher M. Yates
  • Antifungal compound process
    Patent number: 10017494
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: July 10, 2018
    Assignees: Mycovia Pharmaceuticals, Inc., The United States of America, as represented by the Department of Health and Human Services
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • METALLOENZYME INHIBITOR COMPOUNDS
    Publication number: 20180185362
    Abstract: Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: December 29, 2017
    Publication date: July 5, 2018
    Inventors: Steven Sparks, Christopher M. Yates, Sammy R. Shaver, William J. Hoekstra
  • Antifungal compound process
    Patent number: 10000465
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: June 19, 2018
    Assignees: Mycovia Pharmaceuticals, Inc., U.S. Department of Health and Human Services
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-TETRAZOL-1-YL)PROPAN-2-OLS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20180155324
    Abstract: Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and 1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-substituted-pyridin-2-yl)ethanones and processes for their preparation.
    Type: Application
    Filed: February 1, 2018
    Publication date: June 7, 2018
    Inventors: William J. Hoekstra, Nakyen Choy, Carl DeAmicis, Daniel Knueppel, Jim Renga, Michael T. Sullenberger, Gregory Whiteker, Yuanming Zhu, Gary D. Gustafson
  • 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
    Patent number: 9988365
    Abstract: Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and 1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-substituted-pyridin-2-yl)ethanones and processes for their preparation.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: June 5, 2018
    Assignee: VPS-3, Inc.
    Inventors: William J. Hoekstra, Nakyen Choy, Carl DeAmicis, Daniel Knueppel, Jim Renga, Michael T. Sullenberger, Gregory Whiteker, Yuanming Zhu, Gary D. Gustafson
  • Antifungal compound process
    Patent number: 9981943
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: May 29, 2018
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Metalloenzyme inhibitor compounds as fungicides
    Patent number: 9957252
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: May 1, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • Metalloenzyme inhibitor compounds as fungicides
    Patent number: 9944664
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: April 17, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • Metalloenzyme inhibitor compounds
    Patent number: 9938255
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: April 10, 2018
    Assignee: VPS-3, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates
  • 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
    Patent number: 9914726
    Abstract: Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: March 13, 2018
    Assignee: VPS-3, INC.
    Inventors: William J. Hoekstra, Daniel Knueppel, Jim Renga, Gregory Whiteker, Michael T. Sullenberger