Abstract: The present application is directed to immunomodulatory compositions comprising invariant NKT cell (iNKT cell) agonist compounds that induce expansion of tissue resident memory T-cells (Trm Cells) in combination with an immune stimulator agent that enhances an immune response to a target antigen or a polynucleotide encoding the immune stimulator. The iNKT agonists are ?-GalCer analogue compounds modified at the 6 position of the galactose ring. The immune stimulator is an antigen or an mRNA encoding an antigen to create a vaccine formulation. These combinations are used in the treatment of infection or cancer in a subject, or to enrich the number of Trm cells in the liver of a subject.

Abstract: A system and a method are disclosed for detecting that a requesting user is transmitting a request to a recipient user to perform one or more tasks with respect to a secure document. The system extracts features associated with the secure document and inputs the features into a machine learning model that outputs one or more probabilities corresponding to a potential failure of the request. Based on the one or more probabilities, the system generates one or more feature modification activities to improve a likelihood of the recipient user completing the request. The system provides the one or more feature modification activities to at least one of the requesting user and the recipient user.

Abstract: A method includes: receiving system data corresponding to an engine system. The system data includes a plurality of remaining useful life (RUL) values with each RUL value associated with a component of the engine system. The method further includes: comparing a first RUL value to a service interval threshold; generating a near-term service recommendation including a first list of components that correspond to each RUL value that are less than or equal to the service interval threshold; generating an extended term service recommendation including a second list of components and a downtime prediction; generating a coordinated service recommendation by dynamically populating one or more fields of the coordinated service recommendation based on the near-term service recommendation and the extended term service recommendation; and providing the combined service recommendation to a user device.

Abstract: Systems and methods for determining a remaining useful life (RUL) of a component of an engine system are provided. A method includes: receiving component data comprising sensor data corresponding to a component and engine data; pre-processing the component data by removing a first set of sensor data values that correspond to a first set of engine data values of the engine data; aggregating the pre-processed component data by grouping a second set of sensor values of the sensor data; determining a RUL for the component based on a RUL model that correlates at least a portion of the aggregated data to RUL values; adjusting the RUL based on at least one of detecting a service event or determining that one or more sensor data values of the sensor data are outside a predetermined range of values; and providing the RUL to a user device.

Abstract: A repair prosthetic for repairing a hernia is disclosed. In some embodiments, the repair prosthetic includes a patch body, a frame that assists in spreading the patch body from a reduced configuration to an expanded configuration, and a plurality of tethers attached to the patch body at locations between the frame and a periphery of the patch body. In various embodiments, the tethers can be tensioned to mitigate curling or creasing in the patch body to flatten the patch to facilitate attachment to tissue.

Abstract: A repair prosthetic for repairing a hernia is disclosed. In some embodiments, the repair prosthetic includes a patch body, a frame that assists in spreading the patch body from a reduced configuration to an expanded configuration, and a plurality of tethers attached to the patch body at locations between the frame and a periphery of the patch body. In various embodiments, the tethers can be tensioned to mitigate curling or creasing in the patch body to flatten the patch to facilitate attachment to tissue.

Abstract: Spark plugs are disclosed that include electrode arrangements to improve the charge flow into and out of the annular volume around the insulator nose and a pre-chamber volume of a pre-chamber device, thus directing a purge of exhaust gases trapped in the annular volume to a space formed by the exterior of the spark plug body and the interior of the pre-chamber device.

Abstract: A repair prosthetic for repairing a hernia is disclosed. In some embodiments, the repair prosthetic includes a patch body, a frame that assists in spreading the patch body from a reduced configuration to an expanded configuration, and a plurality of tethers attached to the patch body at locations between the frame and a periphery of the patch body. In various embodiments, the tethers can be tensioned to mitigate curling or creasing in the patch body to flatten the patch to facilitate attachment to tissue.

Abstract: A repair prosthetic for repairing a hernia is disclosed. In some embodiments, the repair prosthetic includes a patch body, a frame that assists in spreading the patch body from a reduced configuration to an expanded configuration, and a plurality of tethers attached to the patch body at locations between the frame and a periphery of the patch body. In various embodiments, the tethers can be tensioned to mitigate curling or creasing in the patch body to flatten the patch to facilitate attachment to tissue.

Abstract: Embodiments of the disclosure include pneumatic tires having improved snow performance. Said tires include a cap ply extending at least partially across a full width of at least one of the belt plies and having a rupture force greater than 210 N per 15 mm of cap ply width. A shoulder rib includes a compliance groove or sipe extending primarily in a circumferential direction and to a depth equal to or less than 75% of the skid depth. The lateral sipes and grooves are arranged to provide an average lateral feature spacing of less than 15 mm. The average inclination angle for the lateral grooves is greater than 6 degrees in the shoulder ribs and is greater than 20 degrees in the central ribs. A longitudinal non-lateral sipe edge density is greater than 21.1 micrometers/mm2. A longitudinal lateral sipe edge density for all lateral sipes is greater than 5.5 micrometers/mm2.

Abstract: A combustion pre-chamber assembly includes pre-chamber device body defining an annular plenum that is in fluid communication with the at least one bore that extends through the spark plug shell. The annular plenum is also in communication with at least one purging passage that extends from the annular plenum to an end surface of the pre-chamber device body. Residual exhaust gases in the annular volume of the spark plug are purged by fresh charge flow from the main combustion chamber as the piston approaches top dead center. The fresh charge flow that is provided to the annular plenum through the at least one purging passage and into the annular volume of the spark plug through the at least one bore through the spark plug shell.

Abstract: A client node (CN) requests content from an access node (AN). Rule set ACR_CN is provided to CN and AN and ACR_AN is used by AN. A request sent by CN in violation of ACR_CN may be blocked and cause AN to block subsequent requests from CN that would be allowed per ACR_CN. A request blocked according to ACR_AN but not ACR_CN is blocked but subsequent requests may still be allowed according to ACR_CN and ACR_AN. Authenticated distribution of the ACR_CN and ACR_AN may be performed in cooperation with a controller using authenticated tokens (AT).

Abstract: A client node (CN) requests content from an access node (AN). Rule set ACR_CN is provided to CN and AN and ACR_AN is used by AN. A request sent by CN in violation of ACR_CN may be blocked and cause AN to block subsequent requests from CN that would be allowed per ACR_CN. A request blocked according to ACR_AN but not ACR_CN is blocked but subsequent requests may still be allowed according to ACR_CN and ACR_AN. Authenticated distribution of the ACR_CN and ACR_AN may be performed in cooperation with a controller using authenticated tokens (AT).

Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture that can include, and/or a method for activities that can include and/or relate to, an elongate flexible strap and a plurality of elongate finger steps, each elongate finger step from the plurality of finger steps attached to the strap.

Abstract: Embodiments of the disclosure include a pneumatic tire having improved high speed limits while generally maintaining wear, traction, and handling performance. Said tires include a cap ply extending substantially across a full width of at least one of the belt plies and being arranged at least partially within each shoulder, the cap ply forming a layer of elastomeric material reinforced with a plurality of elongate reinforcements spaced apart in an array, the cap ply being characterized as having a rupture force greater than 210 N per 15 mm of the cap ply width. In each shoulder area of said tires, the tread is characterized as being flatter and having a greater tread thickness.

Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.

Abstract: The present invention concerns a method for manufacturing a proppant for a particular stimulation fluid, or for manufacturing a stimulation fluid for a particular proppant. The present invention also concerns a proppant for hydrocarbon stimulation, wherein the proppant comprises a plurality of amorphous spherical glass particles which have not undergone any further chemical or thermal treatment, a method of preparing the proppant, and uses of the proppant in hydrocarbon stimulation.

Abstract: A method is provided by which a network adapter device receives a packet sent over a network from a peer, the packet including an enqueue timestamp indicating when the packet has been enqueued at the network adapter device. The network adapter device parses a header of the packet to detect whether the header includes bits indicating that the peer device is experiencing congestion, and obtains packet metadata of the packet and the enqueue timestamp of the packet. The network adapter device compares the packet metadata with information in a flow table to identify an entry in the flow table corresponding to a flow to which the packet metadata matches. The network adapter device sets a timer associated with the flow, the timer for use in scheduling transmission of a next packet provided by the host to be sent to the peer.

Abstract: The present invention is directed to a process for the purification of ethylene glycol from a crude stream thereof.

Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.