Patents by Inventor William Marshall

William Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11028064
    Abstract: Disclosed are tricyclic heterocyclic compounds having kinase inhibitory activity, pharmaceutical compositions and kits comprising the compounds, and use of the compounds in the treatment of or in medicaments for the treatment of various diseases and conditions. In particular, disclosed are tricyclic heterocyclic compounds of the formula (I) having CSF-1R (c-FMS kinase) inhibitory activity and their use in the treatment of various diseases and conditions, such as those mediated by CSF-1R, including proliferative or neoplastic diseases and conditions, including cancers, and bone, inflammatory, and autoimmune diseases and conditions.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 8, 2021
    Assignee: AUCKLAND UNISERVICES LIMITED
    Inventors: Swarnalatha Akuratiya Gamage, Peter Robin Shepherd, Jack Urquhart Flanagan, Gordon William Rewcastle, Andrew James Marshall, Christina Maree Buchanan, Guo-Liang Lu, Muriel Bonnet, Stephen Michael Frazer Jamieson, William Alexander Denny
  • Publication number: 20210160217
    Abstract: A client node (CN) requests content from an access node (AN). Rule set ACR_CN is provided to CN and AN and ACR_AN is used by AN. A request sent by CN in violation of ACR_CN may be blocked and cause AN to block subsequent requests from CN that would be allowed per ACR_CN. A request blocked according to ACR_AN but not ACR_CN is blocked but subsequent requests may still be allowed according to ACR_CN and ACR_AN. Authenticated distribution of the ACR_CN and ACR_AN may be performed in cooperation with a controller using authenticated tokens (AT).
    Type: Application
    Filed: November 25, 2020
    Publication date: May 27, 2021
    Inventors: Lior Rozner, Alexander William Marshall, Eran Moshe Kampf, Dmitry Adamushka, Dzianis Vashchuk, Eugene Lapidous
  • Publication number: 20210160237
    Abstract: A client node (CN) requests content from an access node (AN). Rule set ACR_CN is provided to CN and AN and ACR_AN is used by AN. A request sent by CN in violation of ACR_CN may be blocked and cause AN to block subsequent requests from CN that would be allowed per ACR_CN. A request blocked according to ACR_AN but not ACR_CN is blocked but subsequent requests may still be allowed according to ACR_CN and ACR_AN. Authenticated distribution of the ACR_CN and ACR_AN may be performed in cooperation with a controller using authenticated tokens (AT).
    Type: Application
    Filed: November 25, 2020
    Publication date: May 27, 2021
    Inventors: Lior Rozner, Alexander William Marshall, Eran Moshe Kampf, Dmitry Adamushka, Dzianis Vashchuk, Eugene Lapidous
  • Patent number: 10995050
    Abstract: A process for purification of a crude product stream recovered from the production of an unsaturated carboxylic acid by an aldolization reaction is disclosed. The product stream comprises the unsaturated carboxylic acid, aldehyde, saturated carboxylic acid, water, non-condensable vapours and optionally heavy by-products. The process comprises: providing the crude product stream in the vapour phase to a first separation column operated at a temperature and pressure to form an intermediate product stream comprising product unsaturated carboxylic acid, a portion of the water from the feed stream, a portion of the saturated carboxylic acid and heavy by-products where present; and passing the intermediate product stream to a second separation column operated at a temperature and pressure such that the unsaturated carboxylic acid product is separated and recovered.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: May 4, 2021
    Assignee: Johnson Matthey Davy Technologies Limited
    Inventors: Robert Gallen, Michael William Marshall Tuck
  • Patent number: 10975759
    Abstract: A spark plug is disclosed that includes at least one bore extending through a shell of the spark plug in order to form a passageway between an annular volume around the spark plug insulator nose and a pre-chamber volume of a pre-chamber device, thus directing a purge of exhaust gases trapped in the annular volume to a space formed by the exterior of the spark plug body and the interior of the pre-chamber device.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 13, 2021
    Assignee: Cummins Inc.
    Inventors: Alan C. Anderson, William Marshall Cover, Xu Han, Benjamin L. Olivas, Daniel J. O'Connor, Daniel Guillermo Gonzalez Medina, Xiao Qin, Nicholas James Welch, Andrew Guy Kitchen
  • Patent number: 10968157
    Abstract: A process for purification of a crude product stream recovered from the production of acrylic acid by an aldolisation reaction is disclosed. The product stream comprises acrylic acid, formaldehyde, water, non-condensable vapours and optionally heavy by-products. The process comprises: providing the crude product stream in the vapour phase to a first separation column operated at a temperature and pressure to form an intermediate overhead stream comprising water, formaldehyde and methanol; and passing said intermediate overhead stream to a formaldehyde separation column operated at a temperature and pressure to enable a stream having a higher formaldehyde concentration than the formaldehyde concentration in the intermediate overhead stream to be formed and recovered from at or near the bottom of the formaldehyde separation column as a formaldehyde enriched stream.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 6, 2021
    Assignee: Johnson Matthey Davy Technologies Limited
    Inventors: Robert Gallen, Michael William Marshall Tuck
  • Patent number: 10920226
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for LDHA.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: February 16, 2021
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Publication number: 20200338930
    Abstract: Embodiments of the disclosure include pneumatic tires having improved snow performance. Said tires include a cap ply extending at least partially across a full width of at least one of the belt plies and having a rupture force greater than 210 N per 15 mm of cap ply width. A shoulder rib includes a compliance groove or sipe extending primarily in a circumferential direction and to a depth equal to or less than 75% of the skid depth. The lateral sipes and grooves are arranged to provide an average lateral feature spacing of less than 15 mm. The average inclination angle for the lateral grooves is greater than 6 degrees in the shoulder ribs and is greater than 20 degrees in the central ribs. A longitudinal non-lateral sipe edge density is greater than 21.1 micrometers/mm2. A longitudinal lateral sipe edge density for all lateral sipes is greater than 5.5 micrometers/mm2.
    Type: Application
    Filed: December 30, 2017
    Publication date: October 29, 2020
    Applicant: COMPAGNIE GENERALE DES ETABLISSMENTS MICHELIN
    Inventors: Patrick Jon Buresh, Jason Schoenmaker, Robert Dillon, Phillip William Check, William Marshall Thompson
  • Publication number: 20200331299
    Abstract: Embodiments of the disclosure include a pneumatic tire having improved high speed limits while generally maintaining wear, traction, and handling performance. Said tires include a cap ply extending substantially across a full width of at least one of the belt plies and being arranged at least partially within each shoulder, the cap ply forming a layer of elastomeric material reinforced with a plurality of elongate reinforcements spaced apart in an array, the cap ply being characterized as having a rupture force greater than 210 N per 15 mm of the cap ply width. In each shoulder area of said tires, the tread is characterized as being flatter and having a greater tread thickness.
    Type: Application
    Filed: December 30, 2017
    Publication date: October 22, 2020
    Applicant: COMPAGNIE GENERALE DES ETABLISSMENTS MICHELIN
    Inventors: Patrick Jon Buresh, Jason Schoenmaker, Robert Dillon, Phillip William Check, William Marshall Thompson
  • Publication number: 20200299217
    Abstract: A process for purification of a crude product stream recovered from the production of acrylic acid by an aldolisation reaction is disclosed. The product stream comprises acrylic acid, formaldehyde, water, non-condensable vapours and optionally heavy by-products. The process comprises: providing the crude product stream in the vapour phase to a first separation column operated at a temperature and pressure to form an intermediate overhead stream comprising water, formaldehyde and methanol; and passing said intermediate overhead stream to a formaldehyde separation column operated at a temperature and pressure to enable a stream having a higher formaldehyde concentration than the formaldehyde concentration in the intermediate overhead stream to be formed and recovered from at or near the bottom of the formaldehyde separation column as a formaldehyde enriched stream.
    Type: Application
    Filed: December 20, 2017
    Publication date: September 24, 2020
    Inventors: Robert GALLEN, Michael William Marshall TUCK
  • Publication number: 20200299221
    Abstract: A process for purification of a crude product stream recovered from the production of an unsaturated carboxylic acid by an aldolization reaction is disclosed. The product stream comprises the unsaturated carboxylic acid, aldehyde, saturated carboxylic acid, water, non-condensable vapours and optionally heavy by-products. The process comprises: providing the crude product stream in the vapour phase to a first separation column operated at a temperature and pressure to form an intermediate product stream comprising product unsaturated carboxylic acid, a portion of the water from the feed stream, a portion of the saturated carboxylic acid and heavy by-products where present; and passing the intermediate product stream to a second separation column operated at a temperature and pressure such that the unsaturated carboxylic acid product is separated and recovered.
    Type: Application
    Filed: December 20, 2017
    Publication date: September 24, 2020
    Inventors: Robert GALLEN, Michael William Marshall TUCK
  • Patent number: 10785161
    Abstract: A method is provided by which a network adapter device receives a packet sent over a network from a peer, the packet including an enqueue timestamp indicating when the packet has been enqueued at the network adapter device. The network adapter device parses a header of the packet to detect whether the header includes bits indicating that the peer device is experiencing congestion, and obtains packet metadata of the packet and the enqueue timestamp of the packet. The network adapter device compares the packet metadata with information in a flow table to identify an entry in the flow table corresponding to a flow to which the packet metadata matches. The network adapter device sets a timer associated with the flow, the timer for use in scheduling transmission of a next packet provided by the host to be sent to the peer.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: September 22, 2020
    Assignee: CISCO TECHNOLOGY, INC.
    Inventors: Sagar Borikar, John William Marshall
  • Publication number: 20200296049
    Abstract: A method is provided by which a network adapter device receives a packet sent over a network from a peer, the packet including an enqueue timestamp indicating when the packet has been enqueued at the network adapter device. The network adapter device parses a header of the packet to detect whether the header includes bits indicating that the peer device is experiencing congestion, and obtains packet metadata of the packet and the enqueue timestamp of the packet. The network adapter device compares the packet metadata with information in a flow table to identify an entry in the flow table corresponding to a flow to which the packet metadata matches. The network adapter device sets a timer associated with the flow, the timer for use in scheduling transmission of a next packet provided by the host to be sent to the peer.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventors: Sagar Borikar, John William Marshall
  • Patent number: 10765695
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: September 8, 2020
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Publication number: 20200270607
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
    Type: Application
    Filed: February 5, 2020
    Publication date: August 27, 2020
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Publication number: 20200222165
    Abstract: A repair prosthetic for repairing a hernia is disclosed. In some embodiments, the repair prosthetic includes a patch body, a frame that assists in spreading the patch body from a reduced configuration to an expanded configuration, and a plurality of tethers attached to the patch body at locations between the frame and a periphery of the patch body. In various embodiments, the tethers can be tensioned to mitigate curling or creasing in the patch body to flatten the patch to facilitate attachment to tissue.
    Type: Application
    Filed: March 25, 2020
    Publication date: July 16, 2020
    Applicant: C.R. Bard, Inc.
    Inventors: Jonathan Bruce Trexler, Augustus Felix, Tami L. Rathbun, Cameron Michael Correia, Tyler William Marshall
  • Publication number: 20200216377
    Abstract: The present invention is directed to a process for the purification of ethylene glycol from a crude stream thereof.
    Type: Application
    Filed: June 26, 2018
    Publication date: July 9, 2020
    Inventors: Simon JACKSON, Adam Armour SNAITH, Michael William Marshall TUCK, David John WATSON, Michael Anthony WOOD
  • Patent number: 10696968
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: June 30, 2020
    Assignee: THERMO FISHER SCIENTIFIC INC.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Publication number: 20200123550
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for LDHA.
    Type: Application
    Filed: November 11, 2019
    Publication date: April 23, 2020
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Patent number: 10624729
    Abstract: A repair prosthetic for repairing a hernia is disclosed. In some embodiments, the repair prosthetic includes a patch body, a frame that assists in spreading the patch body from a reduced configuration to an expanded configuration, and a plurality of tethers attached to the patch body at locations between the frame and a periphery of the patch body. In various embodiments, the tethers can be tensioned to mitigate curling or creasing in the patch body to flatten the patch to facilitate attachment to tissue.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: April 21, 2020
    Assignee: C.R. Bard, Inc.
    Inventors: Tami L. Rathbun, Tyler William Marshall, Jonathan Bruce Trexler, Augustus Felix, Cameron Michael Correia