Patents by Inventor William Marshall

William Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of glycolic acid
    Patent number: 10087131
    Abstract: A process for the production of glycolic acid or derivatives thereof from formaldehyde comprising reacting formaldehyde with carbon monoxide and water in the presence of a silica catalyst, wherein from about 200 to about 5000 ppm of an alkyl silyl sulfonic acid is supplied to the reaction.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 2, 2018
    Assignee: Johnson Matthey Davy Technologies Limited
    Inventors: Simon Wayne Jackson, Adam Armour Snaith, Michael William Marshall Tuck, David John Watson
  • Methods and Compositions for Selecting siRNA of Improved Functionality
    Publication number: 20180214474
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
    Type: Application
    Filed: November 27, 2017
    Publication date: August 2, 2018
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Methods and Compositions for Selecting siRNA of Improved Functionality
    Publication number: 20180201934
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
    Type: Application
    Filed: January 4, 2018
    Publication date: July 19, 2018
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Methods and compositions for selecting siRNA of improved functionality
    Patent number: 10011836
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for F12.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: July 3, 2018
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
    Publication number: 20180119144
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
    Type: Application
    Filed: September 15, 2017
    Publication date: May 3, 2018
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • CARBONYLATION PROCESS AND CATALYST SYSTEM THEREFOR
    Publication number: 20180104673
    Abstract: A catalyst system for a liquid phase carbonylation reaction comprising a homogeneous acid catalyst component and a porous solid component, in particular for use in the formation of glycolic acid by carbonylation of formaldehyde. The homogeneous acid catalyst component is, for instance, sulphuric acid whilst the solid component can be unfunctionalised silica. A process for the carbonylation of an aldehyde to form a carboxylic? acid or derivative thereof is also described. The process comprises the steps of contacting the catalyst with carbon monoxide, water and the aldehyde.
    Type: Application
    Filed: March 24, 2016
    Publication date: April 19, 2018
    Inventors: Simon Wayne JACKSON, Adam Armour SNAITH, Michael William Marshall TUCK, David John WATSON
  • PROCESS FOR THE PRODUCTION OF GLYCOLIC ACID
    Publication number: 20180086686
    Abstract: A process for the production of glycolic acid or derivatives thereof from formaldehyde comprising reacting formaldehyde with carbon monoxide and water in the presence of a silica catalyst, wherein from about 200 to about 5000 ppm of an alkyl silyl sulfonic acid is supplied to the reaction.
    Type: Application
    Filed: March 23, 2016
    Publication date: March 29, 2018
    Inventors: Simon Wayne JACKSON, Adam Armour SNAITH, Michael William Marshall TUCK, David John WATSON
  • Methods and compositions for selecting siRNA of improved functionality
    Patent number: 9879266
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: January 30, 2018
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Tread with ultra efficient vulcanization system
    Patent number: 9846954
    Abstract: Tire treads having improved traction properties while surprisingly still maintaining good material cohesion properties, the tire treads comprising a rubber composition based upon a highly unsaturated diene elastomer and between 95 phr and 160 phr of an inorganic reinforcing filler. The composition may further include between 60 phr and 130 phr of a plasticizing system made up of a plasticizing resin having a Tg of at least 25° C. and a plasticizing liquid. The rubber composition is cured with an ultra-efficient sulfur curing system having a sulfur to accelerator weight ratio adjusted between 0.02 and 0.2 to provide the rubber composition with an MA300/G* ratio of greater than 1.7, wherein the elongation modulus MA300 at 300% is measured at 23° C. and the shear modulus G* is measured at 60° C.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 19, 2017
    Assignee: Compagnie Generale des Etablissements Michelin
    Inventors: Ramond Stubblefiled, Xavier Saintigny, William Marshall Thompson, Elizabeth L Holaling
  • Methods and compositions for selecting siRNA of improved functionality
    Patent number: 9839649
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: December 12, 2017
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Methods and Compositions for Selecting siRNA of Improved Functionality
    Publication number: 20170349904
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for F12.
    Type: Application
    Filed: August 16, 2017
    Publication date: December 7, 2017
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Methods and compositions for selecting siRNA of improved functionality
    Patent number: 9777270
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: October 3, 2017
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • RNAi targeting ZNF205
    Patent number: 9771586
    Abstract: Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for ZNF205.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: September 26, 2017
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • RNAi targeting SEC61G
    Patent number: 9719094
    Abstract: Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for SEC61G.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: August 1, 2017
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • RNAi targeting CNTD2
    Patent number: 9719092
    Abstract: Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for CNTD2.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: August 1, 2017
    Assignee: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • RNAi Targeting CNTD2
    Publication number: 20160369278
    Abstract: Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for CNTD2.
    Type: Application
    Filed: September 2, 2016
    Publication date: December 22, 2016
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • RNAi Targeting SEC61G
    Publication number: 20160369284
    Abstract: Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for SEC61G.
    Type: Application
    Filed: September 2, 2016
    Publication date: December 22, 2016
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • RNAi Targeting ZNF205
    Publication number: 20160369276
    Abstract: Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for ZNF205.
    Type: Application
    Filed: September 1, 2016
    Publication date: December 22, 2016
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • Doppler effect processing in a neural network model
    Patent number: 9449272
    Abstract: A method of frequency discrimination associated with the Doppler effect is presented. The method includes mapping a first signal to a first plurality of frequency bins and a second signal to a second plurality of frequency bins. The first signal and the second signal corresponding to different times. The method also includes firing a first plurality of neurons based on contents of the first plurality of frequency bins and firing a second plurality of neurons based on contents of the second plurality of frequency bins.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: September 20, 2016
    Assignee: QUALCOMM INCORPORATED
    Inventors: Robert William Marshall, Somdeb Majumdar
  • Methods and Compositions for Selecting siRNA of Improved Functionality
    Publication number: 20160201065
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
    Type: Application
    Filed: November 10, 2015
    Publication date: July 14, 2016
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe