Abstract: The present invention relates to inhibiting the activity of non-genotype 1 hepatitis C virus (HCV) NS3-NS4A protease activity. More particularly, the invention relates to inhibiting the activity of the protease from HCV genotype-2 or HCV genotype-3. The methods of the invention emply inhibitors that act by interfering with the life cycle of the HCV and are also useful as antiviral agents. The invention further relates to compositions comprising such compounds either for ex vivo use or for administration to a patient suffering from genotype-2 or genotype-3 HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.

Abstract: A mechanism for assigning unique addresses to identical devices attached to a serial bus is presented. Each device has at least one output and is provided with a storage device to provide a configurable portion of a bus address having a fixed portion and a configurable portion. The device is further provided with circuitry, coupled to the storage device and the output, to determine a state of the output and use the state to configure the configurable portion. Once the configurable portion is configured, the bus address uniquely identifies the device. Such configuration allows more than one such device to be coupled to the same serial bus, e.g., an I2C bus.

Abstract: A magnetic field sensor includes a diagnostic circuit that allows a self-test of most of or all of, the circuitry of the magnetic field sensor, including a self-test of a magnetic field sensing element used within the magnetic field sensor. The magnetic field sensor can generate a diagnostic magnetic field to which the magnetic field sensor is responsive.

Abstract: Methods for providing an integrated circuit using a multi-stage molding process to protect wirebonds. In one embodiment, a method includes attaching a die to a leadframe having a lead finger, attaching a wirebond between the die and the leadfinger, applying a first mold material over at least a portion of the wirebond and the die and the leadfinger to form an assembly, waiting for the first mold material to at least partially cure, and applying a second mold material over the assembly.

Abstract: A magnetoresistive (MR) sensing device includes MR elements electrically connected to form a bridge circuit and one or more non-functional (or “dummy”) MR elements for improved matching of the bridge circuit MR elements.

Abstract: A magnetoresistive (MR) sensing device includes MR elements electrically connected to form a bridge circuit and one or more non-functional (or “dummy”) MR elements for improved matching of the bridge circuit MR elements.

Abstract: A magnetic field has a threshold that adapts in relation to a magnitude of a magnetic field signal representative of a movement of an object. A corresponding method adapts a threshold in relation to a magnitude of a magnetic field signal representative of a movement of an object.

Abstract: An electronic circuit for sensing a current includes a circuit board having first and second major opposing surfaces and a current conductor for carrying the current. The current conductor includes a circuit trace disposed upon the circuit board. The electronic circuit also includes an integrated circuit disposed upon and electrically coupled to the circuit board at a position so as to straddle the current conductor.

Abstract: Methods and apparatus for providing an integrated circuit using a multi-stage molding process to protect wirebonds. In one embodiment, a method includes attaching a die to a leadframe having a lead finger, attaching a wirebond between the die and the leadfinger, applying a first mold material over at least a portion of the wirebond and the die and the leadfinger to form an assembly, waiting for the first mold material to at least partially cure, and applying a second mold material over the assembly.

Abstract: An integrated circuit can have a first substrate supporting a magnetic field sensing element and a second substrate supporting another magnetic field sensing element. The first and second substrates can be arranged in a variety of configurations. Another integrated circuit can have a first magnetic field sensing element and second different magnetic field sensing element disposed on surfaces thereof.

Abstract: A magnetoresistive (MR) sensing device includes MR elements electrically connected to form a bridge circuit and one or more non-functional (or “dummy”) MR elements for improved matching of the bridge circuit MR elements.

Abstract: The invention describes a method for assaying HCV NS3 protease activity using an NS3•4A protease molecule. The invention also provides a method for screening and identifying modulators of NS3 protease.

Abstract: A magnetic field sensor includes built in self-test circuits that allow a self-test of most of, or all of, the circuitry of the magnetic field sensor, including self-test of a magnetic field sensing element used within the magnetic field sensor, while the magnetic field sensor is functioning in normal operation.

Abstract: A material stack has an electrical resistance generally the same in the presence of a magnetic field and in the presence of no magnetic field. The electrical resistance of the material stack has a temperature coefficient generally the same as a magnetoresistance element.

Abstract: An integrated circuit can have a first substrate supporting a magnetic field sensing element and a second substrate supporting another magnetic field sensing element. The first and second substrates can be arranged in a variety of configurations. Another integrated circuit can have a first magnetic field sensing element and second different magnetic field sensing element disposed on surfaces thereof.

Abstract: A sensor that includes a magnetic flux concentrator is presented. The sensor includes a sensor integrated circuit with a structure that includes a magnetic field sensor to sense a magnetic field generated by an external magnetic flux source comprising a magnetic article. The stricture has a first surface to face the external magnetic flux source and an opposing second surface. The sensor integrated circuit also includes a lead frame connected to the structure and having a base portion with a first base portion surface to support the stricture and an opposing second base portion surface. Also provided in the sensor is a magnetic flux concentrator to concentrate magnetic flux of the magnetic field.

Abstract: A sensor responsive to movement of a detection target includes a magnetic field transducer operative to provide a magnetic field signal proportional to a magnetic field associated with the detection target, a peak detector for tracking positive and negative peaks of the magnetic field signal to generate a tracking signal, and a comparator having a first input responsive to the magnetic field signal, a second input responsive to an input signal related to the tracking signal, and an output at which is provided an output signal comprising first pulses having a first pulse width when the detection target moves in a first direction and second pulses having a second pulse width when the detection target moves in a second direction.

Abstract: A portable apparatus and method for demonstrating different characteristics of different fluids that includes different fluid sumps or chambers for receiving samples of the different fluids. A test shaft having different portions that are immersed in the different fluid samples in the chambers is driven by an electric drive motor at a substantially constant speed while substantially the same amount of friction or force is applied to the different portions of the test shaft at different times to increase the resistance presented to the drive motor. The additional amount of current drawn or power absorbed by the motor or strain induced in the motor drive shaft during the application of such friction or force to the different portions of the test shaft is monitored and compared to provide a comparison of the friction or power loss characteristics of the different fluid samples.

Abstract: Magnetic field sensors and associated methods of manufacturing the magnetic field sensors include molded structures to encapsulate a magnetic field sensing element and an associated die attach pad of a lead frame and to also encapsulate or form a magnet or a flux concentrator.

Abstract: An integrated circuit comprises a plurality of layers including a first substrate with an on chip capacitor and a second substrate. In one embodiment, the second substrate has an on chip capacitor. The first and/or second substrate can include a sensor element, such as a magnetic sensor element.