Abstract: A system for predicting tire lift-off propensity of a vehicle tire includes a vehicle tire-affixed tire-identification device for providing a tire-specific identification, multiple tire-affixed sensors mounted to the tire measuring tire-specific parameters and generating tire-specific parameter information, one or more vehicle-affixed sensor(s) mounted to the vehicle to measure vehicle speed and a lift-off propensity estimator generating a lift-off propensity for the vehicle tire from a database containing experimentally-derived, tire-ID specific, lift-off propensities correlated with measured tire-specific parameter information and vehicle speeds.

Abstract: A non-transitory computer readable medium having computer executable instructions stored thereon is provided. The computer executable instructions include a mission definition file (MDF) that includes mission data that describes alternative routes generated by at least one mission planner for a vehicle. An MDF parser extracts the mission data for the alternative routes from the MDF and maps the mission data into a temporal data structure describing the alternative routes. The temporal data includes a route list to describe the alternative routes for the vehicle and a route segment list to describe an estimated time between each of the waypoints for each segment of the route list. A waypoint list describes a latitude, a longitude, and an altitude for each of the waypoints and a mission plan constructor generates a network topology of a mission plan depicting the alternative routes for the vehicle over time.

Abstract: An assembly determines operating parameters of a tire. The assembly includes a tripod sensor mounted within an inner cavity of the tire underneath a crown portion and an innerliner on which the tripod sensor is mounted. The tripod sensor includes a tri-axial accelerometer for creating a circumferential signal for determining slip ratio, a lateral signal for determining a slip angle, and a radial signal for determining load on the tire.

Abstract: Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.

Abstract: An interface includes a human machine interface (HMI) to provide a visualization of current and future states of a mission associated with one or more unmanned vehicles. A time specifier provides input to the HMI to specify a current time or a future time for the visualization of the current and future states of the mission. A prediction engine generates predictions of the current and future states of the mission for the visualization based on the current time or the future time specified by the time specifier.

Abstract: A tire-based system and method for estimating a radially outward tire surface temperature of an identified tire supporting an identified vehicle includes a temperature sensor to measure a tire inner liner temperature. An algorithmic prediction model is empirically trained to correlate inner liner tire temperature to tire radially outward surface temperature for the tire/vehicle combination. The empirically trained algorithmic prediction model receives a steady state temperature-based model inputs including the tire inner liner temperature and an ambient temperature measurement and transient behavior vehicle-based inputs. Based upon the steady state inputs and the transient behavior inputs, a radially outward tire surface temperature estimation is made.

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Abstract: Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: A collapsible goal and shelter system is provided with a collapsible frame, a net, and a cover. The collapsible frame includes an erect configuration and a collapsed configuration. The net is operable to be attached to the frame, when the frame is in the erect configuration to thereby form a goal. The cover is operable to be attached to the frame, when the frame is in the erect configuration to thereby form a shelter.

Abstract: Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in ˜20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.

Abstract: A system for predicting tire lift-off propensity of a vehicle tire includes a vehicle tire-affixed tire-identification device for providing a tire-specific identification, multiple tire-affixed sensors mounted to the tire measuring tire-specific parameters and generating tire-specific parameter information, one or more vehicle-affixed sensor(s) mounted to the vehicle to measure vehicle speed and a lift-off propensity estimator generating a lift-off propensity for the vehicle tire from a database containing experimentally-derived, tire-ID specific, lift-off propensities correlated with measured tire-specific parameter information and vehicle speeds.

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Abstract: A system and method of estimating a load bearing on a vehicle tire includes an inflation pressure measuring sensor for measuring an inflation pressure level within a tire cavity; a contact patch length sensor measuring the rolling contact patch length of the tire; a tire rolling speed sensor measuring a rolling speed of the tire; and a tire wear state estimation calculator estimating a tire wear state of a tread of the tire. An artificial neural network estimates a tire load from the contact patch length, the inflation pressure level, and the tire rolling speed by utilizing as a compensation factor input the estimated tire wear state.

Abstract: The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.

Abstract: A tire wear state estimation system includes a tire pressure measuring device affixed to a vehicle tire for measuring tire inflation pressure and generating tire inflation pressure data; tire torsional mode measuring means for measuring tire torsional mode frequency and generating tire torsional mode frequency data; and tire identification means for generating tire-specific torsional mode coefficients using tire-specific identification data. A tire wear estimation is made based upon the tire inflation pressure data, the torsional mode frequency data, and the tire identification derived torsional mode coefficients.

Abstract: The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.

Abstract: Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively.

Abstract: A dynamic load estimation system and method is provided, the system including a tire supporting a vehicle; a vehicle-mounted acceleration sensor for determining a vehicle lateral acceleration and a vehicle longitudinal acceleration; a roll angle calculating model for determining a vehicle roll angle; a roll rate calculating model for determining a vehicle roll rate; a static normal load calculation model for calculating a measured static normal load; and a dynamic tire load estimation model for calculating an estimated dynamic load on the tire from the measured static normal load, the vehicle roll angle, the vehicle roll rate, the vehicle lateral acceleration and the vehicle longitudinal acceleration.

Abstract: A tire-based system and method for estimating a radially outward tire surface temperature of an identified tire supporting an identified vehicle includes a temperature sensor to measure a tire inner liner temperature. An algorithmic prediction model is empirically trained to correlate inner liner tire temperature to tire radially outward surface temperature for the tire/vehicle combination. The empirically trained algorithmic prediction model receives a steady state temperature-based model inputs including the tire inner liner temperature and an ambient temperature measurement and transient behavior vehicle-based inputs. Based upon the steady state inputs and the transient behavior inputs, a radially outward tire surface temperature estimation is made.