Abstract: The pyrazoles and pyrazolopyrimidines of the formula 1

Abstract: An accessory for releasably securing to a ladder. The accessory has at least one stabilizing arm for stabilizing and supporting the ladder when leaned against a building or structure. The stabilizing arm has a generally U-shaped configuration with a pair of generally parallel leg members that are spaced apart by a distance approximating the distance between the centers of adjacent ladder rungs. Each of the leg members ends in a ladder rung engaging member having a fore and an aft end, and is receivable within the hollow interior of a ladder rung. The ladder rung engaging members are oriented in a convergent configuration such that inserting them the hollow interiors of a pair of ladder rungs causes the fore and aft ends of the ladder rung engaging members to bind against opposite sides of the interior surfaces of the ladder rungs, and to releasably secure the stabilizing arm to the ladder.

Abstract: The pyrazoles and pyzazolopyrimidines of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined herein, have corticotropin releasing factor (CRF) antagonist activity. As such, they are effective in the treatment of a wide range of diseases including stress-related illnesses.

Abstract: A filter cartridge that includes a track etched membrane sealed therein in a leak-free manner, and a method for making the cartridge. The filter cartridge has a bubble point that is at least 50% of the bubble point of the track etched membrane. In one embodiment, the method includes disposing the track etched membrane below a heat source and orienting the membrane so that it melts back on itself, and then allowing the membrane to cool to form a leak-free seal.

Abstract: A pick box (1) of a tooling system for mineral winning etc., has an elongated aperture (4) to receive, in use, a removable liner sleeve (6) of the tooling system, the box (1) providing a seating surface (7) extending orthogonally with respect to the axis (5) of the aperture (4). The external periphery of the sleeve (6) and the internal periphery (8) of the box aperture (4) are so profiled, e.g. hexagonally, as to prevent relative rotation and the internal periphery of the box aperture is interrupted at (11) to provide at least one surface for engagement, in use, with a retainer device (12) of an inserted sleeve (6), whilst the sleeve has an external groove (22) to receive a retainer device (12). The invention also includes a sleeve (6) having an enlarged head (16), a longitudinal circular bore (26), and a circumferential groove (22) fitted with a retainer ring (12). The invention further includes a box (1) and a sleeve (6) in combination, and a drum (3).

Abstract: The pyrazoles and pyzazolopyrimidines of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined herein, have corticotropin releasing factor (CRF) antagonist activity. As such, they are effective In the treatment of a wide range of diseases including stress-related illnesses.

Abstract: Using a variable stiffness guidewire to cross a stenosed region of a patient's vasculature by advancing the distal end of the guidewire to the stenosed region, reducing the flexibility of the distal end of the guidewire, and further advancing the distal end through and past the stenosed region of the lumen. The variable stiffness guidewire has a longitudinally movable core member with a proximal end and a shapable distal end, a compressible body is slidably mounted on the core member, with one end of the compressible body secured to the end of the core member, and a tubular support member is disposed about the core member with a distal end that abuts the proximal end of the compressible body. The guidewire further comprises a tensioning means at the proximal end to move the core member longitudinally with respect to the tubular support member so as to compress and reduce the flexibility of the compressible body.

Abstract: A filter cartridge that includes a track etched membrane sealed therein in a leak-free manner, and a method for making the cartridge. The filter cartridge has a bubble point that is at least 50% of the bubble point of the track etched membrane. In one embodiment, the method includes disposing the track etched membrane below a heat source and orienting the membrane so that it melts back on itself, and then allowing the membrane to cool to form a leak-free seal.

Abstract: A copier apparatus and method includes a scanning station for electronically scanning a set of document sheets to be copied as a copy job. The scanning station includes a platen or glass for supporting a document sheet scanned in a first mode wherein the document sheet is manually positioned on the platen by an operator and the scanning station operates in a second mode wherein document sheets are automatically fed to the station by a feeder. An operator control panel includes a display for indicating options for selection by an operator. These options include selection for scanning of a document sheet from the set in the first mode or the second mode. Another option available allows the operator to identify that all document sheets of the set are scanned for this copy job. A controller is responsive to signals generated pursuant to selections for actuating the scanning station to scan document sheets from the set in the first and second modes.

Abstract: A system assures smooth motion in a distributed virtual reality environment y categorizing the information to be transmitted as to the predictability of future motion and applying appropriate smoothing algorithms based upon knowledge of what the future motion is likely to be. The system switches between a linear interpolation algorithm for less predictable data and a Catmull-Rom spline for more predictable data.

Abstract: A hydraulic circuit includes a fluid pressure inlet line (1); a fluid pressure delivery line (2); and a filter unit (FU) interposed between the inlet line (1) and the delivery line (2), with the circuit incorporating an automatic back flushing facility. The latter comprises a valve arrangement A, B, C, D, capable of temporarily preventing initial flow of fluid through the filter unit (FU) in a delivery direction, causing reverse fluid flow through the filter unit (FU) in a back flushing direction, for a predetermined period, with the flushing sequence initiated by the valve arrangement sensing a flow of fluid, at a predetermined pressure, and after the predetermined period, causing fluid flow in the normal delivery direction.

Abstract: An acoustic displacement flowmeter determines the flow rate of a fluid in a path containing a controllable valve by establishing fluid flow along the path, directing the flow of the fluid to a transducer having a displacement element by restricting the flow path, generating a signal from the transducer representative of displacement due to fluid flow while the flow path is restricted, using the transducer to determine the fluid flow rate, and reestablishing fluid flow along the path by removing the restriction. The transducer signal is used to determine the fluid flow rate by providing an analog reference signal, integrating the analog reference signal for a predetermined time period, deintegrating the integrated reference signal with the transducer signal until the value of the deintegration signal reaches a threshold value, and using the time required for the deintegration signal to reach the threshold value to calculate the flow rate.

Abstract: The pyrazoles and pyzazolopyrimidines of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined herein, have corticotropin releasing factor (CRF) antagonist activity. As such, they are effective in the treatment of a wide range of diseases including stress-related illnesses.

Abstract: A water cooling apparatus utilizes a conventional ice maker to produce ice which is deposited into a large insulated storage tank. The insulated storage tank includes a suspended grate to hold the deposited ice and spray nozzles positioned above the grate bathe the ice with water. Upon spraying, the ice suspended in the tank partially melts, combines with, and cools the sprayed water. A reservoir in the bottom of the tank collects the cooled water, and a sump pump in the bottom of the reservoir pumps water out of the storage tank to a distribution pump. The cooled water is further distributed under pressure to the fogging nozzles positioned in the enclosure's ventilation system. Sensors monitor the level of ice on the grate, the level of cooled water in the reservoir, and the temperature of the animal enclosure.

Abstract: A chair (10) having adjustable height includes a seat (11) and a number of leg members (12). An adjusting mechanism (30) includes an insert sleeve (40) received within a hollow area (31) of a leg member (12). The insert sleeve (40) has an internal thread (52) which threadably receives a leg extension (60) having an external thread (61). Rotation of the leg extension (60) within the sleeve (40) adjusts the length of the leg member (12).

Abstract: The technical field of the invention generally concerns electronic mail systems. The present invention provides an ATM or POS system having a terminal (22, 24, 26, 28 or 34) and processor (18 or 36) which are connected to an ATM or POS data communications network. The network also includes a store and forward message switch (52) which stores user messages for remote retrieval and use as an electronic mail system (10) on a data communications network (42). Messages can be stored or retrieved through standard ATM or POS terminals, through a service bureau, through touch tone telephones (84) or via modems (76). Messages can be retrieved remotely and sent to a facsimile machine (82), a remote paging device, computer (72) or the like. Message information may include payment of user bills, completion of user financial transactions and transmission of information from a variety of databases. Such message information may be generated and transmitted by the system at times predetermined by the user.

Abstract: The technical field of the disclosure generally concerns electronic mail systems. The present invention provides an ATM or POS system having a terminal and process or which are connected to an ATM or POS data communications network. The network also includes a store and forward message switch which stores user messages for remote retrieval and use as an electronic mail system on a data communications network. Messages can be stored or retrieved through standard ATM or POS terminals, through a service bureau, through touch tone telephones or via modems. Messages can be retrieved remotely and sent to a facsimile machine, a remote paging device, computer or the like.