Abstract: The present invention provides a compound of Formula I: wherein R is H or R1 is H, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C2-C3 alkenyl, OCF3, R2 is H, halogen, C1-C3 alkyl, C1-C3 alkoxy, or C2-C4 alkenyl; R3 is NH2, or CH2NH2; and X is O, OCH2, OCH2CH2, OCH(CH3), CH2O, SCH2, CH2S, CH2, NHCH2, CH2NH, N(CH3)CH2, CH2CH2, C?C, or a bond, wherein X is connected to phenyl ring A at the ortho or the meta position, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis and rheumatoid arthritis.

Abstract: Systems and methods for collaborative chat messaging are provided herein. In an example, a system having a non-transitory computer-readable medium, a communications interface, and a processor is provided. The processor may execute instructions to establish a virtual meeting having a plurality of participants, each participant of the plurality of participants exchanging one or more audio streams via the virtual meeting. The processor may also execute instructions to transmit a collaborative message request to the plurality of participants, receive one or more collaborative message responses from each participant of a subset of the plurality of participants, and provide, to a first client device, the one or more collaborative message responses. The processor may also execute instructions to receive, from the first client device, an indication to release the one or more collaborative message responses and transmit, to the plurality of participants, the one or more collaborative message responses.

Abstract: A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.

Abstract: A filter base for receiving a complementary mating filter housing assembly. The filter base includes a base platform having fluid ingress and egress stanchions, and a wire harness assembly including a connector housing integral with or connected to the base platform for establishing an electrical connection between the filter base and the filter housing assembly. The wire harness assembly includes conductors extending between first and second connectors, with one or more resilient contacts provided on the second connector. The connector housing has an upper surface and an oppositely facing lower surface and is dimensioned to receive a first end portion of the one or more contacts. The contacts are flexible from a first position to a second position when a mating portion of the one or more contacts engages a mating connection surface of the filter housing assembly.

Abstract: A software platform supports multiple carriers, such as telephony carriers or public switched telephone network (PSTN) carriers, and routes calls between devices associated with different carriers without having to route the calls through the different carriers. The software platform establishes or maintains the calls between the devices associated with different carriers by transmitting a portion of call data associated with call record information to the respective carriers, and a portion of the call data associated with media and signaling information to the destination device.

Abstract: Described herein are systems, devices, methods, and media for transmitting emergency alerts, emergency services requests, and emergency data associated with emergency alerts and emergency service requests to relevant parties, such monitoring centers and emergency service providers.

Abstract: Disclosed are examples of a system, techniques and non-transitory computer-readable storage medium that enable the selection of a response document template for generating an appropriate response to notification document. Respective components may generate an electronic document from the notification document. A common theme between two or more of the electronic documents may be identified. The electronic documents identified as having the common theme may be grouped in a notification document corpus. The notification document corpus may be analyzed with reference to received notification documents stored in a document repository. Based on results of the analysis, a template of a notification response document appropriate for responding to a specific notification document received by the enterprise may be selected. The selected response document template may be forwarded to a client device for further processing.

Abstract: A supply control system for a tank utilized in a semiconductor manufacturing process is disclosed.

Abstract: Described herein are systems, devices, methods, and media for connecting a user for providing emergency assistance based on emergency alerts from triggering devices such as voice or sound triggered emergency alerts. In some cases, the location of the emergency is provided.

Abstract: An augmented reality-based lighting design method includes displaying, by an augmented reality device, a real-time image of a target physical area on a display screen. The method further includes displaying, by the augmented reality device, a lighting fixture 3-D model on the display screen in response to a user input, where the lighting fixture 3-D model is overlaid on the real-time image of the target physical area. The method also includes displaying, by the augmented reality device, a lighting pattern on the display screen overlaid on the real-time image of the target physical area, wherein the lighting pattern is generated based on at least photometric data associated with the lighting fixture 3-D model.

Abstract: A device for dispensing a liquid may include a basin defining a reservoir, a pump including a barrel and a spring, the barrel coupled to the basin, the barrel defining a cavity, and the spring disposed in the cavity, and an actuator at least partially disposed in the reservoir, the actuator defining a first orifice, a second orifice, and a lumen extending between the first orifice and the second orifice, the reservoir in fluid communication with the lumen via the first orifice, the actuator depressible to move the second orifice in a first direction defined from the reservoir toward the cavity of the barrel, and the spring of the pump biasing the actuator to move in a second direction defined from the cavity of the barrel toward the reservoir.

Abstract: A panel system provides a prefabricated exterior building façade. Various wall claddings and clips for hanging wall claddings are discussed. Panel connector parts are disclosed for hanging wall cladding panels against a building wall. Panel connector parts are disclosed for hanging dual layers of insulating material against a building wall with a drainage cavity or gap defined between the dual layers. A wall cladding system includes: a building wall; a plurality of wall cladding panels each comprising insulating material and defining an external face, a rear face, and side edges, with adjacent of the wall cladding panels abutting one another along respective side edges; panel connector parts mounted on the building wall and mounting the plurality of wall cladding panels as a continuous thermal break layer against the building wall.

Abstract: After loss of communications between a cash handling device and a financial institution, transactions may continue to be processed. In one configuration, the transactions may be processed up to a predefined transaction limit. Transaction limits may be defined by a number of transactions, a dollar amount transacted or to be transacted, an amount of time and/or combinations thereof. Additionally or alternatively, the transaction limit may be specific to one or more types of transactions. Transaction data may be stored in memory until communication has been re-established, at which time the data may be transmitted to the financial institution for processing.

Abstract: An illuminable display assembly including (a) a housing having a base securable to a support surface, a platform detachably mounted to the base, and a generally enclosed interior bounded from above by the platform. The platform includes a plurality of illuminable windows spaced apart from each other therealong. The display assembly further includes (b) a plurality of retractable tethers mounted to the platform in the interior of the housing. The tethers fasten corresponding display containers to the platform and urge the display containers to predetermined positions adjacent corresponding windows. The display assembly further includes (c) a lighting system including one or more interior light sources in the interior of the housing for illuminating the windows and display containers from below.

Abstract: A washing machine appliance and methods of operating a washing machine appliance are provided. The washing machine appliance includes a motor and a rotatable basket. The motor is operated to rotate the basket to a first speed. The basket is then decelerated from the first speed to a second speed less than the first speed. A deceleration time is determined while decelerating the basket from the first speed to the second speed. The method may include, or the washing machine appliance may be configured for, determining a size of a load of articles in the basket of the washing machine appliance based on the deceleration time. Based on the determined size of the load, one or more operating parameters of the washing machine appliance are selected and an operation of the washing machine appliance is performed according to the one or more selected operating parameters.

Abstract: Described herein are methods of sanitizing and preserving produce and other agricultural products, for example for consumption as Ready-to-Eat. The methods can comprise treating the products with a sanitizing agent and forming a protective coating over the products.

Abstract: A computing system retrieves ball-by-ball data for a plurality of sporting events. The computing system generates a trained neural network based on ball-by-ball data supplemented with ball-by-ball data with ball-by-ball match context features and personalized embeddings based on a batsman and a bowler for each delivery. The computing system receives a target batsman and a target bowler for a pitch to be delivered in a target event. The computing system identifies target ball-by-ball data for a window of pitches preceding the to be delivered pitch. The computing system retrieves historical ball-by-ball data for each of the target batsman and the target bowler. The computing system generates personalized embeddings for both the target batsman and the target bowler based on the historical ball-by-ball data. The computing system predicts a shot type for the pitch to be delivered based on the target ball-by-ball data and the personalized embeddings.

Abstract: Disclosed are systems and methods for a vehicle and projector module. The vehicle can include a compartment. The vehicle can include a projector module configured to extend from the compartment to provide light to a projector screen.

Abstract: A collapsible firearm butt-stock assembly has a shoulder stock 18 coupled with a pair of guide rods 20, 22 slideable in respective guide holes 14, 16 of a housing 12. A locking mechanism including locking members engageable with guide rod recesses 26, 28 provided in the guide rods has an actuator 30 that is movable in the lengthways direction of the guide rods to release the locking members to allow sliding movement of the shoulder stock relative to the housing.

Abstract: A device may provision two or more servers, each of the servers including a network interface. In addition, the device may enable the network interface in each of the provisioned servers, create a shared volume, assign the shared volume to each of the provisioned servers, and enable a clustering application on each of the provisioned servers to form a cluster comprising the provisioned servers, the cluster having a heartbeat via the network interfaces.