Abstract: The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from carboplatin, gemcitabine, cisplatin, 5-fluorouracil, cyclophosphamide, etoposide, vincristine, doxorubicin and irinotecan. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.

Abstract: The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from carboplatin, gemcitabine, cisplatin, 5-fluorouracil, cyclophosphamide, etoposide, vincristine, doxorubicin and irinotecan. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.

Abstract: The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor.

Abstract: Apparatus for making circuitized substrates using a continuous roll format in which layers of conductor and dielectric are fed into the apparatus, bonded, and passed on to other nearby work stations in which various processes such as hole formation, circuitization and, finally, segmentation occur. The resulting substrates can then be individually bonded to other, like substrates to form a larger multi-layered substrate with a plurality of conductive thru-holes, conductive and dielectric layers as part thereof.

Abstract: The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor

Abstract: The present invention provides a simplified set of characteristics that can be used to select 1,2,4 benzotriazine 1,4 dioxide compounds (TPZ analogues) with therapeutic activity against hypoxic cells in human tumour xenografts, and to further provide a novel class of 1,2,4-benzotriazine-1,4-dioxides (TPZ analogues) with predicted in vivo activity against tumours, to their preparation, and to their use as hypoxia-selective cytotoxic drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Abstract: The present invention relates to DNA-targeted 1,2,4-benzotriazine-1,4-dioxides and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Abstract: A circuit for spread spectrum rate control uses a first interpolator to phase interpolate between a first signal and a second signal and generate a first output signal based on a first control signal. A second interpolator is utilized to phase interpolate between a third signal and a fourth signal and generate a second output signal based on a second control signal. A multiplexer is used to select, based on a select signal, the first output signal or the second output signal as a spread spectrum clock (SSCLK). A leap-frog interpolator control is used to generate, in synchronism with the SSCLK, the first control signal based on a first type of phase adjustment request, the second control signal based on a second type of phase adjustment request, and the select signal to switch the multiplexer between the first output signal and the second output signal after allowing for an interpolator settling time when changing the first control signal or the second control signal.

Abstract: A method of making a circuitized substrate and an electrical assembly utilizing same in which the substrate is comprised of at least two sub-composites in which the dielectric material of at least one of these sub-composites is heated during bonding (e.g., lamination) to the other sufficiently to cause the dielectric material to flow into and substantially fill openings in a conductive layer for the bonded structure. Conductive thru-holes are formed within the bonded structure to couple selected ones of the structure's conductive layers. Formation of an electrical assembly is possible by positioning one or more electrical components (e.g., semiconductor chips or chip carriers) on the final structure and electrically coupling these to the structure's external circuitry.

Abstract: The present invention provides one or more books of holograms recorded in a recording medium, wherein two or more short stacks of the one or more books have locations that differ from each other by a movement difference. The present invention also provides methods and devices for recording and reading holograms from the one or more books of holograms.

Abstract: A novel hybrid maize variety designated X5M895 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X5M895 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X5M895 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize hybrid_variety X5M895, the hybrid seed, the hybrid plant produced from the seed, and variants, mutants, and minor modifications of hybrid maize variety X5M895. This invention further relates to methods for producing maize varieties derived from hybrid maize variety X5M895 and to the maize varieties derived by the use of those methods.

Abstract: A sample chamber includes a movable upper chamber. The movable upper chamber includes a center bore opening to a bottom of the chamber, at least one port for introduction of gas under pressure to the center bore, and a first annular seal around the center bore. A stationary lower seat opposing the upper chamber has a center bore aligned with the upper chamber, and includes an exhaust and a second annular seal around the center bore. A test material is placed between the upper chamber and the lower seat. An actuator moves the upper chamber. When the upper chamber is moved down with the first annular seal in contact with an upper surface of a sample of the material and the second annular seal in contact with a lower surface of the sample, gas introduced to the upper chamber goes through the upper chamber and out through the exhaust.

Abstract: A novel inbred maize line designated PHCAM and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHCAM with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PHCAM through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the inbred line PHCAM or a trait conversion of PHCAM with another maize line. Inbred maize lines derived from inbred maize line PHCAM, methods for producing other inbred maize lines derived from inbred maize line PHCAM and the inbred maize lines and their parts derived by the use of those methods.

Abstract: An apparatus for acquiring and holding liquid samples and methods using the same.

Abstract: The present invention relates to synergistic combinations of the compound 5,6 -dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from carboplatin, gemcitabine, cisplatin, 5-fluorouracil, cyclophosphamide, etoposide, vincristine, doxorubicin and irinotecan. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.

Abstract: This invention provides compounds defined by Formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of treating osteo- and rheumatoid arthritis.

Abstract: In order to reduce the area of a charge pump PLL, one may separate proportional component and integral component of the loop filter voltage, and add additional circuitry so as to make the integral component appear as though it is affected by a much larger value of capacitance than is actually used. In an aspect, a current mirror may be used to subtract a portion of the integral component of the loop filter voltage from the total loop filter voltage. The difference signal is then used to drive an oscillator in the charge pump PLL. In another aspect, a third integrator or auto-calibration loop is used to set a center frequency of the oscillator.

Abstract: Recovery apparatus for recovering radio frequency tags from solid support devices in the form of cans (2) which include such tags and also resin on which chemical compounds are synthesized includes a stack of cans (2) which are fed into the apparatus wherein they are received within a port (28) of a rotating disc (26). The disc rotates to a position adjacent to a magnet 32 and blade (34). In this position, the magnet attracts the radio frequency device so that it is raised upwardly towards the lid end of the can, whereafter the blade (34) is able to slice through the lower end of the can to open it, whereupon the solid support resin falls out of the can into a receptacle (36). The disc continues to move until the remains of the can are over a receptacle (40), whereupon the magnetic force is released so the tag falls into receptacle (40) from which it may be retrieved, for re-use.

Abstract: The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.

Abstract: A semiconductor laser device, with a semiconductor laser element operable to oscillate and output a laser beam, is provided with a heat generation unit operable to generate heat so as to regulate the temperature of the semiconductor laser element, a laser beam splitting unit operable to split a laser beam, oscillated and output from the semiconductor laser element, into first and second beams each forming an optical path different from each other, and a heat generation control unit operable to control the amount of heat generated by the heat generation unit so as to maintain constant a fringe spacing between interference fringes with a plurality of fringes obtained as a result of the interference between the first and second beams.