Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, and/or inflammatory diseases, for example multiple sclerosis and psoriasis.

Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis, rheumatoid arthritis and psoriasis.

Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.

Abstract: Provided herein are solid state forms of Vemurafenib hydrochloride, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising said solid state forms.

Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, and/or inflammatory diseases, for example multiple sclerosis and psoriasis.

Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, or inflammatory diseases, for example multiple sclerosis and psoriasis.

Abstract: Provided herein are solid state forms of Vemurafenib hydrochloride, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising said solid state forms.

Abstract: The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.

Abstract: The invention relates to a step switch, comprising a preselector and a fine selector. The invention is characterized in that the step switch has a connection (36) between the pre-selector and the fine selector (18), at least one coupling switch (38) being arranged in said connection. A pre-selector can be switched in a largely gas-free manner by means of said switchable connection with the aid of the fine selector.

Abstract: The invention relates to a switching arrangement (15) with a pre-selector (28) for a power transformer (10, 40) which has multiple windings (12, 14). The pre-selector is designed to optionally connect at least one first winding (12) to one of the two end contacts (30, 32) of at least one second winding (14). At least one first switch is arranged in the connection between the preselector (28) and the first winding (12), thereby allowing the pre-selector to be switched in an arc-free manner and thus in a gas-free manner as well.

Abstract: The invention relates to an on-load tap changer for step transformers, which has one main current branch and one auxiliary current branch for each of the two winding taps to be switched. In each main current branch and auxiliary current branch, switching is accomplished by means of a vacuum switching tube. According to the invention, an additional mechanical contact is provided in each of the main current branches and in each of the auxiliary current branches between the respective winding tap to which said branch is electrically connected and the respective vacuum switching tube in said branch. Said mechanical contacts are switched in such a way that the vacuum switching tubes in the main current branch and the auxiliary current branch of the unconnected winding tap can be galvanically isolated from the unconnected winding tap.

Abstract: Dolutegravir potassium salt and solid state forms thereof are provided, as well as methods of making and interconverting these forms. The Dolutegravir potassium forms, and pharmaceutical compositions containing them, may be used to treat subjects in need of medical treatment, such as for HIV infection.

Abstract: The present invention relates to a composition comprising tapentadol in a dissolved form and oral dosage forms comprising said composition. The invention further relates to a process for producing the composition comprising tapentadol in a dissolved form and to the corresponding process of producing an oral dosage form containing the composition of the invention. Finally, the invention relates to the use of a saturated tapentadol solution for the preparation of a solid oral dosage form.

Abstract: The invention relates to substantially pure Desfesoterodine salts, Desfesoterodine salts, solid state forms thereof and pharmaceutical compositions comprising one or more of the Desfesoterodine salts and/or solid state forms thereof.

Abstract: The invention relates to a tap changer having vacuum interrupters for switching over between winding taps of a tapped transformer without interruption. The tap changer according to the invention having vacuum interrupters is based on the general idea of combining the functionalities of at least one conventional vacuum switching contact which switches under load and a further mechanical switching means according to the prior art in just one single vacuum interrupter with two separately moving contact systems.

Abstract: The present invention provides Vemurafenib salts, particularly Vemurafenib esylate and Vemurafenib choline, and solid state forms thereof and processes for preparing these compounds. The present invention also provides the use of the solid state forms of Vemurafenib and of the Vemurafenib salts for preparing Vemurafenib or other Vemurafenib salts, and solid state forms thereof.

Abstract: An on-load tap changer for uninterrupted changeover between winding taps of a tapped transformer has a separate selector for power-free preselection of the winding tap to be switched to, a separate load changeover switch for the actual load changeover from the previous to the preselected new winding tap, a rotatable drive shaft, and a force accumulator with at least one force-accumulator spring that for each load changeover is initially stressed by the drive shaft and after triggering thereof abruptly actuates the load changeover switch. A gear operatively connected with the drive shaft can load the force accumulator. A first mechanical freewheel between the gear and the force accumulator temporarily decouples the force accumulator from rotation with the drive shaft in such a manner that the force accumulator can be stressed with a delay in time after the start of actuation of the drive shaft.

Abstract: Provided herein are solid state forms of Vemurafenib hydrochloride, processes for preparing the solid state forms, as well as pharmaceutical compositions and formulations comprising said solid state forms.

Abstract: The present invention relates to Vemurafenib choline salt, solid state forms thereof, processes for preparation thereof and formulations thereof. The present invention also relates to the use of the solid state forms of Vemurafenib choline salt for preparing Vemurafenib or other Vemurafenib salts, and solid state forms thereof.

Abstract: The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.