Abstract: Crystalline forms of Afatinib di-maleate are described in the present application and processes for their preparation. The present invention also includes pharmaceutical compositions of such crystalline forms of Afatinib di-maleate, methods of their preparation and the use thereof hi the treatment of a patient in need thereof. The present invention also describes preparing Afatinib free base and salts of Afatinib, other than Afatibin di-maleate, and solid forms thereof.

Abstract: The present invention relates to Vemurafenib choline salt, solid state forms thereof, processes for preparation thereof and formulations thereof. The present invention also relates to the use of the solid state forms of Vemurafenib choline salt for preparing Vemurafenib or other Vemurafenib salts, and solid state forms thereof.

Abstract: The invention relates to substantially pure Desfesoterodine salts, Desfesoterodine salts, solid state forms thereof and pharmaceutical compositions comprising one or more of the Desfesoterodine salts and/or solid state forms thereof.

Abstract: Afatinib salts and crystalline forms thereof are described in the present application and processes for their preparation. Crystalline forms of Afatinib are also described in the present application and processes for their preparation. The present invention also includes pharmaceutical compositions of such Afatinib salts and crystalline forms thereof or crystalline forms of Afatinib, methods of their preparation and the use thereof in the treatment of a patient in need thereof.

Abstract: The invention relates to a tap changer for the interruption-free switchover between winding taps of a tap-changing transformer. Furthermore, the present invention relates to a novel vacuum interrupter which is particularly suitable for such a tap changer. The tap changer according to the invention is based on the general concept of combining in each case one main contact (V1) and one mechanical switching means (U1), connected in series therewith, of a first load branch and an additional resistive contact (V3) of a second load branch in only a single vacuum interrupter (1) with a common housing (5).

Abstract: The present invention relates to a load transfer switch for a tap changer, comprising permanent main contacts that switch powerlessly for each phase. The general inventive concept lies in connecting the fixed permanent main contacts of side A or B of the load transfer switch by means of a movable rail-shaped permanent main contact that establishes an electrical connection to the corresponding permanent main contacts of the load line only in the end positions of the movable rail-shaped permanent main contact and in addition only provides for a single deflection for actuation, which connects in a purely compressive manner the plurality of contact fins of the corresponding fixed permanent main contact, which contact fins are connected in a resilient, articulated manner.

Abstract: The invention relates to a tap changer for the interruption-free switchover between winding taps of a tap-changing transformer. Furthermore, the present invention relates to a novel vacuum interrupter which is particularly suitable for such a tap changer. The tap changer according to the invention is based on the general concept of combining in each case one main contact (V1) and one mechanical switching means (U1), connected in series therewith, of a first load branch and an additional resistive contact (V3) of a second load branch in only a single vacuum interrupter (1) with a common housing (5).

Abstract: Afatinib salts and crystalline forms thereof are described in the present application and processes for their preparation. Crystalline forms of Afatinib are also described in the present application and processes for their preparation. The present invention also includes pharmaceutical compositions of such Afatinib salts and crystalline forms thereof or crystalline forms of Afatinib, methods of their preparation and the use thereof in the treatment of a patient in need thereof.

Abstract: The present invention relates to compounds of the formula I wherein R1, R2, R3, R4, X and Y have the meanings given in the description. The compounds have an action which is immunomodulating and inhibits or regulates the release of IL-1? and/or TNF-?. They can therefore be used for treatment of diseases connected with a disturbance in the immune system.

Abstract: The invention relates to an on-load tap changer for switching between winding taps of a step transformer without interruption, comprising a separate selector for preselecting the winding tap to be switched to without control current, and a separate load transfer switch for actually transferring the load from the previous to the preselected new winding tap. The invention further relates to an energy store having at least one energy store spring that is first tensioned for each load transfer by a rotating drive shaft and that abruptly actuates the load transfer switch after being triggered. According to the invention, a gear is provided by means of which the energy store can be tensioned after mechanical freewheel is provided between the gear and the energy store, such that the energy store can be tensioned after a time delay, and a further mechanical freewheel (17) is provided between the energy store and a step-by-step motion linkage actuating the load transfer switch.

Abstract: The present invention relates to the choline and tromethamine salt of Licofelone.

Abstract: The present invention relates to a load transfer switch for a tap changer, comprising permanent main contacts that switch powerlessly for each phase. The general inventive concept lies in connecting the fixed permanent main contacts of side A or B of the load transfer switch by means of a movable rail-shaped permanent main contact that establishes an electrical connection to the corresponding permanent main contacts of the load line only in the end positions of the movable rail-shaped permanent main contact and in addition only provides for a single deflection for actuation, which connects in a purely compressive manner the plurality of contact fins of the corresponding fixed permanent main contact, which contact fins are connected in a resilient, articulated manner.

Abstract: The invention relates to solid tapentadol in non-crystalline form together with a surface stabiliser in the form of a stable intermediate. In the intermediate of the invention, tapentadol is preferably present in amorphous form or in the form of a solid solution. The invention further relates to methods of producing tapentadol in a solid, non-crystalline form and to pharmaceutical formulations containing solid, non-crystalline tapentadol.

Abstract: The invention relates to a polyimide microparticles which can be obtained by means of the following steps: a) a polymer solution consisting of at least one polyimide polymer and a solvent or a solvent mixture is produced according to methods known per se, b) microparticles are formed from the polymer solution by spraying or by thermal phase inversion, c) the microparticles obtained in step b) are treated with an aqueous functionalization solution containing an amine-containing modifier at a high temperature, with or without stirring, and d) the modified obtained are washed and optionally dried, according to methods known per se.

Abstract: The invention relates to an on-load tap changer for step transformers, which has one main current branch and one auxiliary current branch for each of the two winding taps to be switched. In each main current branch and auxiliary current branch, switching is accomplished by means of a vacuum switching tube. According to the invention, an additional mechanical contact is provided in each of the main current branches and in each of the auxiliary current branches between the respective winding tap to which said branch is electrically connected and the respective vacuum switching tube in said branch. Said mechanical contacts are switched in such a way that the vacuum switching tubes in the main current branch and the auxiliary current branch of the unconnected winding tap can be galvanically isolated from the unconnected winding tap.

Abstract: The present invention relates to compounds of the formula I wherein R1, R2, R3, R4, X and Y have the meanings given in the description. The compounds have an action which is immunomodulating and inhibits or regulates the release of IL-1? and/or TNF-?. They can therefore be used for treatment of diseases connected with a disturbance in the immune system.

Abstract: The invention relates to an on-load tap changer having an energy storage mechanism for changing over, without any interruptions, between different winding taps of a tap-changing transformer on load. According to the invention, the energy storage mechanism has one or more compression springs, which are tensioned at the beginning of a changeover operation. In comparison with the tensile springs used to date with such energy storage mechanisms, the compression springs have markedly greater long-term strength.

Abstract: The present invention relates to the choline and tromethamine salt of Licofelone.

Abstract: The present invention relates to a new crystalline modification of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,S-dihydro-1H-pyrrolizin-S-ylacetic acid which is referred to as polymorph B. It has a peak in the solid state 13C-NMR spectrum (with adamantane as external reference standard; CH group d=29.45 ppm) in the range from 179.8 to 180.2 ppm and can be processed directly to a pharmaceutical formulation.

Abstract: The abstract relates to an arrangement of an oil-filled power transformer having an oil-filled stepping switch, wherein only a single oil expansion vessel is provided, this oil expansion vessel being connected both to the oil volume of the stepping switch and also to the transformer tank, which is likewise oil-filled, via corresponding flanges.