Abstract: The present invention generally relates to antibodies that bind to CD3 and CD19, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: An apparatus for decoding a sequence of pictures from a data stream is configured for decoding a picture of the sequence by: deriving a residual transform signal of the picture from the data stream; combining the residual transform signal with a buffered transform signal of a previous picture of the sequence so as to obtain a transform signal of the picture, the transform signal representing the picture in spectral components; and subjecting the transform signal to a spectral-to-spatial transformation, wherein the buffered transform signal comprises a selection out of spectral components representing the previous picture.

Abstract: The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: The present invention relates to glycosylation patterns at the Fab portion of a monoclonal antibody and methods for the regulation during culture of a microorganism expressing a monoclonal antibody with regulated content of high mannose Fab glycoforms.

Abstract: An ion-jet electron-entangled pathogens analyzer imprinted on a test strip resembles the functionality of a scanning tunneling microscope as a hand-held device, to quickly detect pathogens in water and food products on their bioelectrical signature. The use of such a device does not require special training or preparation. The test strip consists of an integrated circuit which gets energized and communicates over a weak alternating electric field provided by a matchbox-sized base station, which also contains a trained machine learning module of bioelectrical pathogen signatures. The base station connects wirelessly to smart devices or networks for further processing or recording the measurement results in a blockchain. The base station can be worn as a smartwatch or attached to processing machines, transportation vehicles, warehouses, shelves and grocery stores.

Abstract: Described herein are Mpro cysteine protease inhibitors and methods of utilizing such inhibitors in the treatment of diseases, disorders, or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: The present invention generally relates to antibodies that bind to CD3 and CD19, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.

Abstract: Described herein are Mpro cysteine protease inhibitors and methods of utilizing such inhibitors in the treatment of diseases, disorders, or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: Disclosed is a system for interacting with polyisoprene based products to enhance sensing features. The system includes a hub unit and one or more electronic circuitries operably configured with the polyisoprene based product. The hub unit includes a controller for contactless powering and communicating data with the polyisoprene based product, a generator for generating a frequency, a resonator for increasing voltage level of the frequency, a first electrode for emitting the alternating electric field, a second electrode for receiving the alternating electric field from the polyisoprene based product, an analog digital converter connected to the second electrode to digitize information received from the polyisoprene based product under the influence of the alternating electric field. The one or more electronic circuitries senses the condition of the polyisoprene based product and communicates further to the hub unit for processing and communicating processed information over a communication network.

Abstract: The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.

Abstract: Disclosed is a SmartDust system for contactless digital controlled serialized analog processing of analog values received from an object. The SmartDust system includes a hub unit and at least one electronic circuitry capacitive coupled to the hub unit. The hub unit includes an oscillator for generating a frequency, and a first electrode connected to the oscillator to emit the frequency as an alternating electric field. The electronic circuitry stores and performs switching instructions and the digital logic operations. The electronic circuitry receives analog values and generate sampled and processed analog values. The electronic circuitry provides the processed values to external components. The hub unit includes a controller for providing the switching instructions and the digital logic operations to the electronic circuitry, and a modulator for modulating the alternating electric field with the switching instructions and the digital logic operations.

Abstract: The present invention generally relates to antibodies that bind to CD3, including multi specific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: Disclosed is a system for monitoring parts in a machine is provided. The system includes a base unit, and an electronic circuitry. The base unit includes a generator for generating controllable frequency, an impedance unit to resonate impedance with a matching frequency, a controller for modulating the impedance with commands, a first electrode to emit an alternating electric field, a mixer, and a communication unit for communicating the data and commands over a communication network. Further, the controller decodes changes in the impedance.

Abstract: Disclosed is a method and a system for stimulating and communicating with floral objects. The system includes a base unit for communicating with the floral objects to read and stimulating physical and biological properties, and an electronic circuitry configured to be placed in reach of the floral objects. The electronic circuitry is capacitively coupled to the base unit and the floral objects. The base unit is able to create and communicate stimulated patterns to stimulate growth, biological properties of the floral object. The base unit generates stimulated pattern on receiving information and data from the electronic circuitry.

Abstract: The techniques described herein relate to methods, apparatus, and computer readable media for content-aware image storage. A set of images is accessed from a storage device, each image of the set of images containing at least a part of a screenshot of a display of a computing device used by a user. The set of images is sorted using a similarity metric to obtain a sorted set of images. The sorted set of images are encoded using a video codec to obtain a video encoding the sorted set of images. The video is stored in conjunction with metadata indicating a correspondence between images in the set of images and frames in the video.

Abstract: The present invention refers to NPY Y1 receptor-targeting peptide moieties, and their use for the target-specific treatment of cancers and other diseases.

Abstract: Disclosed is a system for protecting electronic devices from counterfeiting and misuse. The system includes a hub unit and a smart switch. The hub unit includes a generator, a modulator and a first conductive surface. The smart switch is connected to sub-circuits and capacitively coupled to the hub unit. The smart switch includes a transmission gate, a second conductive surface, a rectifier, a buffer, a demodulator, and a latch. The smart switch receives switching instructions over an alternating electric field from the hub unit to operate the electronic device.