Abstract: Provided are a live broadcast message display method and apparatus. The method comprises: when it is detected that a time interval between the current time and the time when a live broadcast message is last acquired is equal to a target message acquisition interval, sending a present message acquisition request to a server, and receiving live broadcast messages returned by the server and an updated target message acquisition interval; determining a message rolling rate according to the updated target message acquisition interval and the number of live broadcast messages returned by the server; and according to the determined message rolling rate, displaying the live broadcast messages in a rolling manner in a display area.

Abstract: A radio frequency system package may include waveguides and loading blocks. The loading blocks may include dielectric material having a high dielectric constant between 13 and 20. Additionally, the loading blocks may be made of mold, epoxy, or the like material, and the loading blocks may fit into a region cut out of the waveguides. Moreover, the loading blocks may lower the cut-off frequency for wireless communication otherwise provided by the waveguides without the loading blocks (e.g., 28 GHz). In particular, the loading blocks may facilitate communication in low mmWave frequencies, such as 24 GHz.

Abstract: A tracking attachment for an oral care implement that includes a housing and a tracking unit configured to track position, orientation, or movement of the oral care implement. The housing may define a receiving cavity that is configured to receive a portion of the oral care implement. The housing may include a first housing portion having an inner surface that defines a first portion of the receiving cavity that is open at both of the first and second ends of the first housing portion and a second housing portion that mates with the first housing portion to detachably couple the second housing portion to the first housing portion. The second housing portion may have an inner surface that defines a second portion of the receiving cavity that is open at the second end of the second housing portion.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: An approach is provided in which the approach loads a machine learning model and a set of test case statistical data into a user system. The set of test case statistical data is based on a set of test cases corresponding to the machine learning model and includes a plurality of input parameter sets and a corresponding set of output quality measurements. The approach compares user data on the user system against the set of test case statistical data and identifies one of the plurality of input parameter sets to optimize the machine learning model based on the set of output quality measurements. The approach generates an optimized machine learning model using the machine learning model and the identified input parameter set at the user system.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or ?-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Abstract: An oral care system that includes an oral care implement and a tracking attachment. The oral care implement may include a handle and a head. The tracking attachment is detachably coupled to the oral care implement. The tracking attachment may include a housing including a first housing portion having an inner surface that defines a first cavity and a second housing portion having an inner surface that defines a second cavity. The tracking attachment may also include a tracking unit configured to facilitate tracking at least one of a position, orientation, or movement of the oral care implement to which it is attached. A first portion of the handle may be positioned within the first cavity and a second portion of the handle may be positioned within the second cavity.

Abstract: Example implementations relate to heat-sink chambers. For instance, in an example a heat-sink can include a body including a first surface and a second surface, where the body defines: a chamber that extends from the first surface through a portion of a total thickness of the body; an opening in the second surface; and a channel that extends from the chamber through a remaining portion of the total thickness of the body to the opening to couple the chamber to the opening.

Abstract: The present invention relates to the technical field of gene engineering and particularly relates to a method for constructing non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield, recombinant strain constructed by method, and application of recombinant strain. According to the present invention, a diacylglycerol acyltransferase gene (DGAT) is overexpressed in Mucor circinelloides WJ11 by a homologous recombination technology, and exogenous oil is added for fermentation, such that the non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield is constructed. Compared with the control strain Mc2075, the fat yield of the Mucor circinelloides is increased; and when the diacylglycerol acyltransferase (DGAT) is transformed into the uracil defective type of Mucor circinelloides WJ11, the fatty acid composition changes after fermentation, and the lipid content may reach 53% of dry cell weight after the fermentation condition is optimized.

Abstract: The present disclosure relates to a construction method of a Mucor circinelloides cell factory for producing dihomo-?-linolenic acid and a fermentation technology, belonging to the field of genetic engineering. In the present disclosure, ?-linolenic acid elongase gene glelo is obtained from Mortierella alpine by cloning, the gene is ligated to an integrative plasmid pMAT1552, and transformed into a Mucor circinelloides defective strain Mu402, and the gene glelo is integrated into Mucor circinelloides genome through homologous recombination, to obtain the recombinant strain Mc-glelo, and finally, the expression of the gene glelo in Mucor circinelloides is realized. The lipid content in the recombinant strain Mc-glelo is not obviously different from that in the control strain Mc1552, however, the lipid composition changes greatly, and dihomo-?-linolenic acid appears in the lipids of the recombinant strain Mc-glelo, and the content thereof reaches 5.7% of the total fatty acids.

Abstract: The present application discloses a dicarboxylic acid transporter and its encoding gene dit gene for increasing oil yield of Mucor circinelloides, the dit gene is cloned from the high-yield M. circinelloides WJ11, and the dit gene is transformed into M. circinelloides deficient strain Mu402, the dit gene is integrated into the genome of M. circinelloides by homologous recombination to obtain recombinant strain Mc-Dit. The total fatty acid content of the Mc-Dit strain increased by 33.76% and the intracellular lipid content may reach up to 17.67% of the dry biomass.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or ?-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Abstract: A radio frequency identification gasket for sealing a bottle mouth has an adhesive layer, an aluminum-plastic film layer, a radio frequency identification layer and a composite film functional layer from bottom to top, wherein the composite film functional layer is formed with a reserved structural weakening zone therein, the radio frequency identification layer is set with a structure of a radio frequency identification antenna line that is destroyed when the composite film functional layer is torn. The composite film functional layer forms the reserved structural weakening zone therein through physical treatment, and the physical treatment is one of die micro-pressing, laser micro-cutting or electron beam micro-cutting. The radio frequency identification gasket is mounted in the bottle mouth and has the functions of sealing and reading and writing radio frequency tags, and also has an anti-counterfeiting effect.

Abstract: Examples of a chassis component are described herein. In an example, the chassis component can have a recess having a mesh structure and a working fluid disposed therein. A conductive cover can seal the recess with the mesh structure and the working fluid therein.

Abstract: Examples of devices and methods for controlling speed of cooling elements are discussed. The device comprises a first temperature reader to measure an ambient temperature in the vicinity of the device. The device further comprises a processor to control a speed of a cooling element of the device based on a comparison of the ambient temperature with a first threshold temperature.

Abstract: The present invention relates to the technical field of gene engineering and particularly relates to a method for constructing non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield, recombinant strain constructed by method, and application of recombinant strain. According to the present invention, a diacylglycerol acyltransferase gene (DGAT) is overexpressed in Mucor circinelloides WJ11 by a homologous recombination technology, and exogenous oil is added for fermentation, such that the non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield is constructed. Compared with the control strain Mc2075, the fat yield of the Mucor circinelloides is increased; and when the diacylglycerol acyltransferase (DGAT) is transformed into the uracil defective type of Mucor circinelloides WJ11, the fatty acid composition changes after fermentation, and the lipid content may reach 53% of dry cell weight after the fermentation condition is optimized.

Abstract: A C4-dicarboxylic acid transporter and its encoding gene C4mt gene can increase oil yield of Mucor circinelloides, the C4mt gene may be cloned from the high-yield M. circinelloides WJ11, and the C4mt gene is transformed into M. circinelloides deficient strain Mu402, the C4mt gene can be integrated into the genome of M. circinelloides by homologous recombination to obtain recombinant strain Mu-C4mt. The total fatty acid content of the Mu-C4mt strain can be increased by 25.30% and the intracellular lipid content may reach up to 16.34% of the dry biomass.

Abstract: Provided is construction of Mucor circinelloides cell factory for producing stearidonic acid (SDA) and fermentation technology. ?15 Desaturase gene is obtained by cloning from Mortierella alpina, the gene is ligated to an integrative plasmid pMAT1552, and transformed into a Mucor circinelloides defective strain Mu402, and ?15 Desaturase gene is integrated on Mucor circinelloides genome through homologous recombination, to obtain the recombinant strain Mc-?15, finally, the expression of the ?15 Desaturase gene in Mucor circinelloides is realized. The recombinant new strain is accession number CGMCC No. 15888, and the classification name is Mucor circinelloides-D15D.