Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present invention provides compounds of Formula (1): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: A high bandwidth radiation-resistant multimode optical fiber includes a core and a cladding layer surrounding the core. The core is a fluorine-doped quartz glass layer with a graded refractive index distribution and a distribution power exponent ? of 1.7-2.2. The core has R1 of 15-35 ?m and ?1%min of ?0.8% to ?1.2%. The cladding layer has an inner cladding layer having R2 of 15-38 ?m and ?2% of ?0.8% to ?1.2% and/or a depressed inner cladding layer having R3 of 15-55 ?m and ?3 of ?1.0% to ?1.4%, an intermediate cladding layer having R4 of 15.5-58 ?m and ?4 of ?0.7% to ?0.2% a depressed cladding layer hasving R5 of 16-60 ?m and ?5 of ?0.8% to ?1.2%, and an outer cladding layer sequentially formed from inside to outside. The outer cladding layer is a pure silica glass layer.

Abstract: An anti-cracking panda-type polarization-maintaining optical fiber includes a cladding layer, stress layers, and a fiber core. The fiber core is located in the center of the cladding layer. The stress layers are located symmetrically at two sides of the fiber core with a distance away from the fiber core and are located within the cladding layer. Each stress layer is enclosed at edges of their outer sides by a transition layer with a gradient refractive index. By providing the transition layer with the gradient refractive index at the edge of the outer side of the stress layer, the pressure stress at the edge of the stress layer is decomposed and released, so as to avoid cracks at the edge of the polished stress layer on the end of the optical fiber, and thus optimizes the performance of the polarization-maintaining optical fiber by decreasing the room temperature polishing cracking rate.

Abstract: A driving route matching method, apparatus, and storage medium. The method includes: obtaining a route to be retrieved, the route including a retrieval start point and a retrieval end point; performing a search in a database of existing routes, and selecting the existing routes passing through grids within a predetermined range around the start point as routes available for the start point; performing a search in the database of the existing routes, and selecting the existing routes passing through grids within a predetermined range around the search endpoint as routes available for the end point; calculating intersections of the routes available for the start point and the routes available for the end point, and using the routes in the intersections as candidate routes; and screening the candidate routes according to detouring distances. The driving route matching method and apparatus enable a remarkable improvement in the efficiency of driving route matching.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Abstract: Disclosed is a line card chassis which includes line card units, optical electrical conversion units and optical fiber interface units. The optical-electrical conversion unit has an onboard optical assembly module used for mutual conversion between an optical signal and an electrical signal; an electrical signal interface of the onboard optical assembly module is connected to the line card unit through an electrical connector, and an optical signal interface of the onboard optical assembly module is connected to the optical fiber interface unit through an optical connector; and the optical fiber interface unit couples the optical signal to a cluster interface of a panel on a router through an optical fiber, and the cluster interface is to concatenate different chassis in the router. Also disclosed is a multi-chassis cluster router and a packet processing method.

Abstract: Systems and methods are directed to a task management platform for managing autonomous vehicles. In one example, a computer-implemented method for managing a fleet of vehicles includes obtaining, by a computing system comprising one or more computing devices, vehicle state data indicative of vehicle state from one or more vehicles among a fleet of vehicles. The method further includes determining, by the computing system, if a vehicle event has occurred based at least in part on the vehicle state data. The method further includes in response to determining a vehicle event has occurred, generating, by the computing system, one or more tasks for resolution of the vehicle event, wherein the one or more tasks include data associated with the one or more vehicles and the vehicle event. The method further includes providing, by the computing system, data associated with the one or more tasks to a remote operator computing system.

Abstract: Systems and methods for managing a fleet of vehicles are provided. In one example embodiment, a computer-implemented method includes obtaining data representing vehicle state information associated with one or more vehicles among a fleet of vehicles at one or more times. The method includes predicting a future vehicle state associated with the one or more vehicles at one or more future times. The method includes scheduling a vehicle assignment in a predetermined set of vehicle assignments for a selected vehicle among the one or more vehicles before a first future time among the one or more future times. The method includes transmitting a command signal to a computing system associated with the selected vehicle based at least in part on the scheduled vehicle assignment.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or ?-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: Embodiments of the present disclosure relate to adaptive RFID communication. A tag device includes a storage configured to store content that is executable by a proxy device associated with a reader device. The tag device includes a communication component configured to transmit the content to the reader device, the content, when executed by the proxy device, causing an action associated with the tag device to be performed.

Abstract: The present invention provides compounds of Formula (I): P-Ma??(I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: An encryption method includes: converting a section of express information into a binary sequence, grouping the binary sequence into a plurality of group data, and aligning each group data into an information matrix; converting the information matrix into a corresponding a basic group information matrix; randomly choosing a reference DNA sequence from a gene library, and aligning the reference DNA sequence into a basic group transition matrix, using the basic group transition matrix to convert the basic group information matrix into an encrypted information matrix, and exploding the encrypted information matrix to obtain a basic group information sequence; generating a primer for the basic group information sequence, and adding the primer before and behind the primer generator to obtain a completed DNA sequence; and synthesizing a DNA matter based on the completed DNA sequence.

Abstract: A heat dissipation module adapted for an electronic device is provided. The heat dissipation module includes a heat dissipation structure and a heat dissipation fan. The heat dissipation structure is disposed in a casing of the electronic device and has a heat dissipation portion and an extending portion, wherein the extending portion has a slot, and a heat dissipation flow channel is formed between the heat dissipation portion and the casing. The heat dissipation fan is detachably assembled to the extending portion to be adjacent to the heat dissipation portion, wherein the heat dissipation fan covers the slot, the slot is connected to the heat dissipation flow channel, the heat dissipation fan is adapted to provide a heat dissipation air flow, and a part of the heat dissipation air flow passes through the slot and the heat dissipation flow channel in sequence.

Abstract: The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Abstract: Disclosed is a line card frame. The line card frame internally comprises a line card unit, a switching unit, and an optical fiber interface unit. The switching unit internally comprises a switching chip module and an onboard optical component module, the onboard optical component module being used for realizing mutual conversion of an optical signal and an electrical signal; an electrical signal interface of the onboard optical component module is connected to the switching chip module having an exchange routing function, and the switching chip module is connected to the line card unit by means of an electric connector; an optical signal interface of the onboard optical component module is connected to the optical fiber interface unit by means of an optical connector; and the optical fiber interface unit connects the optical signal to a cluster interface on a router panel by means of an optical fiber, and the cluster interface is used for realizing the cascading between different frames of a router.