Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present application discloses a dicarboxylic acid transporter and its encoding gene dit gene for increasing oil yield of Mucor circinelloides, the dit gene is cloned from the high-yield M. circinelloides WJ11, and the dit gene is transformed into M. circinelloides deficient strain Mu402, the dit gene is integrated into the genome of M. circinelloides by homologous recombination to obtain recombinant strain Mc-Dit. The total fatty acid content of the Mc-Dit strain increased by 33.76% and the intracellular lipid content may reach up to 17.67% of the dry biomass.

Abstract: A ring-peel-seal liner is revealed, the ring-peel-seal liner includes a metal sealing layer and an adhesive layer. The metal sealing layer has a first annular tear line, and is defined into an annular region and a central region by the first annular tear line, wherein the annular region encircles the central region. The adhesive layer is adhered on one surface of the metal sealing layer. With the ring-peel-seal liner described above, the issue of needing an additional liner for enhancing a sealing effect after opening a conventional packaging container is resolved.

Abstract: The present disclosure provides a natural plant preparation, including extracts of the following parts of plants: roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus, drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., Walnut and Vaccinium Spp, cloves of Allium sativum, and petals of Rosa sp. The present disclosure further provides a method for preparing a plant preparation, including treating the above parts of plants with ethanol.

Abstract: The present invention provides compounds of Formula (1): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present disclosure relates to a construction method of a Mucor circinelloides cell factory for producing dihomo-?-linolenic acid and a fermentation technology, belonging to the field of genetic engineering. In the present disclosure, ?-linolenic acid elongase gene glelo is obtained from Mortierella alpine by cloning, the gene is ligated to an integrative plasmid pMAT1552, and transformed into a Mucor circinelloides defective strain Mu402, and the gene glelo is integrated into Mucor circinelloides genome through homologous recombination, to obtain the recombinant strain Mc-glelo, and finally, the expression of the gene glelo in Mucor circinelloides is realized. The lipid content in the recombinant strain Mc-glelo is not obviously different from that in the control strain Mc1552, however, the lipid composition changes greatly, and dihomo-?-linolenic acid appears in the lipids of the recombinant strain Mc-glelo, and the content thereof reaches 5.7% of the total fatty acids.

Abstract: Provided is construction of Mucor circinelloides cell factory for producing stearidonic acid SDA and fermentation technology thereof. ?15 Des gene is obtained by cloning from Mortierella alpina, the gene is ligated to an integrative plasmid pMAT1552, and transformed into a Mucor circinelloides defective strain Mu402, and ?15 Des is integrated on Mucor circinelloides genome through homologous recombination, to obtain the recombinant strain Mc-?15, finally, the expression of the ?15 Des gene in Mucor circinelloides is realized. The recombinant new strain was preserved in China General Microbiological Culture Collection Center on Jun. 20, 2018, and the address is NO. 1 West Beichen Road, Chaoyang District, Beijing. The center gave the biological material the preservation number CGMCC No. 15888, and the suggested classification name is Mucor circinelloides-D15D.

Abstract: The present disclosure provides a natural plant preparation, including extracts of the following parts of plants: roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus, drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., Walnut and Vaccinium Spp, cloves of Allium sativum, and petals of Rosa sp. The present disclosure further provides a method for preparing a plant preparation, including treating the above parts of plants with ethanol.

Abstract: An electronic device and a method for controlling a fan operation are provided. A containing space of the electronic device has a fan module and a deformation sensor. The deformation sensor detects whether a fan housing of the fan module is deformed. The deformation sensor transmits a deformation signal to a controller when detecting that the fan housing is deformed. The controller drives a fan blade of the fan module to stop running after receiving the deformation signal.

Abstract: A container seal includes an inner element and an outer element. The inner element has at least one through hole. The outer element is adhered to the inner element and is releasable from the inner element. The container seal is conducive to preventing a user from being stained with contents of a container covered with the container seal while tearing the container seal. The container seal can be pierced by a soft straw whereby the user sucks the contents of the container.

Abstract: Disclosed is a line card frame. The line card frame internally comprises a line card unit, a switching unit, and an optical fiber interface unit. The switching unit internally comprises a switching chip module and an onboard optical component module, the onboard optical component module being used for realizing mutual conversion of an optical signal and an electrical signal; an electrical signal interface of the onboard optical component module is connected to the switching chip module having an exchange routing function, and the switching chip module is connected to the line card unit by means of an electric connector; an optical signal interface of the onboard optical component module is connected to the optical fiber interface unit by means of an optical connector; and the optical fiber interface unit connects the optical signal to a cluster interface on a router panel by means of an optical fiber, and the cluster interface is used for realizing the cascading between different frames of a router.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Abstract: A high bandwidth radiation-resistant multimode optical fiber includes a core and a cladding layer surrounding the core. The core is a fluorine-doped quartz glass layer with a graded refractive index distribution and a distribution power exponent ? of 1.7-2.2. The core has R1 of 15-35 ?m and ?1%min of ?0.8% to ?1.2%. The cladding layer has an inner cladding layer having R2 of 15-38 ?m and ?2% of ?0.8% to ?1.2% and/or a depressed inner cladding layer having R3 of 15-55 ?m and ?3 of ?1.0% to ?1.4%, an intermediate cladding layer having R4 of 15.5-58 ?m and ?4 of ?0.7% to ?0.2% a depressed cladding layer hasving R5 of 16-60 ?m and ?5 of ?0.8% to ?1.2%, and an outer cladding layer sequentially formed from inside to outside. The outer cladding layer is a pure silica glass layer.

Abstract: An anti-cracking panda-type polarization-maintaining optical fiber includes a cladding layer, stress layers, and a fiber core. The fiber core is located in the center of the cladding layer. The stress layers are located symmetrically at two sides of the fiber core with a distance away from the fiber core and are located within the cladding layer. Each stress layer is enclosed at edges of their outer sides by a transition layer with a gradient refractive index. By providing the transition layer with the gradient refractive index at the edge of the outer side of the stress layer, the pressure stress at the edge of the stress layer is decomposed and released, so as to avoid cracks at the edge of the polished stress layer on the end of the optical fiber, and thus optimizes the performance of the polarization-maintaining optical fiber by decreasing the room temperature polishing cracking rate.

Abstract: Disclosed is a line card chassis which includes line card units, optical electrical conversion units and optical fiber interface units. The optical-electrical conversion unit has an onboard optical assembly module used for mutual conversion between an optical signal and an electrical signal; an electrical signal interface of the onboard optical assembly module is connected to the line card unit through an electrical connector, and an optical signal interface of the onboard optical assembly module is connected to the optical fiber interface unit through an optical connector; and the optical fiber interface unit couples the optical signal to a cluster interface of a panel on a router through an optical fiber, and the cluster interface is to concatenate different chassis in the router. Also disclosed is a multi-chassis cluster router and a packet processing method.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Abstract: A ring-peel-seal liner is revealed, the ring-peel-seal liner includes a metal sealing layer and an adhesive layer. The metal sealing layer has a first annular tear line, and is defined into an annular region and a central region by the first annular tear line, wherein the annular region encircles the central region. The adhesive layer is adhered on one surface of the metal sealing layer. With the ring-peel-seal liner described above, the issue of needing an additional liner for enhancing a sealing effect after opening a conventional packaging container is resolved.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.