Abstract: A system, a wearable device, and a method are provided which can increase the accuracy of physiological metrics while detecting if the patient ingested digital medicine and/or improve performance of the wearable device. The wearable device can comprise machine executable instructions that when executed by the processor, cause the processor to perform various algorithms, such as, for example, at least one of a step count algorithm, a body angle algorithm, a heart rate algorithm, a peak finder algorithm, an adaptive thresholding algorithm, a heart rate variability algorithm, a R-R cleaning Algorithm, a deltaR-R cleaning algorithm, a merge twin interval algorithm, a split tall intervals algorithm, an absorb short intervals algorithm, a bimodal detection algorithm, and a resting algorithm.

Abstract: Various implementations include hearing assist devices and systems for processing audio signals. In particular implementations, a process includes receiving an input signal via a microphone; performing a sound pressure level (SPL) shift that decreases a gain of the input signal to generate a gain reduced audio signal; amplifying the gain reduced audio signal using dynamic range compression to generate an amplified audio signal; generating a noise reduced amplified signal using active noise reduction that simultaneously processes the input signal; and outputting the noise reduced amplified signal to an electrodynamic transducer.

Abstract: A system may include an electronic device such as a head-mounted device and a handheld input device for controlling the electronic device. The handheld input device may include a stylus and a removable sleeve on the stylus. The input-output capabilities of the handheld input device may be shared between the stylus and the removable sleeve. The stylus may include touch sensor circuitry, a force-sensitive tip, and a motion sensor. The sleeve may include conductors for translating touch input on the sleeve to the touch sensor circuitry on the stylus, a deformable member for translating forces on the sleeve to the force-sensitive tip of the stylus, and visual markers that can be detected by an external camera and used with motion sensor data from the stylus to track the handheld input device. The removable sleeve may include haptic output devices and a battery and may be attached to an item without electronics.

Abstract: A method for autonomously routing data with reduced latencies over the Internet includes sending one or more ping messages from a first node to one or more genesis nodes on the Internet, receiving one of the ping messages from the first node by a first genesis node, sending a reply message to invite the first node to join a pulse group if the first node is selected based on predetermined criteria, automatically measuring one-way latencies between a plurality of nodes in the pulse group, wherein the pulse group includes the first genesis node, a first node, and a second node, automatically removing a node from the pulse group if fluctuations of one-way latencies associated with the node exceed a pre-determined threshold, and automatically determining a lower-latency data routing path from the first node to the second node based on the one-way latencies measured in the pulse group.

Abstract: An integrated circuit is provided that comprises a first thermal sink layer, a first ground plane associated with a first set of circuits that have a first operational temperature requirement, a first thermally conductive via that couples the first ground plane to the first thermal sink layer, a second thermal sink layer, a second ground plane associated with a second set of circuits that have a second operational temperature requirement that is higher than the first operational temperature requirement, and a second thermally conductive via that couples the second ground plane to the second thermal sink layer. The first thermal sink layer is cooled at a first temperature to maintain the first set of circuits at the first operational temperature requirement and the second thermal sink layer is cooled at a second temperature to maintain the second set of circuits at the second operational temperature requirement.

Abstract: At a display of a computer system, a user interface is displayed that includes a placement location configured to spatially accommodate a respective user interface object of a plurality of user interface objects corresponding to different applications. In response to detecting the input that is directed to the placement location and in accordance with a determination that the input meets first criteria, including a duration criterion, one or more selectable options associated with the first user interface object corresponding to the first application are displayed. In response to detecting the input and in accordance with a determination that the input meets second criteria, wherein the second criteria requires that the input includes movement in a first direction, display of the first user interface object is replaced with display of the second user interface object from the plurality of user interface objects associated with the placement location.

Abstract: The invention provides compounds that modulate the activity of protein kinases that are associated with human diseases, disorders, and conditions. In particular, compounds of the invention inhibit LRRK2.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

Abstract: An electronic device includes a head mountable display having a sensor and a light seal removably connectable to the HMD. The light seal can include an identification feature detected by the sensor. In one example, the HMD includes a display screen configured to display a confirmatory image and the light seal can include a unique visual component corresponding to the confirmatory image. In another example, the HMD can include an optical lens connection feature and the sensor can detect a depth of the light seal.

Abstract: A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.

Abstract: Described herein is a fire-resistant adhesive coating composition which emits water vapor when exposed to fire. Such compositions comprise an ionic polyacrylate dispersant, aluminum hydroxide, silicate, and an alkoxylated alcohol. In certain embodiments, the composition comprises a solids content of at least about 44.2%, based on the wet weight of the composition. Also described herein are methods for making and using of such coating compositions.

Abstract: Methods of preparing monodisperse oligomer reagent compositions such as oligo(ethylene glycol) reagent compositions are described herein. The methods involve reacting a halo-terminated oligomer such as an oligo(ethylene oxide) having (m) monomers with a hydroxyl-terminated oligomer such as a hydroxyl-terminated oligo(ethylene oxide) having (n) monomers.

Abstract: The present disclosure describes compounds and compositions that inhibit ?-glucuronidase activity, and methods for attenuating the side effects of one or more drugs and improving the efficacy of drugs by administration of selective ?-glucuronidase inhibitors.

Abstract: A processor includes a processor core. A register of the core is to store: a bit range for a number of address bits of physical memory addresses used for key identifiers (IDs), and a first key ID to identify a boundary between non-restricted key IDs and restricted key IDs of the key identifiers. A memory controller is to: determine, via access to bit range and the first key ID in the register, a key ID range of the restricted key IDs within the physical memory addresses; access a processor state that a first logical processor of the processor core executes in an untrusted domain mode; receive a memory transaction, from the first logical processor, including an address associated with a second key ID; and generate a fault in response to a determination that the second key ID is within a key ID range of the restricted key IDs.

Abstract: A computing device includes signal generation circuitry and also includes a location on the computing device that is operative to couple a signal generated by the signal generation circuitry into a user. For example, the computing device includes signal generation circuitry that generates a signal that includes information corresponding to a user and/or an application that is operative within the computing device. The signal generation circuitry couples the signal into the user from a location on the computing device based on a bodily portion of the user being in contact with or within sufficient proximity to the location on the computing device that facilitates coupling of the signal into the user. Also, the signal may be coupled via the user to another computing device that includes a touchscreen display that is operative to detect and receive the signal.

Abstract: Systems of the present disclosure can provide a head-mountable device with a head securement element that allows a user to adjust both the magnitude, location, and direction of forces applied to the face of the user. Examples of adjustment mechanisms described herein allow a user to control the tilt of the head-mountable device relative to a head securement element, as well as the tightness of the head securement element. Accordingly, the user can select a fit that distributes forces widely, maximizes comfort, allows the user to enjoy the head-mountable device for longer durations of time.

Abstract: A capacitive imaging glove includes electrodes implemented throughout the capacitive imaging glove and drive-sense circuits (DSCs) such that a DSC receives a reference signal generates a signal based thereon. The DSC provides the signal to a first electrode via a single line and simultaneously senses it. Note the signal is coupled from the first electrode to the second electrode via a gap therebetween. The DSC generates a digital signal representative of the electrical characteristic of the first electrode. Processing module(s), when enabled, is/are configured to execute operational instructions (e.g., stored in and/or retrieved from memory) to generate the reference signal, process the digital signal to determine the electrical characteristic of the first electrode, and process the electrical characteristic of the first electrode to determine a distance between the first electrode and the second electrode, and generate capacitive image data representative of a shape of the capacitive imaging glove.

Abstract: The present disclosure provides for methods of making 1-Benzyl-4-Phenyl-1H-1,2,3-triazole (BPT) and structures having a coating of BPT.

Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: A method of forming a ceramic matrix composite (CMC) vane comprises drawing a continuous fiber sheet over at least one contoured surface to form a single-folded sheet. The single-folded sheet comprises an airfoil portion, a first platform at a first end of the airfoil portion, and an integral transition region between the airfoil portion and the first platform. The method further comprises mounting the airfoil portion on a mandrel, attaching a second platform to a second, opposing end of the airfoil portion to form a vane preform, and densifying the vane preform.