Abstract: The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.

Abstract: The invention relates to the technical field of communications, and more particularly, to a method and device for realizing synchronization. The method comprises: performing, by a base station, and according to an SRS signal transmitted by a terminal, filtering to obtain a RRU channel having the maximum receiving power in a current operation; upon determining that the RRU channel having the maximum receiving power in the current operation is different from a RRU channel used in the currently performed demodulation, refraining from performing immediate switching; and permitting switching of the RRU channel only when the receiving power of the RRU channel is determined to match the maximum threshold of a preset series of thresholds, and transmitting a TA command word to the terminal while switching the RRU channel to complete synchronization with the terminal. The invention prevents a terminal from frequently switching between RRU channels on a subframe basis.

Abstract: A method and an apparatus for cleaning a substrate are provided. The substrate (1010) comprises features (4034) of patterned structures. The method comprises placing the substrate on a substrate holder (1014) configured to rotate the substrate; applying cleaning liquid (1032) on the substrate; rotating the substrate by the substrate holder at a first rate when acoustic energy is being applied to the cleaning liquid by a transducer (1004); and rotating the substrate by the substrate holder at a second rate higher than the first rate when acoustic energy is not being applied to the cleaning liquid by the transducer.

Abstract: A substrate (2010, 3010, 4010, 5010, 6010, 7010, 8010) cleaning method is provided, it comprises the steps of: placing a substrate (2010, 3010, 4010, 5010, 6010, 7010, 8010) on a substrate holder (1314); delivering cleaning liquid onto the surface of the substrate (2010, 3010, 4010, 5010, 6010, 7010, 8010); implementing a pre-treatment process to detach bubbles (2050, 2052, 3050, 4050, 5050, 6050, 7052, 70584, 7056, 8052, 8054, 8056) from the surface of the substrate (2010, 3010, 4010, 5010, 6010, 7010, 8010); and then implementing an ultra or mega sonic cleaning process for cleaning the substrate (2010, 3010, 4010, 5010, 6010, 7010, 8010).

Abstract: An aircraft includes a fuselage defining a longitudinal axis between a forward end and an aft end. The aircraft includes an electrical system having an electric storage. The electric storage is positioned within the fuselage.

Abstract: A method for cleaning semiconductor substrate without damaging patterned structure on the substrate using ultra/mega sonic device comprising applying liquid into a space between a substrate and an ultra/mega sonic device; setting an ultra/mega sonic power supply at frequency f1 and power P1 to drive said ultra/mega sonic device; before bubble cavitation in said liquid damaging patterned structure on the substrate, setting said ultra/mega sonic power supply at frequency f2 and power P2 to drive said ultra/mega sonic device; after temperature inside bubble cooling down to a set temperature, setting said ultra/mega sonic power supply at frequency f1 and power P1 again; repeating above steps till the substrate being cleaned. Normally, if f1=f2, then P2 is equal to zero or much less than P1; if P1=P2, then f2 is higher than f1; if the f1<f2, then, P2 can be either equal or less than P1.

Abstract: Galectin 3 inhibitors and methods for treating sepsis using the same are provided herein.

Abstract: The present invention relates to applying at least one ultra/mega sonic device and its reflection plate for forming standing wave in a metallization apparatus to achieve highly uniform metallic film deposition at a rate far greater than conventional film growth rate in electrolyte. In the present invention, the substrate is dynamically controlled so that the position of the substrate passing through the entire acoustic field with different power intensity in each motion cycle. This method guarantees each location of the substrate to receive the same amount of total sonic energy dose over the interval of the process time, and to accumulatively grow a uniform deposition thickness at a rapid rate.

Abstract: Provided herein is an electronic message management platform that enables calculating a size of a sample of a message recipient list that delivers a confidence level greater than threshold for the entire message recipient list by applying a predicted bounce percent for the list to a sample size selection algorithm, selecting a total of recipients in the message recipient list that is consistent with the sample size, processing messages to each of the recipients in the sample, monitoring message life cycle events for the recipients in the sample set over a period of time, and based on the monitoring taking an action with the message recipient list selected from a list of recipient list actions consisting of processing remaining recipients in the message recipient list and halting processing of the message recipient list.

Abstract: Medical detectors and medical imaging devices are provided. In one aspect, a medical detector includes: a photoelectric conversion device, a first crystal array layer disposed over the photoelectric conversion device, and a second crystal array layer disposed over the first crystal layer. The first crystal array layer includes a plurality of first scintillation crystals arranged in a first crystal array, and a first coupling medium being filled between every adjacent two of the first scintillation crystals. The second crystal array layer includes a plurality of second scintillation crystals arranged in a second crystal array, and a second coupling medium being filled between every adjacent two of the second scintillation crystals. A light transmittance of the second coupling medium is different from a light transmittance of the first coupling medium.

Abstract: Disclosed are an intelligent bionic human body part model detection device and a method for manufacturing same. The device comprises: a bionic human body part model (1); and multiple optical fiber grating sensing units (5) which are integrated on an optical fibre and arranged at multiple pre-determined positions of the bionic human body part model (1). The device can improve the accuracy of the detection of pressure applied to the intelligent bionic human body part model.

Abstract: Improvements in speech recognition in a new domain are provided via the student/teacher training of models for different speech domains. A student model for a new domain is created based on the teacher model trained in an existing domain. The student model is trained in parallel to the operation of the teacher model, with inputs in the new and existing domains respectfully, to develop a neural network that is adapted to recognize speech in the new domain. The data in the new domain may exclude transcription labels but rather are parallelized with the data analyzed in the existing domain analyzed by the teacher model. The outputs from the teacher model are compared with the outputs of the student model and the differences are used to adjust the parameters of the student model to better recognize speech in the second domain.

Abstract: The present disclosure belongs to the field of washing machines, in particular relates to a washing barrel and a washing machine provided with the washing barrel. The washing barrel can accommodate washing water, a side wall of the washing barrel is provided with a drainage channel for discharging washing water in the washing barrel during dehydrating, and the drainage channel is provided with a water guiding part to guide washing water in the drainage channel to discharge rapidly. Through setting a water guiding part, washing water entering the drainage channel can be discharged rapidly along the drainage channel under the guidance of the water guiding part, and drainage can be realized with no need of reducing rotating speed of the washing barrel, thereby making the drainage smooth, reducing consumption of the motor which drives the washing barrel to rotate, and reducing vibration and noise of the whole machine.

Abstract: A phase-transition type vanadium oxide material and a preparation method therefor. The preparation method includes the following steps: providing a vanadium oxide base material, and implanting gaseous ions into the vanadium oxide base material, to obtain a phase-transition type vanadium oxide material having a preset phase-transition temperature. Subsequently, optionally, further annealing may be performed to adjust a bubble generation status in vanadium oxide after the gaseous ions are implanted, to further adjust the stress and strain and the phase-transition temperature. The method for preparing a phase-transition type vanadium oxide material consistent with the present invention has simple steps, desirable process reproducibility, high flexibility, and the phase-transition temperature of vanadium oxide can be continuously adjusted by changing an implantation dosage of the gaseous ions.

Abstract: A chemoenzymatic method for the preparation of a core-fucoslyated glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of a fucosylated GlcNAc-protein and fucosylated GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of an endoglycosidase (ENGase) selected from Endo;F1, Endo-F2, Endo-F3, Endo-D and related glycosynthase mutants to transfer the oligosaccharide moiety to the acceptor and yield the structure defined core-fucosylated glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of fucosylated glycoprotein or fucosylated glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody to include a predetermined sugar chain to replace a heterogeneous sugar chain, are also described.

Abstract: The present invention relates to the field of agriculture. In particular the invention provides a protein, a nucleic acid, a recombinant gene, plants comprising the recombinant gene and methods for altering the number of spikelets per spike of a wheat plant.

Abstract: A message processing method includes: acquiring a mark adding operation for at least a part of a target message; acquiring an input remarking message according to the mark adding operation; and outputting a marking identification for the remarking message. The marking identification can include the remarking message and an associative identification for associating the remarking message with the target message.

Abstract: The present invention provides for recombinant Endo-S mutants (named Endo-S glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

Abstract: Systems and methods for identifying a service region that includes sub-regions; calculating, for each pair of neighboring sub-regions, traffic data of computing devices traveling between the pair of sub-region; generating a directed graph representing the service region, the directed graph including nodes representing the sub-regions and the links between the nodes representing the first and the second traffic data; partitioning the directed graph into graph partitions, each graph partition including sub-graphs; calculating, for each sub-graph of each graph partition, a net traffic flow for the sub-graph based on a difference of the first and the second traffic data of the sub-regions that correspond to the nodes of the sub-graph; calculating, for each graph partition, a net traffic flow for the graph partition based on a summation of the net traffic flow of each sub-graph of the graph partition; identifying a particular graph partition having a smallest net traffic flow.

Abstract: The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.