Abstract: The present invention relates to devices and methods for coating surfaces including surfaces of medical devices, in particular the coating of microprojections on microprojection arrays. The present invention also relates to print head devices and their manufacture and to methods of using the print head devices for manufacturing articles such as microprojection arrays as well as to coating the surfaces of microprojection arrays. The present invention also relates to high throughput printing devices that utilize the print heads of the present invention.

Abstract: Provided are a recombinant expression vector for whooping cough antigens, an engineered bacterium and use thereof. The recombinant expression vector for whooping cough antigens comprises a protein expression cassette for pertactin, a gene for resistance screening, and an upstream recombinant nucleic acid fragment and a downstream recombinant nucleic acid fragment of filamentous haemagglutinin gene, wherein the protein expression cassette for pertactin is located between the upstream recombinant nucleic acid fragment and the downstream recombinant nucleic acid fragment of the filamentous haemagglutinin gene, and the upstream recombinant nucleic acid fragment and the downstream recombinant nucleic acid fragment of the filamentous haemagglutinin gene can undergo homologous recombination with the upstream and downstream of the filamentous haemagglutinin gene, respectively.

Abstract: The present invention relates to a layered semi-parallel LDPC decoder system having a single permutation network, and belongs to the field of decoder hardware design. The system comprises a layered decoding architecture of the single permutation network, a layered semi-parallel decoding architecture of the single permutation network, a pipeline design for layered semi-parallel decoding and a hardware framework of a layered semi-parallel LDPC decoder. The present invention removes a permutation network module between a check node and a variable node by modifying the cyclic shift value of each information block transferred from the variable node to the check node, i.e., the cyclic shift operation of the decoder can be completed through the single permutation network so as to reduce hardware resources of the decoder. A semi-parallel decoding structure is adopted, and meanwhile, a pipeline is added between half layers.

Abstract: A cooling system for an engine of an aircraft of a having hybrid-electric propulsion system including a nacelle body including a bottom cooling air intake disposed below a propeller hub for supplying air to an oil-air cooler, wherein the bottom cooling air intake includes a splitter dividing the bottom cooling air intake into a first channel and a second channel.

Abstract: To search for digital twins (avatars) on a computerized platform, a semantic embedding is made of the search query and this is compared with respective semantic embeddings generated for digital twins on the computerized platform, to determine a first set digital twins whose semantic embeddings are similar to that of the search query. A trained graph neural network generates respective graph embeddings of feature data of the first set of digital twins, and these graph embeddings are compared with graph embeddings that the trained graph neural network generates for other digital twins on the platform, to determine a second set of digital twins whose graph embeddings are similar to graph embeddings of the first set of digital twins. The search results returned in response to the search query may include at least one digital twin in the second set of digital twins.

Abstract: A method for cleaning substrates includes rotating a substrate; delivering deionized water on a surface of the substrate for pre wetting the surface of the substrate; delivering chemical solution with high temperature on the surface of the substrate for cleaning the surface of the substrate; changing the rotation speed of the substrate to a low rotation speed, and moving a ultra/mega sonic device. The method further includes turning on the ultra/mega sonic device and supplying a constant or pulse working power in a first cleaning cycle; turning off the ultra/mega sonic device, and delivering a high temperature chemical solution or deionized water. The method further includes turning on the ultra/mega sonic device and supplying a constant or pulse working power in a second cleaning cycle; turning off the ultra/mega sonic device, and delivering rinse chemical solution or deionized water on the surface of the substrate; and drying the substrate.

Abstract: A substrate processing apparatus includes a clamp mechanism, a spray head mechanism, a rotary drive mechanism, a heating mechanism, and a control mechanism. The heating mechanism includes a heating plate arranged below a substrate, wherein the heating plate is provided with at least two cavities in a radial direction, and the cavities are distributed at different radii. During the process of the liquid nozzle moving from the center of the substrate to the edge of the substrate along the radial direction of the substrate, when the liquid nozzle moves to a certain area above the substrate, the control mechanism controls the thermal energy of fluid in the cavity located at the corresponding radius of the area.

Abstract: The present invention relates to devices and methods for coating surfaces including surfaces of medical devices, in particular the coating of microprojections on microprojection arrays. The present invention also relates to print head devices and their manufacture and to methods of using the print head devices for manufacturing articles such as microprojection arrays as well as to coating the surfaces of microprojection arrays. The present invention also relates to high throughput printing devices that utilize the print heads of the present invention.

Abstract: A method (100) of analyzing a medical report (34) presenting clinical content determined from one or more images (38) includes: extracting a text embedding (54) from the medical report: extracting an image embedding (52) from the one or more images; determining one or more content feature vectors from the text embedding and the image embedding; determining one or more style feature vectors from the text embedding; and at least one of: extracting one or more clinical findings contained in the medical report using the one or more content feature vectors; scoring the style of the medical report using the one or more style feature vectors; and/or converting the medical report to a target style using the one or more content feature vectors and one or more target style feature vectors different from the determined one or more style feature vectors.

Abstract: An engine assembly includes a propulsor, a gearbox, an engine, a gas turbine engine, and an electric control assembly. The gearbox includes a gear assembly coupled with the propulsor. The engine includes an air inlet, an exhaust outlet, and an engine output shaft. The engine output shaft is coupled with the gear assembly and configured to drive rotation of the propulsor through the gear assembly. The gas turbine engine includes a first rotational assembly, a compressor section, a turbine section, and a combustor. The compressor section is connected to the air inlet. The combustor is connected to the exhaust outlet. The combustor is configured to direct a combustion gas through the turbine section to drive rotation of the first rotational assembly. The electric control assembly includes a first electric motor. The first electric motor is coupled with the gear assembly. The first electric motor is configured to selectively apply a rotational force to the gear assembly to further drive rotation of the propulsor.

Abstract: A VTOL (vertical take-off and landing) rotorcraft with distributed propulsion system having the capability to convert between VTOL (vertical take-off and landing) flight and airplane flight. The rotorcraft includes a fuselage, a tail boom or tail fin, a pair of wings, a pair of transversally extended forward pivotable rotor booms, a plurality of forward proprotors mounted to the pivotable rotor booms, a plurality of rear lift rotors mounted to the tail boom, and a stabilizer mounted on the tail boom or tail fin. The proprotor and lift rotor can be open rotor or ducted rotor. The proprotors in a first configuration and lift rotors provide the thrust vector for VTOL (vertical take-off and landing) flight. Moreover, the proprotors in a second configuration provide the forward propulsive thrust in airplane flight.

Abstract: The present disclosure provides a one-pot chemoenzymatic method for site-specific modification and conjugation of antibodies at their Fc glycan site to produce structurally well-defined antibody conjugates carrying defined drugs and other entities. The method is enabled by the discovery that certain endoglycosidases have the ability to both deglycosylate an antibody and to recognize selectively modified small disaccharide oxazolines for transglycosylation on antibodies without hydrolysis of the resulting products.

Abstract: A dental floss device, which includes a shell, a floss supply box, and a drive device; the floss supply box includes a box arranged in an accommodating cavity of the shell; a floss supply assembly mounted in the box, the floss supply assembly is capable of recovering an used floss and releasing an unused floss under driving of the drive device; a floss holder, one end of the floss holder is connected with the floss supply assembly, and another end of the floss holder is capable of extending out of the shell, the floss holder is configured to stretch a floss released by the floss supply assembly; the box, the floss supply assembly and the floss holder are made of degradable or recyclable materials.

Abstract: The present disclosure provides a one-pot chemoenzymatic method for site-specific modification and conjugation of antibodies at their Fc glycan site to produce structurally well-defined antibody conjugates carrying defined drugs and other entities. The method is enabled by the discovery that certain endoglycosidases have the ability to both deglycosylate an antibody and to recognize selectively modified small disaccharide oxazolines for transglycosylation on antibodies without hydrolysis of the resulting products.

Abstract: The invention is for a VTOL (vertical take-off and landing) rotorcraft with the annular contra-rotating rotary wings and auxiliary propulsor. The rotary wing of the annular contra-rotating rotary wings is driven by a plurality of tangential forces applied at multiple locations of the inner stator hub. The annular contra-rotating rotary wings can be shrouded for the improvement of propulsive efficiency, reduction of noise and protection of the rotary wing. The fuselage is mounted along the center axis of the annular contra-rotating rotary wings to be outside of the thrust slipstream. The auxiliary propulsor includes a quad independent pusher propeller to propel the rotorcraft to reach faster forward speed.

Abstract: Disclosed are an automatic remote water supply system in a low gravity environment, which includes a water supply unit, an environment detection unit and a control unit. The water supply unit includes a water bag, an air inlet pipe, a water pipe and a water pump on the water pipe. The bottom of the water bag has an air inlet and a water outlet. The air inlet pipe is communicated with the water bag through the air inlet. The water pipe is communicated with the water bag through the water outlet. The environment detection unit is configured to detect environmental information in the ecosystem to which the water supply system belongs in the low gravity environment. The control unit is configured to control the starting state of the water pump according to the environmental information, so that water in the water bag flows out through the water pipe.

Abstract: The present invention relates to a pharmaceutical combination comprising a PCSK9 inhibitor and a GLP-1 receptor agonist; The invention also relates to the use of the pharmaceutical combination in preparing drugs for treating hyperglycemia, diabetes, obesity and/or cholesterol related diseases.

Abstract: A power battery heating system of an electric vehicle including: a heating module configured to heat the power battery of the electric vehicle; a solar sunroof; and a sunroof control unit configured to control the operation of the heating module and the electric energy output of the solar sunroof; wherein the heating system is configured to start a power battery heating operation based on the solar sunroof when the power battery is not in a high voltage output state and the temperature of the power battery is lower than a temperature threshold, the power battery heating operation including: controlling the solar sunroof to output electric energy to the heating module such that the heating module performs the heating of the power battery using the electric energy from the solar sunroof.