Abstract: A contactless card includes an arrangement of a plurality of tactile sensors along the edge, an arrangement of a plurality of tactile sensors on the surface or surfaces, an arrangement of a plurality tactile of sensors along the edge and on the surface or surfaces. The arrangement of a plurality of tactile sensors captures the interaction of the user's hand and the contactless card to generate a unique binary string. In addition to the validation of the identifying information embedded within the memory of any existing contactless credit card, debit cards, prepaid electronic cash card, loyalty card and access card, the user's identification is also validated through the binary string. An irreversible mathematical equation can be used to compute the identifying information and binary string to generate the validation Radio Frequency Identification signal.

Abstract: A computer implemented method, computer program product, and system for managing execution of a workflow comprising a set of subworkflows, comprising optimizing the set of subworkflows using a deep neural network, wherein each subworkflow of the set of subworkflows has a set of tasks, wherein each task of the sets of tasks has a requirement of resources of a set of resources; wherein each task of the sets of tasks is enabled to be dependent on another task of the sets of tasks, training the deep neural network by: executing the set of subworkflows, collecting provenance data from the execution, and collecting monitoring data that represents the state of said set of resources, wherein the training causes the neural network to learn relationships between the states of said set of resources, the said sets of tasks, their parameters and the obtained performance, optimizing an allocation of resources of the set of resources to each task of the sets of tasks to ensure compliance with a user-defined quality metric b

Abstract: A method and apparatus for generating a speech waveform. Fundamental frequency information, glottal features and vocal tract features associated with an input may be received, wherein the glottal features include a phase feature, a shape feature, and an energy feature (1310). A glottal waveform is generated based on the fundamental frequency information and the glottal features through a first neural network model (1320). A speech waveform is generated based on the glottal waveform and the vocal tract features through a second neural network model (1330).

Abstract: A VTOL (vertical take-off and landing) rotorcraft with distributed propulsion system having the capability to convert to airplane flight. The rotorcraft includes a short fuselage, a pair of wings, a pair of inboard booms, a plurality of outboard booms, an empennage, a plurality of lift rotors, and a plurality of proprotors. The fuselage, the wings, inboard booms and V-tail are mechanically coupled together. The plurality of outboard booms is mounted to the wings. Moreover, the proprotors and lift rotors are mounted on the inboard and outboard boom. The placement of the lift rotors allows the rotorcraft to benefit from the reliable and agile function of the quadcopter. The plurality of proprotors in a first configuration provides additional lift thrust for VTOL flight and a second configuration provides forward propulsive thrust in airplane flight.

Abstract: The present invention discloses an electric heating thermal management system for an oil and gas transportation pipeline based on renewable energy and CO2 energy storage. It transmits the feedback data value through a data collection device arranged in the pipeline to the early warning device by the control device. After analysis and processing, the early warning device can feed back the data value to the control device and the remote operation device in two modes. Different degrees of heating amount can be generated for the oil and gas transportation pipelines at different positions in different modes. Hierarchical and distributed management control for the oil and gas transportation pipelines can be targetedly conducted in unblocked, easily blocked and blocked positions of the oil and gas transportation pipeline. The present invention couples the renewable energy electricity supply device and the CO2 energy storage device.

Abstract: Disclosed are an intelligent bionic human body part model detection device and a method for manufacturing same. The device comprises: a bionic human body part model (1); and multiple optical fiber grating sensing units (5) which are integrated on an optical fibre and arranged at multiple pre-determined positions of the bionic human body part model (1). The device can improve the accuracy of the detection of pressure applied to the intelligent bionic human body part model.

Abstract: The present invention discloses a method for cleaning substrate without damaging patterned structure on the substrate using ultra/mega sonic device, comprising: applying liquid into a space between a substrate and an ultra/mega sonic device; setting an ultra/mega sonic power supply at frequency f1 and power P1 to drive said ultra/mega sonic device; after micro jet generated by bubble implosion and before said micro jet generated by bubble implosion damaging patterned structure on the substrate, setting said ultra/mega sonic power supply at frequency f2 and power P2 to drive said ultra/mega sonic device; after temperature inside bubble cooling down to a set temperature, setting said ultra/mega sonic power supply at frequency f1 and power P1 again; repeating above steps till the substrate being cleaned.

Abstract: The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

Abstract: A method may include obtaining an image of a scene from a first perspective, the image including an object, and detecting the object in the image using a machine learning process, where the object may be representative of a known shape with at least four vertices at a first set of points. The method may also include automatically predicting a second set of points corresponding to the at least four vertices of the object in a second perspective of the scene based on the known shape of the object. The method may additionally include constructing, without user input, a transformation matrix to transform a given image from the first perspective to the second perspective based on the first set of points and the second set of points.

Abstract: Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain, where it breaks down neurotransmitters and thereby influences mood and behavior. While small molecule MAO inhibitors (MAOIs) have been developed used for treating depression and other neurological disorder, the involvement of MAO-A in antitumor immunity has not been known. The disclosure provided herein identifies MAO-A as an immune checkpoint and the use of MAOI antidepressants for cancer immunotherapy. Here we report induction of the Maoa gene in tumor-infiltrating immune cells. MAOI treatment significantly suppressed tumor growth in preclinical mouse syngeneic and human xenograft tumor models in a T cell-dependent manner. Combining MAOI and anti-PD-1 treatments generated synergistic tumor suppression effects. Clinical data correlation studies associated intratumoral MAOA expression with T cell dysfunction and impaired patient survival in a broad range of cancers.

Abstract: We have discovered MAO-A induction in mouse and human TAMs. Moreover, we determined that MAO-A-deficient mice exhibited decreased TAM immunosuppressive functions corresponding with enhanced antitumour immunity. Building upon these discoveries, we then determined that MAOI treatment induced TAM reprogramming and suppressed tumour growth in preclinical mouse syngeneic and human xenograft tumour models. Surprisingly, combining MAOI and anti-PD-1 treatments resulted in synergistic tumour suppression. Together, these data identify MAO-A as a critical regulator of TAMs, and that show that repurposing MAOIs for TAM reprogramming can be used to improve cancer immunotherapies.

Abstract: A detection device, an inverter, and a detection method are disclosed. The detection device is configured to detect a leakage current flowing through a conductor. The detection device includes a magnetic core, a detection winding and a calibration winding both wound on the magnetic core, a detection circuit, and a calibration circuit. The detection circuit is coupled to the detection winding, and configured to sample a detection signal of the detection winding to obtain a leakage current detection value. The calibration circuit is coupled to the calibration winding, and configured to provide a calibration signal to the calibration winding.

Abstract: An aircraft includes a fuselage defining a longitudinal axis between a forward end and an aft end. The aircraft includes an electrical system having an electric storage. The electric storage is positioned within the fuselage.

Abstract: Disclosed are a cloud safety computing method, a device and a storage medium based on cloud fault-tolerant technology. The cloud safety computing method includes following steps: S1, adopting a one-master multiple-slave fault-tolerant architecture for management nodes, and using KeepAlived and Haproxy to realize a liveness self-check of the management nodes and a load balancing of user requests, and S2, adopting a dynamic redundancy fault-tolerant safety design for service nodes to maintain a life cycle of application microservices, and giving feedback on liveness information to the management nodes in real time through heartbeat by the service nodes, where the application microservices report the life cycle to the management nodes based on a probe mechanism, and the application microservices exchange input and output information through redundancy voting.

Abstract: A system is provided for an aircraft. This aircraft system includes a rotor, a powerplant, a battery and a heating system. The powerplant is configured to drive rotation of the rotor. The powerplant includes a heat engine and an electric machine. The battery is electrically coupled with the electric machine. The heating system includes an electric heating element. The heating system is configured to heat the battery using the electric heating element.

Abstract: The present invention provides for the use of recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

Abstract: The present disclosure provides a one-pot chemoenzymatic method for site-specific modification and conjugation of antibodies at their Fc glycan site to produce structurally well-defined antibody conjugates carrying defined drugs and other entities. The method is enabled by the discovery that certain endoglycosidases have the ability to both deglycosylate an antibody and to recognize selectively modified small disaccharide oxazolines for transglycosylation on antibodies without hydrolysis of the resulting products.

Abstract: A method may include obtaining a first image of a first view. The first illustrated by the first image may be defined by one or more viewing parameters. The method may also include acquiring, from a machine learning system, a location of an object within the first image, calculating a relative position of the object within the first image using the location of the object within the first image, and determining whether the relative position of the object satisfies a condition. In response to the relative position of the object not satisfying the condition, at least one of the viewing parameters may be adjusted based on the relative position of the object and the condition. The method may further include obtaining a second image of a second view. The second view illustrated by the second image may be defined by the adjusted at least one of the viewing parameters.

Abstract: A rock true triaxial dynamic compression-shear test equipment, and method under deep complex structure conditions, includes a counterforce framework, a pressure chamber, a base platform and four actuators. A pressure chamber transfer track is arranged on the base platform, and a pressure chamber transfer slipway is arranged on the tracks. The pressure chamber is a split structure. A pressure chamber base is located on the pressure chamber transfer slipway, and a pressure chamber barrel is provided with a pressure chamber barrel lift type bearing table and a pressure chamber barrel hoisting mechanism. The pressure chamber is provided with pressure chamber barrel and base packaging fixtures.

Abstract: A VTOL (vertical take-off and landing) box-wing aerial vehicle with multirotor to provide VTOL flight includes a detachable cabin, centered fuselage, a pair of first wings extending outward from the upper portion of the fuselage and a pair of second wings extending outwardly and from the lower portion of the fuselage. The first and second wings are spaced apart longitudinally and vertically. The pylon joints the first wing and second wing at the tip to form the box-wing. The pylon includes heading control rudder. Secured to the wing or pylon or both wing and pylon, an overhead boom extending longitudinally to support a plurality of lift rotors or tiltable rotors for VTOL flight. Finally, the overhead boom mounted tiltable rotors propel the vehicle forward to generate lift from the wings. Furthermore, the wings are equipped with elevators and ailerons for flight control.