Abstract: A method may include obtaining an image of a scene from a first perspective, the image including an object, and detecting the object in the image using a machine learning process, where the object may be representative of a known shape with at least four vertices at a first set of points. The method may also include automatically predicting a second set of points corresponding to the at least four vertices of the object in a second perspective of the scene based on the known shape of the object. The method may additionally include constructing, without user input, a transformation matrix to transform a given image from the first perspective to the second perspective based on the first set of points and the second set of points.

Abstract: Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain, where it breaks down neurotransmitters and thereby influences mood and behavior. While small molecule MAO inhibitors (MAOIs) have been developed used for treating depression and other neurological disorder, the involvement of MAO-A in antitumor immunity has not been known. The disclosure provided herein identifies MAO-A as an immune checkpoint and the use of MAOI antidepressants for cancer immunotherapy. Here we report induction of the Maoa gene in tumor-infiltrating immune cells. MAOI treatment significantly suppressed tumor growth in preclinical mouse syngeneic and human xenograft tumor models in a T cell-dependent manner. Combining MAOI and anti-PD-1 treatments generated synergistic tumor suppression effects. Clinical data correlation studies associated intratumoral MAOA expression with T cell dysfunction and impaired patient survival in a broad range of cancers.

Abstract: We have discovered MAO-A induction in mouse and human TAMs. Moreover, we determined that MAO-A-deficient mice exhibited decreased TAM immunosuppressive functions corresponding with enhanced antitumour immunity. Building upon these discoveries, we then determined that MAOI treatment induced TAM reprogramming and suppressed tumour growth in preclinical mouse syngeneic and human xenograft tumour models. Surprisingly, combining MAOI and anti-PD-1 treatments resulted in synergistic tumour suppression. Together, these data identify MAO-A as a critical regulator of TAMs, and that show that repurposing MAOIs for TAM reprogramming can be used to improve cancer immunotherapies.

Abstract: An aircraft includes a fuselage defining a longitudinal axis between a forward end and an aft end. The aircraft includes an electrical system having an electric storage. The electric storage is positioned within the fuselage.

Abstract: A detection device, an inverter, and a detection method are disclosed. The detection device is configured to detect a leakage current flowing through a conductor. The detection device includes a magnetic core, a detection winding and a calibration winding both wound on the magnetic core, a detection circuit, and a calibration circuit. The detection circuit is coupled to the detection winding, and configured to sample a detection signal of the detection winding to obtain a leakage current detection value. The calibration circuit is coupled to the calibration winding, and configured to provide a calibration signal to the calibration winding.

Abstract: The present invention provides for the use of recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

Abstract: Disclosed are a cloud safety computing method, a device and a storage medium based on cloud fault-tolerant technology. The cloud safety computing method includes following steps: S1, adopting a one-master multiple-slave fault-tolerant architecture for management nodes, and using KeepAlived and Haproxy to realize a liveness self-check of the management nodes and a load balancing of user requests, and S2, adopting a dynamic redundancy fault-tolerant safety design for service nodes to maintain a life cycle of application microservices, and giving feedback on liveness information to the management nodes in real time through heartbeat by the service nodes, where the application microservices report the life cycle to the management nodes based on a probe mechanism, and the application microservices exchange input and output information through redundancy voting.

Abstract: A system is provided for an aircraft. This aircraft system includes a rotor, a powerplant, a battery and a heating system. The powerplant is configured to drive rotation of the rotor. The powerplant includes a heat engine and an electric machine. The battery is electrically coupled with the electric machine. The heating system includes an electric heating element. The heating system is configured to heat the battery using the electric heating element.

Abstract: The present disclosure provides a one-pot chemoenzymatic method for site-specific modification and conjugation of antibodies at their Fc glycan site to produce structurally well-defined antibody conjugates carrying defined drugs and other entities. The method is enabled by the discovery that certain endoglycosidases have the ability to both deglycosylate an antibody and to recognize selectively modified small disaccharide oxazolines for transglycosylation on antibodies without hydrolysis of the resulting products.

Abstract: A method may include obtaining a first image of a first view. The first illustrated by the first image may be defined by one or more viewing parameters. The method may also include acquiring, from a machine learning system, a location of an object within the first image, calculating a relative position of the object within the first image using the location of the object within the first image, and determining whether the relative position of the object satisfies a condition. In response to the relative position of the object not satisfying the condition, at least one of the viewing parameters may be adjusted based on the relative position of the object and the condition. The method may further include obtaining a second image of a second view. The second view illustrated by the second image may be defined by the adjusted at least one of the viewing parameters.

Abstract: A VTOL (vertical take-off and landing) box-wing aerial vehicle with multirotor to provide VTOL flight includes a detachable cabin, centered fuselage, a pair of first wings extending outward from the upper portion of the fuselage and a pair of second wings extending outwardly and from the lower portion of the fuselage. The first and second wings are spaced apart longitudinally and vertically. The pylon joints the first wing and second wing at the tip to form the box-wing. The pylon includes heading control rudder. Secured to the wing or pylon or both wing and pylon, an overhead boom extending longitudinally to support a plurality of lift rotors or tiltable rotors for VTOL flight. Finally, the overhead boom mounted tiltable rotors propel the vehicle forward to generate lift from the wings. Furthermore, the wings are equipped with elevators and ailerons for flight control.

Abstract: A rock true triaxial dynamic compression-shear test equipment, and method under deep complex structure conditions, includes a counterforce framework, a pressure chamber, a base platform and four actuators. A pressure chamber transfer track is arranged on the base platform, and a pressure chamber transfer slipway is arranged on the tracks. The pressure chamber is a split structure. A pressure chamber base is located on the pressure chamber transfer slipway, and a pressure chamber barrel is provided with a pressure chamber barrel lift type bearing table and a pressure chamber barrel hoisting mechanism. The pressure chamber is provided with pressure chamber barrel and base packaging fixtures.

Abstract: A method for controlling damages in cleaning a semiconductor wafer comprising features of patterned structures, the method comprising: delivering a cleaning liquid over a surface of a semiconductor wafer during a cleaning process; and imparting sonic energy to the cleaning liquid from a sonic transducer during the cleaning process, wherein power is alternately supplied to the sonic transducer at a first frequency and a first power level for a first predetermined period of time and at a second frequency and a second power level for a second predetermined period of time, the first predetermined period of time and the second predetermined period of time consecutively following one another, wherein at least one of the cleaning parameters is determined such that a percentage of damaged features as a result of the imparting sonic energy is lower than a predetermined threshold.

Abstract: An aircraft includes a fuselage defining a longitudinal axis between a forward end and an aft end. The aircraft includes an electrical system having an electric storage. The electric storage is positioned within the fuselage.

Abstract: A system for controlling damages in cleaning a semiconductor wafer comprising features of patterned structures, the system comprising: a wafer holder for temporary restraining a semiconductor wafer during a cleaning process; an inlet for delivering a cleaning liquid over a surface of the semiconductor wafer; a sonic generator configured to alternately operate at a first frequency and a first power level for a first predetermined period of time and at a second frequency and a second power level for a second predetermined period of time, to impart sonic energy to the cleaning liquid, the first predetermined period of time and the second predetermined period of time consecutively following one another; and a controller programmed to provide the cleaning parameters, wherein at least one of the cleaning parameters is determined such that a percentage of damaged features as a result of the imparting sonic energy is lower than a predetermined threshold.

Abstract: This disclosure includes a method of protecting crops from a variety of fungal, bacterial and viral diseases, especially from Cercospora leaf spots, downy mildews, powdery mildews and Botrytis diseases by the seed treatment and/or irrigation and/or the foliar application of multiple components compositions. The compositions contain at least two elicitors of systemic plant self-defenses, including RBs and Chitin or Chitosan or their derivatives.

Abstract: The present invention discloses an electric heating thermal management system for an oil and gas transportation pipeline based on renewable energy and CO2 energy storage. It transmits the feedback data value through a data collection device arranged in the pipeline to the early warning device by the control device. After analysis and processing, the early warning device can feed back the data value to the control device and the remote operation device in two modes. Different degrees of heating amount can be generated for the oil and gas transportation pipelines at different positions in different modes. Hierarchical and distributed management control for the oil and gas transportation pipelines can be targetedly conducted in unblocked, easily blocked and blocked positions of the oil and gas transportation pipeline. The present invention couples the renewable energy electricity supply device and the CO2 energy storage device.

Abstract: Systems and methods including identifying a physical intelligent moving object (IMO), the physical IMO associated with a current location and a service request; creating, from a digital representation template that is based on the service request, a digital representation instance of the physical IMO in a particular edge cloud of a distributed cloud computing environment that is closest to the current location of the physical IMO; in response to creating the digital representation instance, establishing a network connection between the digital representation and the physical IMO using the particular edge cloud; detecting a movement of the physical IMO from coverage of the particular edge cloud; in response to detecting the movement of the physical IMO: identifying a target edge cloud of the distributed cloud computing environment for coverage of the physical IMO; and establishing a network connection between the digital representation and the physical IMO using the target edge cloud.

Abstract: The present disclosure provides a device and method for diagnosing risk of insufficient hole cleaning problem during drilling wells. The method includes obtaining the measured pressure via several measuring points, and obtaining actually measured value of each measuring point; calculate the theoretical pressure at each measuring points by using the real-time operational data as inputs, evaluating a hole cleaning condition by applying a difference between a theoretical pressure drop and a measured pressure drop to a developed pressure driven hole cleaning model, which gives the risk of insufficient hole cleaning problems and problematic locations. The theoretical pressure drop between two adjacent measurement points along wellbore includes the pressure drop caused by friction effect and hydrostatic effect. However, suspended cuttings in actual drilling fluid may significantly change the pressure drop along wellbore.

Abstract: A method of managing oilfield activity with a control system is provided having a plurality of virtual sensors and integrating the virtual sensors into a virtual sensor network. The method includes determining interdependencies among the virtual sensors, obtaining operational information from the virtual sensors, and providing virtual sensor output to the control system based on the determined interdependencies and the operational information.