Abstract: The present invention discloses a packaging box that displays different images when open and closed, which comprises an outer box body and an inner box body. A display window is provided on the upper face of the outer box body. Different images are displayed in the display window on the unfolded surface or the closed surface. The unfolded surface is fixed in the display window. Opening and closing the inner box body drives the lateral movement of the closed surface to display the image on the unfolded surface or the image on the closed surface in the display window. The invention also discloses a preparation method and application of the packaging box.

Abstract: An additive manufacturing apparatus includes a support plate including a window. A stage is configured to hold one or more cured layers of the resin to form a component. A radiant energy device positioned on an opposite side of the support plate from the stage and operable to generate and project radiant energy in a patterned image through the window. An actuator is operably coupled with the stage and is configured to move the stage between a curing position and a removal position. The curing position can be offset from the removal position.

Abstract: A method is provided for casting a component. Accordingly, data indicative of at least one location of a unitary core-shell mold which is susceptible to a stress concentration is received. An additive manufacturing process is employed to form the unitary core-shell mold defining a casting cavity. The unitary core-shell mold includes a shell wall defining an outer component shape and a core wall positioned inward of the shell wall. The core wall defines an inner component shape. The core wall and/or the shell wall defines at least one reinforcement recess adjacent to the at least one location which is susceptible to the stress concentration. Following the forming of the unitary core-shell mold, at least one support member is positioned within the reinforcement recess in contact with the at least one location. With the support member in place, the component is cast within the casting cavity.

Abstract: Provided are a method for constructing a library based on an RNA sample and uses thereof. The method includes: step 1 of subjecting the RNA sample to a reverse transcription reaction to obtain DNA-RNA hybrid strands; step 2 of performing reaction of the DNA-RNA hybrid strands with an endoribonuclease, a first DNA polymerase, a second DNA polymerase, and dATPs to obtain a double-stranded DNA added with dA-tail, where the first DNA polymerase has a 5?-3? exonuclease activity and a 3?-5? exonuclease activity, and the second DNA polymerase has no 3?-5? exonuclease activity; step 3 of ligating the double-stranded DNA added with dA-tail and a sequencing adaptor to obtain a ligated product; and step 4 of subjecting the ligated product to PCR amplification to obtain a sequencing library.

Abstract: An additive manufacturing apparatus includes a support plate defining a window and a resin support configured to support an uncured layer of resin. A stage is configured to hold one or more cured layers of the resin to form a component positioned opposite a support plate. A radiant energy device is positioned on an opposite side of the resin support from the stage and is operable to generate and project radiant energy in a patterned image through the window. The stage is configured to move simultaneously with the resin support from a first position to a second position in an X-axis direction.

Abstract: A multimodal fusion detection apparatus and method based on optical pumping and photoacoustic imaging are provided, relating to the field of fusion detection technology. In the apparatus, the atomic vapor cell detection path and the first laser irradiation path are both directed toward a target region and at least partially overlap. In this way, the detection paths of optical pumping and photoacoustic imaging are at least partially coincident, ensuring that electrophysiological signals and blood oxygen signals originate from the same tissue region and avoiding the spacing constraints of conventional sensors. Thus, the detection path of the atomic vapor cell can be used for both magnetic field detection and photoacoustic detection, enabling simultaneous acquisition of magnetic and photoacoustic signals at a single detection point, achieving hardware reuse for multimodal fusion detection at the same location and time, reducing device size, and minimizing crosstalk among multimodal sensors.

Abstract: A binder solution comprises a fugitive metal precursor, a thermoplastic binder, and a solvent. The fugitive metal precursor may comprise an alkaline earth metal, a transition metal, a post-transition metal, a metalloid, a rare earth metal, or combinations thereof. The fugitive metal precursor may comprise a salt such as carboxylate, nitrate, sulfate, carbonate, formate, chloride, halide, derivatives thereof, and combinations thereof. A method of manufacturing a part includes depositing a layer of particulate material on a working surface, selectively applying a binder solution into the layer of particulate material in a pattern representative of a layer of the part, repeating the steps of depositing and selectively applying to form a plurality of layers of particulate material with the applied binder solution, and curing the applied binder solution in the plurality of layers of particulate material with the applied binder solution to evaporate the solvent and form a green body part.

Abstract: An array substrate includes a substrate, a first gate line, a plurality of data lines, a plurality of first pixel electrodes, a plurality of first transistors and a plurality of first capacitive lines that are all disposed on the substrate. A data line and the first gate line cross, and are insulated from each other. An orthographic projection of a first capacitive line on the substrate is overlapped with an orthographic projection of a first pixel electrode on the substrate. The first capacitive line includes a first conductive segment that is proximate to the first gate line and is provided with a first break therein. An orthographic projection, on the substrate, of a portion of the first conductive segment located on a side of the first break away from the middle subsection is overlapped with an orthographic projection of a second electrode of a first transistor on the substrate.

Abstract: A binder solution comprises a fugitive metal precursor, a thermoplastic binder, and a solvent. The fugitive metal precursor may comprise an alkaline earth metal, a transition metal, a post-transition metal, a metalloid, a rare earth metal, or combinations thereof. The fugitive metal precursor may comprise a salt such as carboxylate, nitrate, sulfate, carbonate, formate, chloride, halide, derivatives thereof, and combinations thereof. A method of manufacturing a part includes depositing a layer of particulate material on a working surface, selectively applying a binder solution into the layer of particulate material in a pattern representative of a layer of the part, repeating the steps of depositing and selectively applying to form a plurality of layers of particulate material with the applied binder solution, and curing the applied binder solution in the plurality of layers of particulate material with the applied binder solution to evaporate the solvent and form a green body part.

Abstract: A method of forming a component that includes identifying an acute angle in an original model that is a virtual model of the component. The acute angle is defined by a first surface and a second surface. The method includes compensating the original model at the acute angle to create a compensated acute angle in a compensated model. The method also includes forming, by additive manufacturing, the component based upon the compensated model, where the formed component is more alike the original model than the compensated model.

Abstract: A method for a quality detection of tunnel lining through ground-penetrating radar based on self-supervised learning. In the method, a grayscale image of the tunnel to be detected is obtained, the grayscale image is then input into a trained feature recognition model, to obtain a feature atlas is corresponding to the grayscale image, and then a quality recognition result of the tunnel to be detected is determined according to the feature atlas. In the present application, the feature recognition model is obtained by means of the self-supervised learning according to an unlabeled image set and a labeled image set, and the unlabeled image set is directly utilized to train the recognition model, which not only improves the efficiency of training the tunnel recognition model, but also improves the accuracy of tunnel quality detection results.

Abstract: A method, apparatus and device for determining tooth restoration data, and a storage medium are provided. A real tooth model of a target object and a standard prepared tooth model corresponding to the real tooth model are acquired. The real tooth model includes a tooth to be prepared, the standard prepared tooth model includes a standard prepared body corresponding to the tooth to be prepared, and the standard prepared body is a standard prepared tooth for wearing a prosthesis. The tooth to be prepared in the real tooth model is compared with the standard prepared body in the standard prepared tooth model, so as to obtain data to be restored of the tooth to be prepared. The data to be restored is data to be ground that corresponds to the restoration of the tooth to be prepared to the standard prepared body.

Abstract: An additive manufacturing apparatus can include a stage configured to hold one or more cured layers of resin that form a component. A radiant energy device can be operable to generate and project radiant energy in a patterned image. An actuator can be configured to change a relative position of the stage relative to the radiant energy device. A reclamation system can be downstream of the stage and can be configured to remove at least a portion of the resin from a resin support. The reclamation system can include a first collection structure configured to accept a resin support along a resin support movement direction. A first scraper is positioned within the first collection structure. The first scraper has an elongation axis that is offset from the resin support movement direction by an offset angle that is less than 90 degrees.

Abstract: Provided are an alphaxalone fat emulsion injection and a method for preparing same. The alphaxalone fat emulsion injection comprises alphaxalone and a pharmaceutically acceptable salt thereof, an oil phase, an emulsifier, a co-emulsifier, an osmotic pressure regulator, a stabilizer, a pH value regulator, and water for injection.

Abstract: The present application relates to a composition of reducing and/or inhibiting protein carbonylation including polylysines. The present application further relates to a method of protecting skin from carbonylation stimuli by using a composition including polylysines, and relates to a non-therapy cosmetic method for caring for keratin materials, especially the skin, by applying the composition of reducing and/or inhibiting protein carbonylation including polylysines.

Abstract: A method for cleaning an additively manufactured part, the method comprising: contacting a cast layer with a build plate. The cast layer is disposed on a first side of a foil sheet and has a surface height spaced vertically above the foil sheet along a first axis. The build plate is vertically spaced above the foil sheet along the first axis. The method includes moving the build plate along the first axis to position a build surface at a cure depth below the surface height of the cast layer to form a segment of a printed part on the build surface. The method includes moving the build plate along the first axis to position the segment of the printed part above the cure depth and translating the foil sheet along a second axis to clean the segment of the printed part within the cast layer.

Abstract: Disclosed are an anti-CD40 antibody, an anti-PD-L1×CD40 bispecific antibody, and use thereof. The anti-CD40 antibody comprises a heavy chain variable region and a light chain variable region. The heavy chain variable region comprises the HCDR1, HCDR2 and HCDR3 in SEQ ID NO: 64. The light chain variable region comprises the LCDR1, LCDR2 and LCDR3 in SEQ ID NO: 65. The novel anti-CD40 agonistic antibody of the present invention can effectively regulate and control the activation of DC cells, has a stronger T cell activation effect while having low toxic and side effects, and is suitable for immunotherapy of tumors. The bispecific antibody of the present invention can maximize the anti-tumor drug effect, improve the selectivity of CD40 activation by means of PD-L1-dependent CD40 activation, and lower the toxic and side effects of the CD40 agonistic antibody.