Abstract: The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and a method of identifying a compound that modulates intracellular signaling of an Fc receptor. DNA constructs, cells, and kits relating to these assays are also disclosed.

Abstract: The disclosure provides a tetravalent Dengue virus vaccine, and methods of inducing a immune response against a Flavivirus such as Dengue virus 1-4 using the vaccine. The disclosure also provides methods of making a vaccine by introducing into a host cell a transgene that encodes a protein comprising Dengue domain III polypeptides, or, by purified dill polypeptides specific for Dengue serotypes 1-4, Yellow Fever Virus, West Nile Virus, Japanese Encephalitis Virus, and Flaviviruses.

Abstract: A system which may enable users to plan, design and observe various building systems in an abstract and intuitive view, such as with a map view. In this view, virtually all facility information and objects may be displayed as simple shapes (e.g., rectangles). Just by some drag-and-drop, a user may provide shapes and rearrange positions of these shapes quickly to reflect a desired space relationship. Objects (e.g., components, devices, controllers, and the like) may be placed, moved around, and associated with each other on a facility layer or floor. Further, the map view may be used together with a tree view and a list view to provide alternative design ways. Changes made in any of the views may be synchronized with the other views. Various presentations of the facility may be provided.

Abstract: The present invention relates to a method of interfering with dengue infection comprising interfering with dengue virus binding to a syndecan present on a cell targeted by dengue virus. The present invention further relates to treating a patient for dengue virus infection comprising administering to a patient, either having a dengue infection or a patient exposed to dengue infection, an effective amount of an agent that interferes with dengue virus binding to a syndecan on a surface of a cell targeted by dengue virus. The present invention further relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier, and an effective amount of an agent that interferes with dengue virus binding to a syndecan on a surface of a cell targeted by dengue virus.

Abstract: A method and system for modeling a three-dimensional smoke propagation animation system. The animation system can be configured to include a particle system manager, a compartment manager, a state variable manager, a three-dimensional space outline rendering module, and a three-dimensional smoke animation rendering module. The particle system manager creates and updates an existing particle system based on an input script and data from the state variable manager. The state variable manager loads smoke propagation data and provides smoke information to the particle system manager to create and update the particle system and space outline. The compartment manager creates a three-dimensional outline with respect to each compartment space from a compartment data and updates the status of the existing three-dimensional outlines based on information from the state variable manager. A final three-dimensional smoke propagation animation can then be rendered by the three-dimensional smoke animation rendering module.

Abstract: A shoulder mounted hood cooling assembly includes a support, a blower carried by the support, and vents in fluid communication with the blower. The support when worn by a user positions at least a portion of the support adjacent the user's shoulder's and the vents are positioned to direct air exhausted from the blower to a neck or to a head or both the neck and the head of the user.

Abstract: A method of controlling a cursor displayed on a display device is provided. A three-dimensional environment is displayed on a display device. A cursor and a plurality of objects are displayed on the display device within the three-dimensional environment. The cursor comprises a zone defining a volume to identify at least one object that is at least partially located within the volume. The size of the volumetric activation zone is dynamically adjusted so that a predetermined constraint is satisfied. The predetermined constraint is a function of at least a relationship between the volumetric activation zone of the cursor and at least one of the plurality of objects.

Abstract: A shoulder mounted hood cooling assembly includes a support, a blower carried by the support, and vents in fluid communication with the blower. The support when worn by a user positions at least a portion of the support adjacent the user's shoulder's and the vents are positioned to direct air exhausted from the blower to a neck or to a head or both the neck and the head of the user.

Abstract: A system which may enable users to plan, design and observe various building systems in an abstract and intuitive view, such as with a map view. In this view, virtually all facility information and objects may be displayed as simple shapes (e.g., rectangles). Just by some drag-and-drop, a user may provide shapes and rearrange positions of these shapes quickly to reflect a desired space relationship. Objects (e.g., components, devices, controllers, and the like) may be placed, moved around, and associated with each other on a facility layer or floor. Further, the map view may be used together with a tree view and a list view to provide alternative design ways. Changes made in any of the views may be synchronized with the other views. Various presentations of the facility may be provided.

Abstract: A method and system for modeling a three-dimensional smoke propagation animation system. The animation system can be configured to include a particle system manager, a compartment manager, a state variable manager, a three-dimensional space outline rendering module, and a three-dimensional smoke animation rendering module. The particle system manager creates and updates an existing particle system based on an input script and data from the state variable manager. The state variable manager loads smoke propagation data and provides smoke information to the particle system manager to create and update the particle system and space outline. The compartment manager creates a three-dimensional outline with respect to each compartment space from a compartment data and updates the status of the existing three-dimensional outlines based on information from the state variable manager. A final three-dimensional smoke propagation animation can then be rendered by the three-dimensional smoke animation rendering module.

Abstract: The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and a method of identifying a compound that modulates intracellular signaling of an Fc receptor. DNA constructs, cells, and kits relating to these assays are also disclosed.

Abstract: Disclosed are methods and compositions related to determining the status and mechanisms underlying long-term nonprogression of viral infections.

Abstract: A method of controlling a cursor displayed on a display device is provided. A three-dimensional environment is displayed on a display device. A cursor and a plurality of objects are displayed on the display device within the three-dimensional environment. The cursor comprises a zone defining a volume to identify at least one object that is at least partially located within the volume. The size of the volumetric activation zone is dynamically adjusted so that a predetermined constraint is satisfied.

Abstract: A method (20) for selectively deleting messages received by a radio telephone (1). The method (20) includes detecting when the telephone (1) has moved from a previous coverage area to a current coverage area and selectively obtaining a set of coverage area specific messages (Mset) stored in a memory (16,18) associated with the telephone (1), the coverage area specific messages being from a set of messages received when the telephone was in the previous coverage area. The method (1) provides for and automatically deleting the coverage area specific messages from the memory (16,18) when the telephone (1) is in the current coverage area.