Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5?)ppp(5?)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Abstract: The communication receiver comprises a mixer being configured to mix the communication signal with a periodic mixing signal having a mixing frequency fC to obtain a mixed communication signal, wherein the mixed communication signal comprises a first frequency spectrum portion comprising the spectral region of interest being situated around a frequency fRF+fC and a second frequency spectrum portion comprising the spectral range of interest being situated around fRF?fC; a first demodulator being configured to demodulate a first frequency channel of the plurality of frequency channels within the spectral range of interest of the first frequency spectrum portion on the basis of a first local oscillator frequency fLO1; and a second demodulator being configured to demodulate a second frequency channel of the plurality of frequency channels within the spectral region of interest of the second frequency spectrum portion on the basis of a second local oscillator frequency fLO2.

Abstract: Compositions and methods for delivering therapeutic compounds to the brain are provided.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: A sheetfed film scanning correction method includes: using a film holding member as a film feeding carrier, wherein the film holding member is fixed and does not move during film feeding, and wherein after the film holding member is inserted into a work position in a scanner, a scanning module of the scanner collects a first correction information under a filmless scanning state and corrects a subsequent scan result according to the first correction information; and setting sheet-feeding rollers of the scanner in idle running as if under a real film scanning state during or prior to collection of the first correction information.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: A scan assisting fixing device and a scanner using the same are provided. The fixing device is for fixing an object to be scanned, which includes a scanning portion and a holding portion. The fixing device includes an accommodation region, a scan window and a protrusion portion. When the holding portion is loaded in the accommodation region, the scanning portion correspondingly disposed in the scan window is retained and fixed by the protrusion portion, and the position of the holding portion in the fixing device is constant, so that the scanning portion is always within the range of the field depth of the scanner regardless of the specification of the positive film holder, and the clarity of the scanned image is assured.

Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.

Abstract: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: An automatic transmission for an electric vehicle hub includes an external motor rotor fixedly connected with a motor shaft; a sun gear; at least three first planet gears; and at least three second planet gears coaxially fixed with the corresponding first planet gears and which are engaged with the sun gear. The first and the second planet gears are respectively engaged with first and second internal gears, and the second internal gear has a diameter greater than that of the first internal gear. The rotating disk is arranged between the first internal gear and the second internal gear, and a hub is fixed to exterior of the rotating disk. The automatic transmission further includes a clutch device, making the rotating disk and the first internal gear contact with each other for a transmission of slower rpm, and when the rpm reaches critical, at a high-speed rotation.

Abstract: A scan assisting fixing device and a scanner using the same are provided. The fixing device is for fixing an object to be scanned, which includes a scanning portion and a holding portion. The fixing device includes an accommodation region, a scan window and a protrusion portion. When the holding portion is loaded in the accommodation region, the scanning portion correspondingly disposed in the scan window is retained and fixed by the protrusion portion, and the position of the holding portion in the fixing device is constant, so that the scanning portion is always within the range of the field depth of the scanner regardless of the specification of the positive film holder, and the clarity of the scanned image is assured.

Abstract: The present invention is to provide a massager moves on a pair of undulated tracks. The massager comprises a massaging core 1, and a base 2, which includes a tow unit 3, a shank 4, a pair of tracks 51 and a pair of undulated tracks 52. The tow unit 3 is slided along the tracks 51, the tow unit is connected to the massaging core 1 by a pivotal axle. And the massaging core 1 is further guided to move along the undulated tracks 52. Tow unit 3 meshed with the shank 4 can be driven by a driving unit and a transmission unit, thereby, the tow unit 3 can be glided along the shank 4 and the track 51. The massaging core 1 connected to a tow unit 3 can slide along a pair of undulated tracks similar to waist, back, and neck portions of human body.