Abstract: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: The invention relates to a lighting structure and a scanning device. The lighting structure comprises a light source and a light guide. The light source comprises a plurality of light emitters spaced within a first plane along a first direction. The light guide comprises a plurality of light guiding bodies arranged in parallel. The light guiding bodies form a one-to-one correspondence with the light emitters and have a light entering surface and a light leaving surface which are both a curved surface. The curve of the intersection between each light leaving surface and a first cross-section has a first curvature radius, and the curve of the intersection between each light entering surface and a second cross-section has a second curvature radius, wherein the first cross-section is perpendicular to the second cross-section, and the first cross-section and the second cross-section are both perpendicular to the first plane.

Abstract: A sheetfed film scanning correction method includes: using a film holding member as a film feeding carrier, wherein after the film holding member is inserted into a work position in a scanner, a scanning module of the scanner collects a first correction information under a filmless scanning state and corrects a subsequent scan result according to the first correction information; and setting sheet-feeding rollers of the scanner in idle running as if under a real film scanning state during or prior to collection of the first correction information. By film scanning simulation, the backlight distribution information under the filmless state is real-time collected and used as a correction information, hence implementing the collection of most accurate scan correction information as if under a real scanning environment, particularly applicable to the portable sheetfed film scanner, and eliminating impacts on the correction information caused by temperature change or physical vibration.

Abstract: A scanning device and a scanning method thereof are provided. The scanning device includes a scanning group, a paper-feed roller and a calibration portion. The scanning group includes a line light source generating module and a scanning module. The line light source generating module includes a point light source, a light-guiding plate and a casing. The light emitted by the point light source along a first direction is converted into a line light source through a light-guiding plate disposed in the casing. The light emitted by the line light source along a second direction is emitted from an opening of the casing. The scanning module, along the first direction, includes a scan document region and a calibration region. The light reflected through the to-be-scanned document is received in the scan document region. The calibration portion disposed on the casing or the paper-feed roller corresponds to the calibration region.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.

Abstract: The present invention provides compounds having formula I: and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.

Abstract: The present invention provides an enantiomerically pure compound of Formula I: along with pharmaceutical formulations containing the same and methods of use thereof.

Abstract: The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: An automatic transmission for an electric vehicle hub includes an external motor rotor fixedly connected with a motor shaft; a sun gear; at least three primary planet gears which are engaged with the sun gear; and at least three secondary planet gears coaxially fixed with the primary planet gears. The primary and the secondary planet gears are engaged with a primary and a secondary internal gears, and the secondary internal gear has a diameter greater than that of the primary internal gear. The rotating disk is arranged between the primary internal gear and the secondary internal gear, and a hub is fixed to exterior of the rotating disk. The automatic transmission further includes a clutch device, making the rotating disk and the primary internal gear contact with each other for a transmission of slower rpm, and when the rpm reaches critical, at a high-speed rotation.

Abstract: The present invention is to provide a massager moves on a pair of undulated tracks. The massager comprises a massaging core 1, and a base 2, which includes a tow unit 3, a shank 4, a pair of tracks 51 and a pair of undulated tracks 52. The tow unit 3 is slided along the tracks 51, the tow unit is connected to the massaging core 1 by a pivotal axle. And the massaging core 1 is further guided to move along the undulated tracks 52. Tow unit 3 meshed with the shank 4 can be driven by a driving unit and a transmission unit, thereby, the tow unit 3 can be glided along the shank 4 and the track 51. The massaging core 1 connected to a tow unit 3 can slide along a pair of undulated tracks similar to waist, back, and neck portions of human body.

Abstract: Shift gears of a variable speed motor is no longer needed for a set of gears, but multiple layers disks with magnets fit over an axle rotated by a multiple layers annular opening of a housing, where winding coils wound along inside each annulus seperately. When electrifying each winding coils on each annulus, each corresponding disk can rotate the axle at a fixed ratio to output an extreme high speed or a high torque at low or moderate speed. Such disks and annuli are arranged according to their decrement diameters from the opening to a top of the housing; thereby, each disk is corresponding to each annulus with winding coils in one-to-one relationship. However, magnets disposed to a perimeter of each disk, which is made from magnetic insulation material, such as aluminum alloys, to avoid from interference among each disk.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases.

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally

Abstract: The present invention provides compounds having formula I: and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation.

Abstract: A scan system and a scanning method are provided, The scan system is for scanning a transparent document. The scan system includes a backlight module, an optical module and a control unit. The backlight module has several light sources. The transparent document is disposed between the backlight module and the optical module. The optical module is capable of moving with respect to the transparent document and the backlight module for capturing the image of the transparent document. The control unit controls the backlight module to turn on at least parts of the light sources. When the optical module moves with respect to the transparent document to several positions at different time points, parts of the light sources corresponding to the positions are sequentially turned on. The light emitted by the light sources is projected into the optical module after passing through the transparent document.