Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image, signals during scanning a region of interest.

Abstract: A system-on-chip imaging system includes an image sensor of a two-dimensional array of pixel elements providing pixel data representing an image of a scene, a data memory for storing pixel codewords whereby at least some of the pixel codewords are indicative of the pixel data, a programmable lookup table for providing LUT codewords as output data, and a processing unit for receiving LUT codewords from the lookup table and generating output image data. In operation, a first pixel codeword stored in the data memory is used to index the lookup table for causing the lookup table to provide a respective LUT codeword to the processing unit. The processing unit operates to perform one or more image processing functions in response to the LUT codeword. The lookup table can be programmed to perform a variety of image processing functions, including defective pixel correction, CDS subtraction, privacy masking and dark signal subtraction.

Abstract: Techniques pertaining to a circuit architecture capable of controlling a current source to a predefined precision are disclosed. According to one aspect of the present invention, an automatic trimming circuit is proposed to automatically trim a current generated from a current generator or circuit in accordance with a reference current. The automatic trimming circuit includes a comparator, an ADC and a register. The comparator that may be implemented as a subtractor finds a difference between a generated current and a reference current. The difference is then digitized to an n-bit precision. A digital representation of the difference is then kept in a register and used subsequently correct or modify the generated current to produce a precisely controlled current.

Abstract: Architecture of an integrated image sensor is disclosed. The image sensor includes an interface to transport image data out of the sensor directly to a host computing device. To accommodate the required data transfer speed, a raw image (e.g., a Bayer pattern image) from the sensor is directly digitized, compressed if the resolution thereof exceeds a range, and output via the interface. A color image of the scene is reconstructed from the raw image in the host computing device.

Abstract: Antibodies which specifically recognize the human CD45 isoform RB are presented. These antibodies may be used to block undesirable immune reactions in patients with transplant rejection and autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and autoimmune diabetes. Preferred antibodies are fully human, monoclonal antibodies.

Abstract: Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

Abstract: A method and an apparatus for examining the subsurface microstructure of a sample are provided. Radiation from a plurality of optical radiation sources travels along a first optical path. In the first optical path, a device focuses the optical radiati n from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within the selected length extending into the sample is scanned along said selected portion of the first optical path.

Abstract: This invention provides methods for determining or predicting response to cancer therapy in an individual.

Abstract: In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

Abstract: Antibodies directed to the antigen CD20 and uses of such antibodies are disclosed herein. In particular, fully human monoclonal antibodies directed to the antigen CD20. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.

Abstract: The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

Abstract: In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

Abstract: The present invention is related to antibodies directed to the antigen properdin and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen properdin. Nucleotide sequences encoding, and polypeptides comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: An image sensor includes a sensor or a pixel array, a data memory, and a logic circuit, all fabricated on the same integrated chip. The sensor or pixel array outputs digital signals as pixel data representing an image of a scene. The data memory is coupled to the sensor or pixel array for storing the pixel data. The logic circuit is coupled to the data memory and provides a memory interface for exporting the pixel data. The memory interface can be one of a SRAM, a DRAM or a packet protocol synchronous DRAM interface. Including a memory interface in the image sensor allows the image sensor to be coupled directly to the memory interface port of an external image processing unit. The image processing unit can access the image sensor using conventional memory access protocols, thus improving the efficiency and reducing the operational complexity of the image processing unit.

Abstract: An architecture for a digital pixel sensor is disclosed in which the dynamic range of the sensor is increased by taking samples of a subject to be recorded, where each sample is taken over an interval of a different duration than the other samples. In the preferred embodiment of the invention, an array of pixel elements is fabricated in an integrated circuit. Each of the pixel elements outputs a digital signal and comprises a photodetector and an analog to digital converter. The photodetector is integrated with the analog to digital converter. An array of threshold memory cells, each corresponding to one of the pixel elements, is also provided. An array of time memory cells, each corresponding to one of the pixel elements, establishes a different sampling time for each of the pixel elements for each of multiple samples. An array of memory elements, each coupled to one of the pixel elements, is also provided. The memory elements are also fabricated in the integrated circuit.

Abstract: An image sensor includes a sensor array including a two-dimensional array of pixel elements. The array of pixel elements includes a first group of photodetectors having a first sensitivity level and a second group of photodetectors having a second sensitivity level. The sensor array outputs digital signals as pixel data representing an image of a scene. In operation, the first group of photodetectors generates the output signals after a first exposure time and the second group of photodetectors generates the output signals after a second exposure time, where the first exposure time and the second exposure time are within a snapshot of the scene and the first exposure time is different than the second exposure time. When thus operated, the image sensor of the present invention provides improved color reproduction capability and improved signal to noise ratio, especially for the less sensitive photosensitive elements.

Abstract: An improved technique for updating a memory in digital pixel sensors in which a memory update may be directed to only some of the locations or cells in the memory is disclosed. According to one embodiment, a multiplex scheme is employed, in which a threshold memory identifies the locations within a row of memory that are to be updated. Data are first read out of a row of memory to be updated. The data are copied to a first buffer or other short term storage area within the digital pixel sensor. New data from the sensor portion of the digital pixel sensor to be written to the memory are stored in a second buffer. The contents of the threshold memory are then applied to a select input of a multiplexer, where the contents of the first and second buffers comprise first and second data inputs to the multiplexer. Thus, the output of the multiplexer comprises an updated row of memory in which only those locations that are to be updated have been changed.