Abstract: The invention relates to medical therapy using an agonist of the retinoic acid receptor-related orphan receptor gamma (ROR?) and provides adoptive cellular therapies using an agonist of ROR?, populations of lymphocyte cells that have been exposed to an agonist of ROR?, populations of dendritic cells that have been exposed to an agonist of ROR?, pharmaceutical compositions, and methods for enhancing therapeutic effects of lymphocyte cells and/or dendritic cells in a patient by administering an agonist of ROR? to a patient.

Abstract: The present invention provides a draw solute for forward osmosis comprising a carbon dioxide responsive structural unit and a thermally responsive structural unit, wherein the draw solute is capable of reversibly switching between a protonated state and a deprotonated state. The present invention also provides a forward osmosis method utilising the draw solute.

Abstract: A system for controlling an unmanned aerial vehicle (UAV) to switch between different flight modes during operation. The system includes one or more processors configured to determine, based on sensor data received from one or more sensors carried by the UAV, a change in environment of the UAV from a first environment type to a second environment type. In response to determining the change in environment, the one or more processors configured to switch a flight mode of the UAV from a first flight mode to a second flight mode, and effect operation of the UAV in accordance with a second set of operating rules for operating in the second environment type.

Abstract: Disclosed are systems, methods, and computer-readable storage media for adaptive load balancing for application chains. A load-balancer can receive a data packet for a connection/transaction to be routed through an application chain. The load-balancer can select, based on an application path table, a first end-to-end application path through the application chain. The application path table can identify two or more end-to-end application paths through the application chain along with a corresponding performance status for each end-to-end application path through the application chain. The performance status for an application path can indicate a performance level of the end-to-end application path determined based on performance of previous data packets for previous connections transmitted through the application chain according to the end-to-end application path.

Abstract: A system includes a host processor (105) and a peripheral device (708). The host processor (105) is coupled to the peripheral device (708) by a Peripheral Component Interconnect Express (PCIe) compliant link. The peripheral device (708) can include logic circuitry to identify, based on an application using the device and the host processor (105), a read to write ratio utilized by the application; and provide the read to write ratio to the host processor (105). The host processor (105) comprising logic circuitry to send a command signal to a device in communication with the hardware processor across a peripheral component interconnect express (PCIe) compliant link, the command signal indicating a transmission (TX) lane to receive (RX) lane ratio, the TX lane to RX lane ratio corresponding to the read to write ratio identified by the peripheral device (708); and receive an indication that the device is capable of supporting asymmetric TX and RX ratios.

Abstract: A magnesium alloy cast-rolling unit, including: a main body; a fluid supplier; an electric pushrod; a linkage mechanism; a horizontal platform; a screw; dovetail guide rails; and a bottom plate. The main body includes a base, a spring cylinder, a hydraulic adjustment cylinder, a connection portion, and a cast-rolling unit body. The connection portion includes an arc-shaped rail. The spring cylinder includes an actuation element. The actuation element includes a piston rod and a pressure strip. The piston rod includes an external thread at one end; and the pressure strip includes an internal thread corresponding to the external thread. The fluid supplier includes a head box, a corrugated pipe, a compression spring assembly including a gland cover, a connection pipe including a convex pipe joint and a concave pipe joint, a flat plate including a groove, a smelting furnace, and a horizontal operation platform.

Abstract: An integrated circuit (IC) structure includes an active area of the IC structure insulator positioned over a substrate. The active area includes an interconnection structure comprised of a first plurality of levels. Each of the interconnect structure levels including an interlayer dielectric (ILD) layer, a barrier layer disposed over the ILD and a conductor metal layer over the barrier layer. The structure also includes a crack stop area which includes a crack stop structure having a second plurality of levels. The interconnect and crack stop structures have an equal number of levels. A third plurality of the crack stop structure levels include a high modulus layer unique to the respective crack stop structure level as compared to the corresponding interconnect structure level. In another aspect of the invention, a method for fabricating the structure is described.

Abstract: An integrated circuit (IC) structure includes an active area of the IC structure insulator positioned over a substrate. The active area includes an interconnection structure comprised of a plurality of levels, each of the interconnect structure levels including an interlayer dielectric (ILD) layer, a barrier layer disposed over the ILD and a conductor metal layer over the barrier layer. The IC structure also includes a crack stop area which includes a crack stop structure having an equal plurality of levels as the interconnect structure. Each of the crack stop structure levels includes at least one of the layers of the interconnection structure at a same level. At least one crack stop structure level also includes a high modulus layer unique to the crack stop structure level as compared to the corresponding interconnect structure level. In another aspect of the invention, a method for producing the structure is described.

Abstract: A magnesium alloy cast-rolling unit, including: a main body; a fluid supplier; an electric pushrod; a linkage mechanism; a horizontal platform; a screw; dovetail guide rails; and a bottom plate. The main body includes a base, a spring cylinder, a hydraulic adjustment cylinder, a connection portion, and a cast-rolling unit body. The connection portion includes an arc-shaped rail. The spring cylinder includes an actuation element. The actuation element includes a piston rod and a pressure strip. The piston rod includes an external thread at one end; and the pressure strip includes an internal thread corresponding to the external thread. The fluid supplier includes a head box, a corrugated pipe, a compression spring assembly including a gland cover, a connection pipe including a convex pipe joint and a concave pipe joint, a flat plate including a groove, a smelting furnace, and a horizontal operation platform.

Abstract: A non-destructive testing method of analyzing a sample comprising a composite material is disclosed. The method comprises: emitting an electromagnetic signal onto the sample, the electromagnetic signal having a range of frequencies; detecting a response signal transmitted and/or reflected by the sample in response to the electromagnetic signal; processing the response signal to determine variation with frequency of a dielectric permittivity of the sample over the range of frequencies; and determining an indication of a structural characteristic of the sample from a measure of the variation with frequency of the dielectric permittivity of the sample.

Abstract: Variety of approaches to optimize performance based on behavioral and situational signals are described. A productivity service initiates operations to optimize performance upon receiving a behavioral signal and/or a situational signal associated with a user. The behavioral signal and/or the situational signal are analyzed to infer a usage pattern associated with a component of an application. Next, a failure of the usage pattern is detected in a comparison to an utility threshold. In response, the application is instructed to interrupt an execution of the component.

Abstract: An integrated circuit (IC) structure includes an active area of the IC structure insulator positioned over a substrate. The active area includes an interconnection structure comprised of a first plurality of levels. Each of the interconnect structure levels including an interlayer dielectric (ILD) layer, a barrier layer disposed over the ILD and a conductor metal layer over the barrier layer. The structure also includes a crack stop area which includes a crack stop structure having a second plurality of levels. The interconnect and crack stop structures have an equal number of levels. A third plurality of the crack stop structure levels include a high modulus layer unique to the respective crack stop structure level as compared to the corresponding interconnect structure level. In another aspect of the invention, a method for fabricating the structure is described.

Abstract: An integrated circuit (IC) structure includes an active area of the IC structure insulator positioned over a substrate. The active area includes an interconnection structure comprised of a plurality of levels, each of the interconnect structure levels including an interlayer dielectric (ILD) layer, a barrier layer disposed over the ILD and a conductor metal layer over the barrier layer. The IC structure also includes a crack stop area which includes a crack stop structure having an equal plurality of levels as the interconnect structure. Each of the crack stop structure levels includes at least one of the layers of the interconnection structure at a same level. At least one crack stop structure level also includes a high modulus layer unique to the crack stop structure level as compared to the corresponding interconnect structure level. In another aspect of the invention, a method for producing the structure is described.

Abstract: A system for controlling an unmanned aerial vehicle (UAV) includes one or more processors configured to receive sensor data from one or more sensors carried by the UAV. The sensor data is indicative of at least a state of the UAV. The one or more processors are further configured to select a flight mode from a plurality of different flight modes based at least in part on the sensor data and effect operation of the UAV in accordance with a set of operating rules associated with the selected flight mode.

Abstract: A method of determining a flight path for an aerial vehicle includes identifying during flight a change in a state of signal transmission occurring at a first location, and, in response to identifying the change, selecting a first destination within a proximity of a second location. A state of signal transmission at the second location during a previous flight is different from a state of signal transmission at the first location. The method further includes determining a first flight path to reach the first destination. The first flight path comprises accessible locations detected by one or more sensors onboard one or more aerial vehicles. The method also includes, upon reaching the first destination by the aerial vehicle, assessing in real time a state of signal transmission at the first destination, and determining a second flight path to a second destination based on the assessment.

Abstract: The present disclosure is related to a non-volatile thermotropic composite material comprising a first component comprising a non-aqueous and non-volatile proton donating material; a second component comprising a monomer, an oligomer or a polymer as a proton accepting material; a non-volatile polymeric matrix; and wherein the non-volatile polymeric matric, the first component and the second component are configured to maintain at least one property which is reversibly changeable based on thermal energy received by or given out from the non-volatile thermotropic composite material. Proton donating materials include ionic liquid, poly(ionic liquid) and deep eutectic salt. The proton accepting material comprises at least an ether, a phenyl ester, an amide and an acrylate functional group.

Abstract: Stress generation free thru-silicon-via structures with improved performance and reliability and methods of manufacture are provided. The method includes forming a first conductive diffusion barrier liner on an insulator layer within a thru-silicon-via of a wafer material. The method further includes forming a stress absorption layer on the first conductive diffusion barrier. The method further includes forming a second conductive diffusion barrier on the stress absorption layer. The method further includes forming a copper plate on the second conductive diffusion barrier.

Abstract: Aspects include a method of manufacturing a flexible electronic structure that includes a metal or doped silicon substrate. Aspects include depositing an insulating layer on a silicon substrate. Aspects also include patterning a metal on a silicon substrate. Aspects also include selectively masking the structure to expose the metal and a portion of the silicon substrate. Aspects also include depositing a conductive layer including a conductive metal on the structure. Aspects also include plating the conductive material on the structure. Aspects also include spalling the structure.

Abstract: A method for controlling flight of an aircraft includes obtaining a location of a target area in an image captured by an imaging device mounted on the aircraft. The method also includes determining, based on the location of the target area, a relative direction of a target object corresponding to the target area relative to the aircraft. The method also includes determining a first direction of the aircraft based on the relative direction, the first direction being a direction approaching the target object. The method also includes based on a determination that the aircraft is in a moving-away flight mode, determining a second direction based on the first direction, the second direction being opposite the first direction. The method further includes controlling the flight of the aircraft based on the second direction.