Abstract: A traffic data stream aggregate query method and system includes the steps of acquiring spatial-temporal information of a mobile object to generate a traffic data stream, dividing data space into cells, grouping adjacent cells with similar frequency into few buckets, calculating Kalman gains of the buckets based on frequencies of the buckets, and indexing the buckets using a binary partition tree to form a BPT index of the current timestamp, and serializing the BPT after the end of the current timestamp to form a historical index; and performing aggregate query, wherein an optimum estimation value of the bucket frequency is utilized to replace for calculating when the frequency of the bucket changes a lot. The system includes: an information collection module, a data processing module, an index processing module, an application service module and an index storage module.

Abstract: A method of determining a beating parameter of cells that undergo excitation contraction coupling, the method including providing a cell analysis device having a substrate and a sensor that measures cell adhesion or attachment to the substrate in millisecond time resolution; adding excitable cells capable of undergoing excitation contraction coupling to the substrate; monitoring cell adhesion or attachment of the excitable cells to the substrate in millisecond time resolution; and calculating one or more beating parameters from the monitored adhesion.

Abstract: Systems and methods for improved monitoring of excitation-contraction coupling and excitable cells are provided, which provide millisecond time resolution. The system is capable of continuously monitoring excitation-contraction coupling in a relatively high-throughput manner. The system includes a device for monitoring cell-substrate impedance, an impedance analyzer capable of impedance measurements at millisecond time resolution, electronic circuitry that can engage the device and selectively connect two or more electrode arrays of the device to the impedance analyzer and a software program that controls the electronic circuitry and records and analyzes data obtained from the impedance analyzer.

Abstract: Techniques and configurations for establishing cross-domain communications between a business application, a third party website or service, and mashup components of a mashup user interface are generally described herein. In one example embodiment, a scripting library which establishes socket connections between domains and between components of a common mashup user interface is included or referenced in a mashup component and in a third party component that are displayed in the common browser-based mashup user interface. A scripting library executing in the browser may be used to establish and control the socket connections that communicate changes to the business application data, transmitted from the third party webpage to the mashup. The changes to the business application data, communicated and received in front-end objects, then may be processed or further communicated for persistence at the business application.

Abstract: Disclosed are a method and a device for processing live video. The method for processing live video includes: receiving, by a CDN server, a request for playing video sent from a player, wherein a video format supported by the player and identification information of the requested video are carried in the request; obtaining an access path of the requested video according to the identification information of the requested video; obtaining the requested video from a resource server corresponding to the access path; converting a format of the requested video to the video format supported by the player; and sending the player the requested video which can be played on the player.

Abstract: Disclosed are a method, an electronic device and a system for slicing a streaming media file. At a control center, the method includes: scheduling a slicing task onto a master server to execute the slicing task; and scheduling the slicing task being executed by the master server onto a backup server to continue executing if the master server stops slicing. At a backup server, the method includes: receiving a scheduling instruction sent by a control center, wherein the scheduling instruction is used for instructing the backup server to continue executing a slicing task being executed on a master server; and continuing executing the slicing task scheduled from the master server in response to the scheduling instruction.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

Abstract: The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays.

Abstract: A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.

Abstract: The present invention relates to a method and a device for deep oil removal from wastewater containing a low concentration of wasteoil. Wastewater containing a low concentration of wasteoil enters the device via an inlet and passes through a flow conditioner, causing the fluid to become uniformly distributed. Then, by means of a layer of oleophilic-hydrophobic fibers and hydrophilic-oleophobic fibers woven in a certain manner, a trace of oil droplets are captured and then coalesce and grow on the layer, and a trace of oil-in-water emulsion is demulsified and separated on the layer. Finally, by means of corrugation-enhanced sedimentation and separation, the oil droplets coalesce and grow and are then separated rapidly. The invention also provides a set of devices for implementing the method, having several parts such as a housing, a feed pipe, a flow conditioner, a fiber coalescence layer, a corrugation-enhanced separation layer, and a level gauge.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways.

Abstract: Technical solutions for managing business application life cycle with multi-tasking ability are provided. In some implementations, a method includes: at an enterprise data processing application: (A) activating a first application page, which includes: loading a first data set from a first data source, and causing the first data set to be displayed on the first application page; (B) switching from the first application page to a second application page, by: deactivating, without closing, the first application page, including: causing the first data set to be stored in a temporary storage; and activating a second application page; and (C) switching from the second application page back to the first application page, by: deactivating, without closing, the second application page; and re-activating the first application page, including: loading the first data set from the temporary storage, and causing the first data set to be displayed on the first application page.

Abstract: A method and apparatus for optimizing target error rates for link adaptation in a communication system. The method includes estimating a data rate associated with transmission of a data stream over a communication link. A required target error rate is then selected from a plurality of pre-defined target error rate values based on whether the estimated data rate is within a range of at least one of a plurality of pre-defined threshold values, where each of the pre-defined target error rate values maps to one of the plurality of pre-defined threshold values. A link adaptation parameter associated with the communication link is then selected or updated to maintain the required target error rate and the data stream is transmitted over the communication link using the selected/updated link adaptation parameter.

Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

Abstract: An information collection module receives an incident report request from a user of a browser running a network application on a client system to thereby provide a page in the browser. The information collection module collects incident data including user interactions with the page, client system features and operations associated with executing the network application, and a document object model (DOM) of the page. An annotation tool of the network application receives annotations of the page from the user for inclusion in the incident data, and a server-side incident manager receives the incident data. The server-side incident manager includes a rendering engine that renders the document object model and the annotations, and an incident analyzer that displays the collected user interactions, and client system features and operations, and the rendered document object model and annotations.

Abstract: Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described.

Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

Abstract: A method of performing an assay of a response of two or more cell types to a test compound, including: providing a device for monitoring cell-substrate impedance, adding at least two different cell types to the device; adding at least one test compound to form at least two test compound wells; providing at least two control wells; monitoring impedance of the at least two test compound wells and of the at least two control wells at three or more time points after adding the at least one test compound; and analyzing measured impedance from the at least two test compound wells and from the at least two control wells at the three or more time points to obtain information on the response of the different cell types to the at least one test compound.

Abstract: A method for value-added usage of process-oriented extension fields in business mashups may include generating, using at least one processor, a mashup component with an unbound parameter; receiving input identifying the creation of an extension field, the extension field tied to data stored in a database; binding the unbound parameter of the mashup component to the extension field; presenting an application interface, the application interface including the extension field; receiving a request to load the mashup component; and in response to receiving the request, passing the data tied to the extension field as an input parameter to the mashup component.

Abstract: Iterating an optical phase conjugation of ultrasonically-modulated diffuse light emitted by a scattering medium includes illuminating the scattering medium with a light beam from a coherent light source, modulating the diffuse light transmitted through the scattering medium with an ultrasonic wave focused on a region of interest within the scattering medium, fixing a hologram, retro-reflectively illuminating the scattering medium using a phase-conjugated copy of the diffuse light that was ultrasonically modulated, moving the ultrasonic focus, and iterating until light is focused on the final target.