Abstract: Provided herein, inter alia, are compounds, pharmaceutical compositions and methods related to the treatment of viral infections caused by coronavirus or enterovirus. Provided herein are compounds of Formula (I), (II) and (III) and methods of using the compounds for therapy. These compounds are peptidomimetics that inhibit protease 3CL of a coronavirus, and are useful for treating conditions caused by viral infections, including COVID-19.

Abstract: A bias circuit includes a mirror current source and a current-to-voltage converter. A first terminal of the mirror current source is connected to a supply voltage terminal, a second terminal of the mirror current source is connected to a reference voltage terminal, and a third terminal of the mirror current source is connected to the current-to-voltage converter. A mirror current source is configured to acquire a supply voltage transmitted at the supply voltage terminal through the first terminal, acquire a reference voltage transmitted at the reference voltage terminal through the second terminal, and regulate the supply voltage by using the reference voltage and a preset parameter to obtain a mirror current corresponding to the supply voltage. The preset parameter is parameter information of the mirror current source. The current-to-voltage converter is configured to convert the mirror current into a voltage to provide a bias voltage based on the voltage.

Abstract: A permanent magnet alloy according to the present disclosure contains Mn at a content not lower than 41% by atom and not higher than 53% by atom; Al at a content not lower than 46% by atom and not higher than 53% by atom; and Cu at a content not lower than 0.5% by atom and not higher than 10% by atom. The alloy contains a stable phase, having a tetragonal structure, at a ratio not lower than 50%.

Abstract: The present invention relates to methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

Abstract: A method for monitoring a cell beating parameter, which includes adding excitable cells capable of beating to a system for monitoring cell-substrate impedance, the system having an electrode array electrically coupled to an impedance analyzer that measures cell-substrate impedance at millisecond time resolution, and a software program that determines a cell beating parameter from measured cell-substrate impedance; monitoring cell-substrate impedance of the excitable cells; and determining the cell beating parameter from the monitored cell-substrate impedance.

Abstract: This disclosure relates to modified interleukin 2 (IL-2) polypeptides, polynucleotides, e.g., DNA, RNA or viral vector, that encode the modified IL-2 polypeptides and are configured to express said modified IL-2 polypeptides in vitro and/or in vivo, conjugates comprising the modified IL-2 polypeptides, and uses thereof.

Abstract: A system for monitoring cell-substrate impedance of excitable cells at millisecond time resolution and methods of assessing cell beating by monitoring cell-substrate impedance of beating cells at millisecond time resolution.

Abstract: Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.

Abstract: An ion implantation system, ion source, and method are provided, where an ion source is configured to ionize an aluminum-based ion source material and to form an ion beam and a by-product including a non-conducting material. An etchant gas mixture has a predetermined concentration of fluorine and a noble gas that is in fluid communication with the ion source. The predetermined concentration of fluorine is associated with a predetermined health safety level, such as approximately a 20% maximum concentration of fluorine. The etchant gas mixture can have a co-gas with a concentration less than approximately 5% of argon. The aluminum-based ion source material can be a ceramic member, such as a repeller shaft, a shield, or other member within the ion source.

Abstract: An electrical connecting plate, a battery module, a battery pack, and a device are discoursed, which relate to the technical field of energy storage devices. The electrical connecting plate includes a first part and a second part. The first part includes a current-increasing portion and a body portion containing an avoidance region. The current-increasing portion is located in a specified region around the avoidance region. The current-increasing portion is connected to a side of the body portion in a thickness direction of the electrical connecting plate. The second part is connected to ends of the body portion and is configured to connect to a battery cell. The battery module includes a plurality of battery cells and the electrical connecting plate. The second part of the electrical connecting plate electrically connects electrode leads of a plurality of battery cells.

Abstract: Methods for managing a robot arm are disclosed. In one method, during a movement of the robot arm in an axis thereof, a signal collected by a sensor equipped at a frame of the robot arm is received. A change in strength of the received signal is detected, where the change is caused by an offset between a position of a reference mark equipped at the robot arm and a position of the sensor. An original point of the axis of the robot arm is determined based on the detected change. Further, robot systems, apparatuses, systems, and computer readable media for managing a robot arm in the robot systems are disclosed. The original point of the axis of the robot arm may be determined without a dedicated calibrating tool, and then the robot arm may be calibrated based on the original point accurately.

Abstract: A method of assessing cytolysis of cancer cells, the method including: providing a cell substrate impedance monitoring cartridge having a plurality of chambers, each chamber having an electrode array configured for measuring cell-substrate impedance, wherein different chambers are preloaded with different target cells embodied as cancer cells of different lineage, origin or stage; adding effector cells to the plurality chambers for interaction with the target cells, wherein the effector cells are immune cells; monitoring cell-substrate impedance of the plurality of chambers before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedances; and determining effectiveness of effector cell killing of the different target cells by comparing the impedances or impedance-based parameters over time.

Abstract: Embodiments herein are directed to a system that includes a user interface and a vehicle. The vehicle includes an electronic control unit communicatively coupled to the user interface. The electronic control unit includes one or more processors, one or more memory modules, and machine readable instructions stored in the one or more memory modules that cause the electronic control unit to perform at least the following: transmit a plurality of vehicle security options to the user interface, the plurality of vehicle security options selectable by a user to actuate one or more of the security components of the vehicle security system, receive an input from the user interface indicative of at least one selected option of the plurality of vehicle security options to be actuated, and enable the security system with the at least one selected option to be actuated when the vehicle security system is activated.

Abstract: A super-tough steel and a production method thereof. The present invention belongs to the field of steels and preparation thereof, and particularly relates to a super-tough steel for cryogenic services, and a production method thereof. The super-tough steel comprises the following elements in percentage by weight: 0.10% to 0.15% of C, and 29.5% to 31.5% of Mn, with the balance being Fe and inevitable impurities. The production method comprises the following steps: A1, smelting with argon protection, and electroslag remelting; A2, hot rolling or hot forging; A, annealing at 900° C. to 1100° C. for 1 hour, and quenching; and A4, cold rolling, annealing of the cold-rolled plate at 700° C.-1200° C. for 1 hour, and quenching after annealing. The steel is simple in composition and does not contain precious metals; and the steel has an average grain size of less than 30 microns, and is non-magnetic with complete face-centered cubic structure.

Abstract: Disclosed methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC AND TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

Abstract: An information processing method comprising: obtaining environment information of a video file in a preview state, where the preview state is a display state before the video file is played; in response to the environment information satisfying a first pre-set condition, indicating the video file by a first cover; and in response to the environment information satisfying a second pre-set condition, indicating the video file by a second cover.

Abstract: The present disclosure provides a method for knocking out an N-myristoyltransferase (NMT) gene from Eimeria tenella, and belongs to the technical field of microorganisms. The method includes: mixing sporozoites of Eimeria tenella with a pCRISPR::EtNMT plasmid and a pEtNMT::DHFR plasmid, and subjecting a resulting mixture to electrotransformation to obtain NMT gene-knockout Eimeria tenella. The method provided by the present disclosure can successfully knock out the NMT gene from Eimeria tenella, which lays a foundation for studying the function of the Eimeria tenella gene and developing a vaccine therefor.

Abstract: A system for monitoring cell-substrate impedance of excitable cells at millisecond time resolution and methods of assessing cell beating by monitoring cell-substrate impedance of beating cells at millisecond time resolution.

Abstract: A composition for planarizing a semiconductor device surface includes a catalyst, at least one solvent, and at least one polysiloxane resin including polysilsesquioxane blocks and polydisiloxane blocks. The polydisiloxane blocks are according to the general formula: wherein R1, R2 are each independently selected from the group consisting of: an aryl group or an alkyl group, with substituted or unsubstituted carbons.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.