Abstract: An information processing method comprising: obtaining environment information of a video file in a preview state, where the preview state is a display state before the video file is played; in response to the environment information satisfying a first pre-set condition, indicating the video file by a first cover; and in response to the environment information satisfying a second pre-set condition, indicating the video file by a second cover.

Abstract: A ball screw spline assembly includes: a ball screw spline including a first nut including a first mounting surface adapted to receive a first fastening element for installing the first nut to a housing; a second nut including a second mounting surface adapted to receive a second fastening element for installing the second nut to the housing; and a shaft passing through the first nut and the second nut; the housing including a first portion and a second portion, the first portion extends in a direction substantially parallel to the shaft, and the second portion extends in a direction substantially perpendicular to the shaft; a connecting plate coupling the second nut to the first portion, the first nut is installed to the second portion; the first mounting surface and the second mounting surface are located within a space defined by the first portion, the second portion and the connecting plate, such that the ball screw spline is integrally installable to the housing.

Abstract: Extracellular recording devices with reference electrodes positioned in a cell free zone and methods of conducting extracellular recording. Parallel cell-substrate impedance monitoring and extracellular recording of excitable cells such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells using devices that switch between extracellular recording and impedance monitoring modes.

Abstract: A method of identifying a therapeutic compound for treating cancer in a human subject, the method including: providing a device that measures cell-substrate impedance; culturing cancer cells in the at least two wells, wherein the cancer cells are obtained from a human subject and have a receptor tyrosine kinase (RTK) pathway; adding to a first well a proposed therapeutic compound that affects an RTK pathway and an RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells; and determining a difference in impedance or optionally in cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells of the human subject.

Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.

Abstract: Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.

Abstract: Apparatus and methods are described for adapting a programming environment to handle renamed programming constructs such as classes and packages. Non-canonical identifiers that reference renamed programming constructs can be used in code parts to be executed in the programming environment, and the code parts can execute, without disruption or user intervention, using related canonical identifiers. The solutions described herein provide backward and forward compatibility for code and data affected by renaming of programming constructs.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

Abstract: Methods of identifying whether a biologically active agent affects an oncogene addicted pathway within a cancer cell, by introducing a biologically active agent suspected of affecting an oncogene addicted pathway to a first well and a negative control to a second well, and introducing a stimulating agent that stimulates the oncogene addicted pathway to both wells; monitoring cell-substrate impedance of the two wells and optionally determining cell indices from impedance values; generating an impedance based curve for each of the two wells from the impedance values or from the cell indices; comparing the impedance-based curves to determine a degree of similarity; and if significantly different concluding the biologically active agent affects the oncogene addicted pathway within the cancer cells.

Abstract: The present invention discloses a machining technology of a low-temperature high-strength-ductility high manganese steel, high manganese steel plate, and high manganese steel tube, and a high manganese steel comprises the following components in percentage by weight: Mn 30%-36%, C 0.02%-0.06%, S?0.01%, P?0.008% and the balance being Fe. Smelted steel ingots are subject to solution treatment and are rolled and homogenized to obtain a high manganese steel plate or are drawn to form a high manganese steel tube. The hot-rolled or cold-rolled steel plate after being hot-rolled has tremendous application value in the fields of low-temperature applications, such as the steel plate used for a low temperature pressure container.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways.

Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

Abstract: A traffic data stream aggregate query method and system includes the steps of acquiring spatial-temporal information of a mobile object to generate a traffic data stream, dividing data space into cells, grouping adjacent cells with similar frequency into few buckets, calculating Kalman gains of the buckets based on frequencies of the buckets, and indexing the buckets using a binary partition tree to form a BPT index of the current timestamp, and serializing the BPT after the end of the current timestamp to form a historical index; and performing aggregate query, wherein an optimum estimation value of the bucket frequency is utilized to replace for calculating when the frequency of the bucket changes a lot. The system includes: an information collection module, a data processing module, an index processing module, an application service module and an index storage module.

Abstract: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.

Abstract: A composition for planarizing a semiconductor device surface includes poly(methyl silsesquioxane) resin, at least one of a quaternary ammonium salt and an aminopropyltriethoxysilane salt, and at least one solvent. The poly(methyl silsesquioxane) resin ranges from 1 wt. % to 40 wt. % of the composition. The poly(methyl silsesquioxane) resin has a weight average molecular weight between 500 Da and 5,000 Da. The at least one of the quaternary ammonium salt and the aminopropyltriethoxysilane salt ranges from 0.01 wt. % to 0.20 wt. % of the composition. The at least one solvent comprises the balance of the composition.

Abstract: Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.

Abstract: Provided are methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

Abstract: A system for monitoring cell-substrate impedance of excitable cells and monitoring the beating cycle of cardiomyocytes, the system including: a device for monitoring cell-substrate impedance at 20 millisecond time resolution, the device having one or more wells on a nonconductive substrate, wherein at least one well of the one or more wells comprises an electrode array fabricated on the substrate for measurement of cell-substrate impedance at 20 millisecond time resolution; an impedance analyzer that measures cell-substrate impedance from the at least one well at 20 millisecond time resolution; electronic circuitry that electrically connects the electrode array from the at least one well to the impedance analyzer; and a software program that analyzes the measured cell-substrate impedance.

Abstract: An action corrections system includes an interface and a processor. The interface is configured to receive generic data and proprietary data. The processor is configured to determine a generic data entity; match the generic data entity to a proprietary data entity to form a joined entity; determine a response variable from the proprietary data; determine a need for action corrections in regards to the joined entity based at least in part on the response variable; and determine one or more action corrections in regards to the joined entity.

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.