Abstract: The present invention discloses a display panel. The display panel includes a touch electrode area. The touch electrode area includes a first touch circuit layer and a second touch circuit layer corresponding to the first touch circuit layer. Wherein the first touch circuit layer is electrically connected to the second touch circuit layer, and the first touch circuit layer and the second touch circuit layer completely coincide with each other in a direction perpendicular to the display panel.

Abstract: In some embodiments, a first detector generates a first output based on a first probability that an image was inserted in a video. The first detector is trained with a set of known images to detect the set of known images. A second detector generates a second output based on a second probability that an image was inserted in the video. The second detector is used to detect the set of unknown images without training. The method analyzes the first output from the first detector based on the probability of the image existing in the video and the second output from the second detector based on the probability of the image existing in the video to generate a combined score from the first output and the second output. An indication of whether the image is detected in the video is output based on the combined score.

Abstract: A partial pressure tool for real-time measurement and adjustment of pressure and viscosity and a measurement method thereof. The partial pressure tool includes an outer cylinder and adjustable annular throttling grooves, and the adjustable annular throttling grooves are split-type grooves vertically and successively installed on an inner wall of the outer cylinder at equal intervals. Four single throttling grooves are adjacent to each other and arranged concentrically on a circumferential surface. A viscometer is installed on a surface of an arc-shaped inner plate in a tail-end adjustable annular throttling groove. The viscometer is connected to an induction board through a transmission line. The arc-shaped inner plate in the tail-end adjustable annular throttling groove is provided with a pressure sensor and a torque sensor, and the pressure sensor and the torque sensor both are connected to the induction board. The induction board is connected to a DSP control module.

Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.

Abstract: A method for generating a UAV flight trajectory. The method includes acquiring map data of a to-be-reconstructed area; the map data includes a satellite map image and a plane map image; acquiring building silhouettes of each building in a to-be-reconstructed area from a plane map image; acquiring height data of each building from a satellite map image; generating an initial model according to the building silhouettes and height data of each building; determining a view set according to an initial model; generating a flight trajectory from a view set. The initial model can be established without pre-flight of the to-be-reconstructed area, and the UAV flight trajectory can be directly generated, so that the calculation amount of data is reduced.

Abstract: Disclosed are an intermediate of a pyrrolo six-membered heteroaromatic ring derivative as a JAK inhibitor and a preparation method therefor, and a method for preparing a pyrrolo six-membered heteroaromatic ring derivative using the intermediate. The method improves the reaction yield, is simple and easy to operate and control, and is conducive to expanded industrial production.

Abstract: Disclosed herein are compounds capable of inducing apoptosis through promoting Nur77 interaction with Bcl-2 and through modulating mitochondrial activities. Also disclosed herein are compositions and methods using these compounds and compositions. Nur77 is a key regulator of Bcl-2 activities and is capable of converting Bcl-2 from an anti-apoptotic protein to a pro-apoptotic protein. Small molecules that directly modulate the Nur77/Bc1-2 apoptotic pathways are promising for treating diseases with abnormal levels of Bcl-2, Nur77, or combinations thereof, including cancers.

Abstract: A method and system are described for hydrocarbon exploration, development and production. The method relates to performing regression and/or classification in subsurface models to support decision making for hydrocarbon operations. The evaluation may then be used in performing hydrocarbon operations, such as hydrocarbon exploration, hydrocarbon development and/or hydrocarbon production.

Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.

Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.

Abstract: The present disclosure relates to systems and methods for providing online to offline services. The systems and methods may obtain a plurality of historical positions of a user terminal within a first predetermined time period in a plurality of days. The systems and methods may identify at least one candidate area based on the plurality of historical positions of the user terminal. The systems and methods may identify one or more of the at least one candidate areas as one or more active areas of the user terminal. The systems and methods may further provide data associated with one or more service requests relating to the one or more active areas to a customer application executed by the user terminal.

Abstract: The present disclosure provides a flat panel detection substrate, a fabricating method thereof and a flat panel detector. The flat panel detection substrate according to the present disclosure includes a base substrate; a bias electrode and a sense electrode on the base substrate; and a semiconductor layer over the bias electrode and the sense electrode, the semiconductor layer having a thickness greater than 100 nm.

Abstract: The present invention belongs to the technical field of biological pharmacy, and particularly relates to a long-acting HM-3 fusion protein molecule and an application thereof. In the present invention, on the basis of the sequence of HM-3 molecule, an active polypeptide HM-3 and derivatives thereof are linked to a human Fc (IgG) fragment or a fragment of an Fc (IgG) mutant directly or by a linker peptide (Linker), thus forming a novel molecular entity. The general formula of the molecular entity is (HM-3)n-Linker-Fc(IgG), Fc(IgG)-Linker-(HM-3)n, or (HM-3)n-Linker-Fc(IgG)-Linker-(HM-3)n. The fusion protein effectively prolongs the half-life of HM-3, is low in cost and overcomes the major problem of druggability of small peptides. Therefore, the fusion protein of the present invention may serve as a potential drug for the treatment of autoimmune diseases, neovascular diseases, osteoarthritis and the like.

Abstract: The present disclosure discloses an optical imaging lens group including, sequentially from an object side to an image side along an optical axis, a first lens, a second lens, a third lens, a fourth lens, a fifth lens and a sixth lens, each of which has refractive power. An object-side surface of the first lens is a convex surface, and an image-side surface of the first lens is a concave surface; an image-side surface of the second lens is a concave surface; and an object-side surface of sixth lens is a concave surface. A distance TTL along the optical axis from an object-side surface of the first lens to an imaging plane of the optical imaging lens group and half of a diagonal length ImgH of an effective pixel area on the imaging plane of the optical imaging lens group satisfy TTL/ImgH?1.23.

Abstract: An optical imaging lens includes a first lens element, a second lens element, a third lens element, and a fourth lens element from an object side to an image side in order along an optical axis. The first lens element to the fourth lens element each include an object-side surface facing the object side and allowing imaging rays to pass through and an image-side surface facing the image side and allowing the imaging rays to pass through. The object-side surface of the second lens element has a concave portion in a vicinity of the optical axis. The image-side surface of the second lens element has a convex portion in a vicinity of a periphery of the second lens element. The object-side surface of the third lens element has a concave portion in a vicinity of a periphery of the third lens element. The fourth lens element has negative refracting power.

Abstract: A mobile CBCT imaging system is constructed on a mobile base. A scanning ring having an x-ray source, one or more curved detectors each with a curved grid, is connected to the mobile base. The scanning ring is configured to be spatially positioned as desired by an operator. The source is configured to revolve about an imaging axis and to emit radiographic energy toward the imaging axis.

Abstract: A headset for experiencing an augmented and/or a virtual reality environment may include a housing defining an interior cavity, with optical components received in the interior cavity of the housing. A front face may be rotatably coupled to a front portion of the housing to selectively enclose the interior of the housing. A computing device including a display may be received in a slot defined between the front portion of the housing and the front face. A face pad may be removably coupled to the housing, opposite the front face, so as to enclose the optical components in the housing. A user may view an augmented/virtual reality environment displayed on the display through the optical components received in the housing. An adjustable head strap assembly may adjustably position the headset on the head of the user.

Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.

Abstract: Corneal stromal scars are the leading cause of corneal blindness. The present invention relates to methods and compositions useful in therapies for this pathological condition. The invention provides corneal stromal stem cells and certain other stem cells and as well as exosome polynucleotides produced by such cells, and methods for making and using these cells and compositions. The invention is based upon the discovery that exosomes and their associate active components obtained from these cells comprise agents having the same capacity as corneal stromal stem cells to reduce scarring and prevent scar formation in patients having corneal damage.

Abstract: A method for preparing a label-free aptamer electrochemical sensor of ?-interferon based on a dendrimer/gold nanoparticle/molybdenum disulfide nanocomposite is provided. The nanocomposite is drip-coated on a surface of an electrode to prepare a modified electrode, and a terminal sulfhydryl group of a ?-interferon aptamer chain is connected to the gold nanoparticle via Au—S bond to obtain a nanocomposite-aptamer modified electrode. When ?-interferon is present, the ?-interferon specifically binds to the aptamer chain on the sensor, resulting in the aptamer's hairpin structure being opened and stretched, which can effectively adsorb methylene blue MB in the electrolyte, causing significant enhancement of MB redox signal. A linear relationship between a current intensity of MB oxidation peak and a concentration of the ?-interferon is fitted to construct the label-free aptamer electrochemical sensor of ?-interferon.