Abstract: The invention describes fully native human neutralizing monoclonal antibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonal antibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and detection of Clostridium tetani infection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as possessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.

Abstract: Disclosed are a pharmaceutical composition and an application thereof. The pharmaceutical composition of the present invention comprises the following components in parts by weight: 2-20 parts of phenolic acids, 0.5-5 parts of flavonoids, 0.005-0.5 part of tanshinones, 5-20 parts of saponins, and 10-18 parts of volatile oils. The pharmaceutical composition has the functions of protecting against myocardial damage and treating heart failure.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A detection panel and a detection device are provided. The detection panel includes: a base substrate, a photoelectric conversion layer and a first insulating layer which are sequentially stacked on the base substrate; wherein the detection panel further comprises a plurality of interdigital electrodes located on a surface of a side of the first insulating layer away from the base substrate.

Abstract: Application discloses a picture encoding method and a terminal. In the method, a terminal divides the plurality of pictures into N groups, wherein the dividing is based on reference information of each of a plurality of pictures. The terminal encodes the N groups of pictures, where the following steps are performed on each one of the N groups of pictures: selecting a first picture from a target group according to a preset rule, and encoding the first picture, where the first picture is a picture first encoded in the target group, and the target group is any one of the N groups of pictures; selecting a reference picture for a second picture from the target group, where the second picture is a picture in the target group other than the first picture; and performing motion estimation on the second picture by using the reference picture, to encode the second picture.

Abstract: The present disclosure discloses a three-dimensional topographic mapping system and mapping method. The system includes: a floating platform, a detection apparatus, and a ground apparatus, where the floating platform is located in the stratosphere above a predetermined ground area that is to be mapped; the detection apparatus is arranged on the floating platform and configured to map the predetermined ground area according to mapping instruction information transmitted by the ground apparatus, and return mapping data to the ground apparatus; and the ground apparatus processes the returned mapping data to obtain DEM data. In the three-dimensional topographic mapping system according to embodiments of the present disclosure, the detection apparatus is arranged on the floating platform to map the predetermined ground area and cooperate with the ground apparatus to calculate the mapping data.

Abstract: A method for preparing a label-free aptamer electrochemical sensor of ?-interferon based on a dendrimer/gold nanoparticle/molybdenum disulfide nanocomposite is provided. The nanocomposite is drip-coated on a surface of an electrode to prepare a modified electrode, and a terminal sulfhydryl group of a ?-interferon aptamer chain is connected to the gold nanoparticle via Au—S bond to obtain a nanocomposite-aptamer modified electrode. When ?-interferon is present, the ?-interferon specifically binds to the aptamer chain on the sensor, resulting in the aptamer's hairpin structure being opened and stretched, which can effectively adsorb methylene blue MB in the electrolyte, causing significant enhancement of MB redox signal. A linear relationship between a current intensity of MB oxidation peak and a concentration of the ?-interferon is fitted to construct the label-free aptamer electrochemical sensor of ?-interferon.

Abstract: A method for migration of data is provided. The method includes triggering a rebuild of data according to a first migration mechanism from a first storage drive to a second storage drive. Monitoring space utilization associated with the second storage drive, and adaptively switching the migration of the data from the first migration mechanism to a second migration mechanism based on the monitoring.

Abstract: The present disclosure provides an MEMS microphone including a base having a rear cavity and a capacitor system disposed on the base. The capacitor system includes a rear plate and a diaphragm that are spaced relatively apart to form an acoustic cavity. A piezoelectric diaphragm is attached to a side of the diaphragm, the side being away from the acoustic cavity. The piezoelectric diaphragm, under the deformation effect of the diaphragm, deforms to generate and output charges. Therefore, the MEMS microphone can output two groups of electrical signals, one group of electrical signals output by the capacitor system and one group of electrical signals output by the piezoelectric diaphragm, thereby sensitivity of the microphone is improved.

Abstract: The present invention discloses a display panel. The display panel includes a touch electrode area. The touch electrode area includes a first touch circuit layer and a second touch circuit layer corresponding to the first touch circuit layer. Wherein the first touch circuit layer is electrically connected to the second touch circuit layer, and the first touch circuit layer and the second touch circuit layer completely coincide with each other in a direction perpendicular to the display panel.

Abstract: Provided is a piezoelectric type and capacitive type combined MEMS microphone, comprising a base with a back cavity and a capacitor system arranged on the base; wherein, the capacitor system comprises a back plate and a diaphragm; the back plate is opposite to and apart from the diaphragm to form a first sound cavity; a piezoelectric diaphragm structure is between the capacitor system and the base; a second sound cavity is formed between the capacitor system and the piezoelectric diaphragm structure; the second sound cavity is at least in communication with the first sound cavity or the back cavity; the piezoelectric type and capacitive type combined MEMS microphone can output two groups of electric signals comprising a group of electric signals output from the capacitor system and a group of electric signals output from the piezoelectric diaphragm structure, thus improving sensitivity of the microphone.

Abstract: Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R1 is —H, —OH, —F, —Cl, —Br, —I, —OCH3, —OCF3, —OCHF2, —OCH2F, —CF3, —CHF2, —CH2F, —CH3, —CH3CH2, —CF3CH2, —CN, —NO2, —NH2 or —COOR5; R2 is H, C1-C10 linear alkyl, C3-C10 branched alkyl, C3-C10 cyclic alkyl, C1-C10 hydroxyalkyl or a N-substituted piperazine-derived group; or R2 is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.

Abstract: Systems and methods are disclosed for estimating aesthetic quality of digital images using deep learning. In particular, the disclosed systems and methods describe training a neural network to generate an aesthetic quality score digital images. In particular, the neural network includes a training structure that compares relative rankings of pairs of training images to accurately predict a relative ranking of a digital image. Additionally, in training the neural network, an image rating system can utilize content-aware and user-aware sampling techniques to identify pairs of training images that have similar content and/or that have been rated by the same or different users. Using content-aware and user-aware sampling techniques, the neural network can be trained to accurately predict aesthetic quality ratings that reflect subjective opinions of most users as well as provide aesthetic scores for digital images that represent the wide spectrum of aesthetic preferences of various users.

Abstract: A system includes reception of a first request from a client application to create an application runtime associated with a tenant of the client application, creation, in response to the first request, of metadata describing configuration information of the application runtime, reception of a second request from the client application to start a session of the application runtime, starting, in response to the second request, of a first application runtime instance in a first container of a first virtual machine based on the configuration information of the application runtime, and return of first connection information to the client application, the first connection information usable by the client application to communicate with the first application runtime instance.

Abstract: The present invention provides a compound having the following structure: Compositions and methods for using the same in the treatment of skin disorders and other Pim kinase-associated conditions are also disclosed.

Abstract: The invention provides a continuous-wave pumped polymer laser and preparation method thereof, comprising: coating an organic polymer solution onto a substrate to form an polymer film, and applying a template having a distributed feedback structure to the polymer film, or coating an organic polymer solution onto a substrate having a distributed feedback structure to form an polymer film, and applying a plate to the polymer film; heating the substrate to reach above the phase transition temperature of the organic polymer, and applying a pressure to the template or plate for 1-100 min; and cooling the substrate to reach below the phase transition temperature of the organic polymer, and removing the template or plate from the organic polymer. The method of the invention is simple, the organic polymer molecular chain and supramolecular structure are oriented to have long range order, and the obtained laser can use continuous-wave pumping.

Abstract: The present disclosure discloses an engineering strain and application thereof in joint production of Danshensu and alanine, and belongs to the technical field of bioengineering. The present disclosure constructs a three-enzyme co-expression genetic engineering strain, and realizes joint production of Danshensu and alanine. Further, the transport of a substrate is promoted and decomposition of products is reduced by knocking out or enhancing expression of related genes on E. coli genome. The genetic engineering strain provided by the present disclosure can produce optically pure D-danshensu and L-danshensu, and jointly produce pyruvic acid. The production process is simple, raw materials are easily available, impurities are fewer, and a good industrial application prospect is achieved.

Abstract: A method and system for configuring regenerative braking energy recovery devices in urban rail transit provided by the present application, successively including the following steps: calculating a preliminarily configured capacity Pn of a regenerative braking energy recovery device predetermined for the traction substation n, then obtaining an optimally configured capacity Qn of the regenerative braking energy recovery devices; further, configuring the total number of the regenerative braking energy recovery devices; finally, configuring the type of the regenerative braking energy recovery devices. By reasonably configure the capacity and number of regenerative braking energy recovery devices in traction substations, the configuring method of the present application allows the regenerative braking energy generated by a train during braking to be completely absorbed, thus reduce the energy consumption of braking resistors.

Abstract: Methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including Crohn's disease are provided. Also provided are methods of administering and dosing integrin beta7 antagonists, such as anti-integrin beta7 antibodies. In addition, methods of administrating and dosing such integrin beta7 antagonists to induce remission or to induce and maintain remission of Crohn's disease are provided.

Abstract: In some embodiments, a method detects a first set of frames in a video that include lines of text, the detecting performed at a frame level on each individual frame. A first representation is generated from the first set of frames and a second representation is generated from the first set of frames. The method filters the first representation based on a number of lines of text within a space in the space dimension to select a second set of frames and filters the second representation based on a number of frames within time intervals in the time dimension to select a third set of frames. Frames in both the second set of frames and the third set of frames are analyzed to determine whether the lines of text in both the second set of frames and the third set of frames are burned-in subtitles.