Patents by Inventor Xiaojun Liu

Xiaojun Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11047156
    Abstract: According to one aspect of the invention, a latch is configured to fix a panel relative to a frame. The latch includes a housing configured for engagement to the panel. The latch also includes a cap mounted within the housing and a shaft extending along a longitudinal axis within the housing. A spring of the latch is configured to bias the shaft away from the cap along the longitudinal axis, and a sleeve of the latch interposed between the shaft and the housing, the sleeve defining a first slot. The latch also includes a cam interposed between the shaft and the housing, the cam defining a second slot. A pin is provided which extends into the first and second slots. The first and second slots are configured to guide the rotation and axial movement of the shaft as the cap is rotated within the housing.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: June 29, 2021
    Assignee: Southco, Inc.
    Inventors: Xiaojun Liu, Richard B. Langkamp, Jr., Hailu Wang
  • Publication number: 20210176476
    Abstract: A video encoding method is provided in the present invention. The method includes: determining a range of interest ROI in an ith frame, wherein the ROI comprises at least one ROI macroblock; extracting characteristic information of the at least one ROI macroblock, wherein the characteristic information comprises location information and type information of the at least one ROI macroblock; determining a quantization parameter QP corresponding to each of the at least one ROI macroblock; encoding the characteristic information of the at least one ROI macroblock according to the determined QP corresponding to each ROI macroblock, to obtain an ROI characteristic stream of the ith frame; and adding, to a video stream of the ith frame, the QP corresponding to each ROI macroblock and the ROI characteristic stream of the ith frame, to perform sending, wherein the video stream of the ith frame is obtained by encoding the ROI and a non-ROI comprised in the ith frame.
    Type: Application
    Filed: January 26, 2021
    Publication date: June 10, 2021
    Inventors: Minsheng WANG, Maojian XIANG, Xiaojun LIU
  • Patent number: 11028143
    Abstract: The invention provides T cells comprising nucleic acid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell priming, compositions including the T cells, and methods of using the T cells to treat diseases associated with the expression of disease-associated antigens.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: June 8, 2021
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Devon J. Shedlock, Carl H. June, Xiaojun Liu
  • Publication number: 20210155667
    Abstract: The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 27, 2021
    Inventors: Yangbing Zhao, Xiaojun Liu, Wei Pan
  • Publication number: 20210137980
    Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.
    Type: Application
    Filed: March 5, 2020
    Publication date: May 13, 2021
    Inventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
  • Patent number: 10961687
    Abstract: A silt filtering device includes a moving bottom plate. A first material conveying water pump, a stirring box, a filter box and a compression box are sequentially arranged on an upper portion of the moving bottom plate. A roller mechanism is arranged on each of four diagonal portions of a lower portion of the moving bottom plate. A controller, an infrared sensor and a high-definition camera assembly are arranged on the upper portion of the moving bottom plate. The first material conveying water pump conveys silt material to the stirring box through a convey pipe. A jitter mechanism assembly is arranged at a bottom portion of the stirring box to generate jittering. The jitter mechanism assembly comprises a plurality of identically shaking spring bodies and a driving cylinder arranged on the shaking spring bodies.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: March 30, 2021
    Inventor: Xiaojun Liu
  • Patent number: 10939126
    Abstract: A video encoding method is provided in the present invention. The method includes: determining a range of interest ROI in an ith frame, wherein the ROI comprises at least one ROI macroblock; extracting characteristic information of the at least one ROI macroblock, wherein the characteristic information comprises location information and type information of the at least one ROI macroblock; determining a quantization parameter QP corresponding to each of the at least one ROI macroblock; encoding the characteristic information of the at least one ROI macroblock according to the determined QP corresponding to each ROI macroblock, to obtain an ROI characteristic stream of the ith frame; and adding, to a video stream of the ith frame, the QP corresponding to each ROI macroblock and the ROI characteristic stream of the ith frame, to perform sending, wherein the video stream of the ith frame is obtained by encoding the ROI and a non-ROI comprised in the ith frame.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: March 2, 2021
    Assignee: GUANGZHOU ZHIJING TECHNOLOGY CO., LTD
    Inventors: Minsheng Wang, Maojian Xiang, Xiaojun Liu
  • Patent number: 10934336
    Abstract: The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: March 2, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Xiaojun Liu, Wei Pan
  • Publication number: 20210040234
    Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof.
    Type: Application
    Filed: June 24, 2020
    Publication date: February 11, 2021
    Inventors: Carl H. June, Yangbing Zhao, Xiaojun Liu
  • Publication number: 20210008188
    Abstract: The present invention includes compositions and methods for modifying a T cell with a nucleic acid encoding a switch molecule comprising an extracellular domain comprising a membrane receptor or fragment thereof and an intracellular domain comprising a signaling receptor or fragment thereof. In one aspect, a method comprises introducing a nucleic acid encoding a switch molecule and a nucleic acid encoding a soluble fusion protein and/or a nucleic acid encoding a bispecific antibody into a population of cells comprising T cells, wherein the T cells transiently expresses the switch molecule and soluble fusion protein or bispecific antibody. In other aspect, compositions of T cells and methods of treating a disease or condition, such as cancer or an autoimmune disease, are also included.
    Type: Application
    Filed: September 30, 2020
    Publication date: January 14, 2021
    Inventors: Yangbing Zhao, Carl H. June, Xiaojun Liu
  • Publication number: 20200407728
    Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.
    Type: Application
    Filed: July 30, 2020
    Publication date: December 31, 2020
    Inventors: Yangbing Zhao, Jiangtao Ren, Xiaojun Liu, Carl H. June
  • Patent number: 10828353
    Abstract: The present invention includes compositions and methods for modifying a T cell with a nucleic acid encoding a switch molecule comprising an extracellular domain comprising a membrane receptor or fragment thereof and an intracellular domain comprising a signaling receptor or fragment thereof. In one aspect, a method comprises introducing a nucleic acid encoding a switch molecule and a nucleic acid encoding a soluble fusion protein and/or a nucleic acid encoding a bispecific antibody into a population of cells comprising T cells, wherein the T cells transiently expresses the switch molecule and soluble fusion protein or bispecific antibody. In other aspect, compositions of T cells and methods of treating a disease or condition, such as cancer or an autoimmune disease, are also included.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: November 10, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Carl H. June, Xiaojun Liu
  • Patent number: 10834247
    Abstract: A mobile terminal with unlock function is provided.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: November 10, 2020
    Inventors: Minsheng Wang, Xiaojun Liu
  • Publication number: 20200345778
    Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Inventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
  • Patent number: 10803129
    Abstract: The present disclosure relates to a method for processing online user distribution. The method includes acquiring a map for displaying online user distribution; determining the projection algorithm of the map; determining intermediate coordinates of at least one of the points according to a longitude and a latitude and the projection algorithm, and acquiring, by using a fitting algorithm, approximate solutions of functions of mapping the intermediate coordinates to the coordinates on the map. The method further includes calculating coordinates of each online user on the map according to the projection algorithm and the approximate solutions of the mapping functions; and assembling distribution data of online users on the map according to coordinates of all the online users on the map. The present disclosure further provides an apparatus for processing online user distribution.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: October 13, 2020
    Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventors: Qidong Zhuang, Junhong Tu, Xiaojun Liu, Jie Yang, Ming Rao, Nan Qin
  • Patent number: 10780120
    Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: September 22, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
  • Patent number: 10760748
    Abstract: A high environmental protective and energy-saving LED illumination lamp includes a base, a first lamp body assembly arranged on an upper portion of the base, and a second lamp body assembly arranged on an upper portion of the first lamp body assembly. A controller, a power supply, a data memory, a wireless communication transmission unit configured to communicate with an external mobile terminal, an alerter configured to generate an alarm sound in case of an emergency, a sound device, and a voltage stabilizer are arranged inside the base. A first rotary drive motor is arranged inside the base. A rotary disc configured to support the first lamp body assembly is arranged between the base and the first lamp body assembly. The first rotary drive motor drives the rotary disc to rotate to drive the first lamp body assembly to rotate synchronously.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: September 1, 2020
    Inventor: Xiaojun Liu
  • Publication number: 20200209172
    Abstract: An X-ray inspection device for a drone includes: a suspension device provided in the drone; an X-ray generator device for a drone, the X-ray generator device being movable up and down by the suspension device and including an X-ray source that emits an X-ray toward an object to be inspected; and a detector that is movable up and down by the suspension device and detects the X-ray transmitted through the object to be inspected.
    Type: Application
    Filed: December 23, 2019
    Publication date: July 2, 2020
    Applicant: TSUKUBA TECHNOLOGY CO., LTD.
    Inventors: Bo Wang, Norio Saito, Shuichi Suzuki, Xiaojun Liu, Wenkang Guo
  • Patent number: 10696749
    Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 30, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Yangbing Zhao, Xiaojun Liu
  • Publication number: 20200204672
    Abstract: A mobile terminal with unlock function is provided.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 25, 2020
    Inventors: Minsheng WANG, Xiaojun LIU