Abstract: The present disclosure provides modified immune cell (e.g., modified T cell) comprising an exogenous T cell receptor (TCR) having specificity for NY-ESO-1. The present disclosure provides modified immune cells or precursors thereof (e.g., modified T cells) comprising an exogenous TCR and a switch receptor. Gene edited modified cells are also provided, such that the expression of one or more of an endogenous T-cell receptor gene (e.g., TRAC, TRBC) or an endogenous immune checkpoint gene (e.g. PD-1 or TIM-3) is downregulated.

Abstract: A sewage treatment system includes a main box and a can-type filter arranged on a side of the main box. A power source, a controller, a data memory, a temperature and humidity sensor, a wireless communication transmission unit, a BLUETOOTH transmission unit and an alertor are arranged inside the main box. The data memory, the temperature and humidity sensor, the wireless communication transmission unit, the BLUETOOTH transmission unit, and the alertor are electrically connected with the controller. The main box is externally connected with a conveying pipeline to convey the sewage into an interior of the main box. A primary filter, a secondary filter and a tertiary filter are sequentially arranged in an interior of the main box from top to bottom.

Abstract: A sewage treatment device includes a stirring structure, a filter box, a tank filter, and a detection structure which are connected in sequence. Conveying pipelines are connected to an exterior of the stirring structure to convey sewage to an interior of the stirring structure. First water pumps are connected to the conveying pipelines to provide conveying power. An upper-layer stirrer assembly, a lower-layer stirrer assembly and a rotating shaft configured to install the upper-layer stirrer assembly and the lower-layer stirrer assembly are arranged in the interior of the stirring structure. A lifting driving cylinder drives the upper-layer stirrer assembly and the lower-layer stirrer assembly to move up and down. The upper-layer stirrer assembly includes an engaging block axially engaged with the rotating shaft and stirring blades arranged around the periphery of the engaging block at equal intervals.

Abstract: A municipal garden sweeper includes a mobile frame, a control box arranged on an upper portion of the mobile frame, a first exhaust pipe, and a second exhaust pipe arranged on left and right sides of the control box. The first exhaust pipe and the second exhaust pipe are configured to suck up and collect external garbage. A first exhaust fan is arranged on a connecting portion of the first exhaust pipe and the control box. A second exhaust fan is arranged on a connecting portion of the second exhaust pipe and the control box. The first exhaust fan and the second exhaust fan are configured to respectively provide power for the first exhaust pipe and the second exhaust pipe to suck up the external garbage.

Abstract: A water conserving reaming system includes a water storage box, a water pumping pipe communicated with the water storage box, a first lifting platform, a second lifting platform, a reaming mechanism assembly, and a reamer bit connected with a front end of the reaming mechanism assembly. The first lifting platform includes a first base, a lifting frame arranged on an upper portion of the first base and a pipeline joint. An end of the water pumping pipe extends into the water storage box. An other end of the water pumping pipe is communicated with a bottom portion of the first base. A filtering mechanism for performing primary filtering treatment on a water source from the water pumping pipe is arranged inside the first base. The second lifting platform includes a second base and a telescopic column arranged on an upper portion of the second base.

Abstract: A low-impact water conserving dam includes a dam body and reinforcing ribs arranged on a rear portion of the dam body. The reinforcing ribs comprise transverse reinforcing ribs and vertical reinforcing ribs interlaced with the transverse reinforcing ribs. A front portion of the dam body is an inclined surface and a rear end of the dam body is a platform surface. A planting bin is arranged on the platform surface of the dam body for planting vegetation. A plurality of water flow through holes are arranged in a matrix manner at a bottom of the planting bin. A water storage bin is arranged in an interior of the dam body. The water flow through holes are communicated with the water storage bin. A water drainage channel communicated with the water storage bin is formed in a middle upper portion of the inclined surface of the dam body.

Abstract: A municipal warning lamp includes control box and a warning lamp post arranged on an upper portion of the control box. The warning lamp post is of a cuboid structure. At least three warning lights with different colors are arranged on each side of the warning lamp post. A power supply, a controller, a temperature and humidity sensor, a network communication transmission unit, an alerter, a data memory, a first telescopic driving cylinder, a second telescopic driving cylinder, and a BLUETOOTH transmission unit are arranged in an interior of the control box.

Abstract: A water conserving gate includes a base and a gate board configured to resist external water flow. A first supporting column, a second supporting column and a third supporting column are sequentially arranged on an upper portion of the base. A control box is arranged on the upper portion of the base. A first connecting rod is connected between a gate board and the first supporting column; a second connecting rod is connected between the gate board and the second supporting column. A third connecting rod is connected between the gate board and the third supporting column. A first rotary boss arranged on the first supporting column is movably connected with the first connecting rod. A second rotary boss arranged on the second supporting column is movably connected with the second connecting rod.

Abstract: The municipal waste sorting system includes a sorting guide rail frame and garbage collecting boxes arranged on two sides of the sorting guide rail frame, a first recycling bin disposed on a tail of the soiling guide rail frame and a second recycling bin in communication with the first recycling bin. A garbage discharge pipe is connected with an end head portion of a front end of the sorting guide rail frame and discharges the garbage into the sorting guide rail frame. A guide rail assembly is arranged on an upper portion of the sorting guide rail flame to transport garbage. A first sorting manipulator assembly, a second sorting manipulator assembly and a third sorting manipulator assembly are arranged on the sorting guide rail frame to screen the garbage to the garbage collecting boxes.

Abstract: A water conserving, secure and environment protective device includes a stationary base, a reflux column connected with the stationary base and a floating mechanism assembly sleeved on the reflux column. The reflux column defining a plurality of reflux holes to reflux a water source. A water absorption mechanism assembly includes a plurality of supporting frames, a water pump arranged on an upper portion of the supporting frames, and a plurality of water suction pipes communicated with the water pump to suck an external source of water.

Abstract: A water conserving silt discharging device includes a moving bottom plate. A first material conveying water pump, a stirring box, a filler box and a compression box are sequentially arranged on an upper portion of the moving bottom plate. And a roller mechanism is arranged on each of four diagonal portions of a lower portion of the moving bottom palate. A controller, an infrared sensor and a high-definition camera assembly are arranged on the upper portion of the moving bottom plate. The first material conveying water pump conveys silt material to the stirring box through a convey pipe. A jitter mechanism assembly is arranged at a bottom portion of the stirring box to generate jittering. The jitter mechanism assembly comprises a plurality of identically shaking spring bodies and a driving cylinder arranged on the shaking spring bodies.

Abstract: The invention provides an intelligent moxibustion device, comprising a vertically disposed barrel, an ash tower buckled with the barrel, a moxa stick driving unit and an intelligent control unit disposed in the barrel; wherein the moxa stick driving unit comprises a moxa stick sleeve and a stepping motor disposed above the moxa stick sleeve; the stepping motor drives the moxa stick to move up and down through the transmission of a gear; the intelligent control unit comprises a battery disposed above the stepping motor for powering the entire moxibustion device, a circuit board fixed above the battery, and a temperature sensor disposed in the ash tower, the battery being connected to the circuit board to provide power to the circuit board, the circuit board being connected to the temperature sensor through input and output terminals.

Abstract: A mobile terminal unlock method for security protection is provided. The method includes: obtaining a trigger signal for unlock, and generating a first password according to the trigger signal; generating a corresponding unlock signal according to a preset correspondence between the unlock signal and the first password and with reference to the first password, and sending the corresponding unlock signal; obtaining an unlock password that is obtained by means of parsing by a user according to the unlock signal; matching the unlock password with the first password; determining whether the unlock password is consistent with the first password; and if a determining result is yes, unlocking a password lock; or if a determining result is no, obtaining a trigger signal for unlock again.

Abstract: The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.

Abstract: A mobile terminal unlock method is provided. The method includes: obtaining a trigger signal for unlock, and generating a first password according to the trigger signal; generating a corresponding unlock signal according to a preset correspondence between the unlock signal and the first password and with reference to the first password, and sending the corresponding unlock signal; obtaining an unlock password that is obtained by means of parsing by a user according to the unlock signal; matching the unlock password with the first password; determining whether the unlock password is consistent with the first password; and if a determining result is yes, unlocking a password lock; or if a determining result is no, obtaining a trigger signal for unlock again.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: A method for providing application service is provided. The method discloses that a user is authenticated according to a received application service acquisition request from a user mobile phone, and when the user authentication is passed, the application service acquisition request is sent to an application server, so that the application server provides an application service to the user mobile phone according to the application service acquisition request. The application server does not need to authenticate the user mobile phone by performing an authentication operation on the user mobile phone through a wireless application protocol gateway, thus being capable of reducing the workload of the application server.

Abstract: The present disclosure relates to a method for processing online user distribution. The method includes acquiring a map for displaying online user distribution; determining the projection algorithm of the map; determining intermediate coordinates of at least one of the points according to a longitude and a latitude and the projection algorithm, and acquiring, by using a fitting algorithm, approximate solutions of functions of mapping the intermediate coordinates to the coordinates on the map. The method further includes calculating coordinates of each online user on the map according to the projection algorithm and the approximate solutions of the mapping functions; and assembling distribution data of online users on the map according to coordinates of all the online users on the map. The present disclosure further provides an apparatus for processing online user distribution.

Abstract: Embodiments of the present invention disclose a flow control method and apparatus under an NFV architecture. The method includes: virtualizing a physical resource into multiple virtual resources that are used to independently run services, and dividing the physical resource into multiple sub physical resources, where there is a correspondence between the virtual resource and the sub physical resource; obtaining a preset mapping relationship between a service priority and the virtual resource, and setting a priority for the virtual resource according to the preset mapping relationship between the service priority and the virtual resource; and when a service traffic burst causes congestion of the physical resource, controlling, according to the priority of the virtual resource and the correspondence between the virtual resource and the sub physical resource, the sub physical resource that is used by the virtual resource.

Abstract: According to one aspect of the invention, a latch is configured to fix a panel relative to a frame. The latch includes a housing configured for engagement to the panel. The latch also includes a cap mounted within the housing and a shaft extending along a longitudinal axis within the housing. A spring of the latch is configured to bias the shaft away from the cap along the longitudinal axis, and a sleeve of the latch interposed between the shaft and the housing, the sleeve defining a first slot. The latch also includes a cam interposed between the shaft and the housing, the cam defining a second slot. A pin is provided which extends into the first and second slots. The first and second slots are configured to guide the rotation and axial movement of the shaft as the cap is rotated within the housing.