Abstract: The invention provides T cells comprising nucleic acid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell priming, compositions including the T cells, and methods of using the T cells to treat diseases associated with the expression of disease-associated antigens.

Abstract: A stroke decision device 30 includes an acquisition section 31 configured to acquire state information including a position, a velocity, and a rotational velocity of an incoming ball, and a stroke decision section 32 configured to decide a stroke condition including a position, a velocity, and an orientation of a striking implement at a time point when hitting back the ball toward a target arrival position, based on the state information for the ball and the target arrival position when hitting back the ball with the striking implement.

Abstract: Embodiments of this application disclose a method and a device for detecting network reliability. The method includes: A detection apparatus obtains a first quantity of data packets included in a first packet sent by a first network node to a second network node. The detection apparatus obtains first feedback information sent by the second network node, where the first feedback information includes a second quantity of data packets included in the first packet received by the second network node. The detection apparatus calculates communication service availability of a network channel from the first network node to the second network node based on at least one of the first quantity or the second quantity. Embodiments of this application can quickly and accurately detect and evaluate the network reliability.

Abstract: According to one aspect of the invention, a latch is configured to fix a panel relative to a frame. The latch includes a housing configured for engagement to the panel. The latch also includes a cap mounted within the housing and a shaft extending along a longitudinal axis within the housing. A spring of the latch is configured to bias the shaft away from the cap along the longitudinal axis, and a sleeve of the latch interposed between the shaft and the housing, the sleeve defining a first slot. The latch also includes a cam interposed between the shaft and the housing, the cam defining a second slot. A pin is provided which extends into the first and second slots. The first and second slots are configured to guide the rotation and axial movement of the shaft as the cap is rotated within the housing.

Abstract: A video encoding method is provided in the present invention. The method includes: determining a range of interest ROI in an ith frame, wherein the ROI comprises at least one ROI macroblock; extracting characteristic information of the at least one ROI macroblock, wherein the characteristic information comprises location information and type information of the at least one ROI macroblock; determining a quantization parameter QP corresponding to each of the at least one ROI macroblock; encoding the characteristic information of the at least one ROI macroblock according to the determined QP corresponding to each ROI macroblock, to obtain an ROI characteristic stream of the ith frame; and adding, to a video stream of the ith frame, the QP corresponding to each ROI macroblock and the ROI characteristic stream of the ith frame, to perform sending, wherein the video stream of the ith frame is obtained by encoding the ROI and a non-ROI comprised in the ith frame.

Abstract: The invention provides T cells comprising nucleic acid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell priming, compositions including the T cells, and methods of using the T cells to treat diseases associated with the expression of disease-associated antigens.

Abstract: The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.

Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.

Abstract: A silt filtering device includes a moving bottom plate. A first material conveying water pump, a stirring box, a filter box and a compression box are sequentially arranged on an upper portion of the moving bottom plate. A roller mechanism is arranged on each of four diagonal portions of a lower portion of the moving bottom plate. A controller, an infrared sensor and a high-definition camera assembly are arranged on the upper portion of the moving bottom plate. The first material conveying water pump conveys silt material to the stirring box through a convey pipe. A jitter mechanism assembly is arranged at a bottom portion of the stirring box to generate jittering. The jitter mechanism assembly comprises a plurality of identically shaking spring bodies and a driving cylinder arranged on the shaking spring bodies.

Abstract: The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.

Abstract: A video encoding method is provided in the present invention. The method includes: determining a range of interest ROI in an ith frame, wherein the ROI comprises at least one ROI macroblock; extracting characteristic information of the at least one ROI macroblock, wherein the characteristic information comprises location information and type information of the at least one ROI macroblock; determining a quantization parameter QP corresponding to each of the at least one ROI macroblock; encoding the characteristic information of the at least one ROI macroblock according to the determined QP corresponding to each ROI macroblock, to obtain an ROI characteristic stream of the ith frame; and adding, to a video stream of the ith frame, the QP corresponding to each ROI macroblock and the ROI characteristic stream of the ith frame, to perform sending, wherein the video stream of the ith frame is obtained by encoding the ROI and a non-ROI comprised in the ith frame.

Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof.

Abstract: The present invention includes compositions and methods for modifying a T cell with a nucleic acid encoding a switch molecule comprising an extracellular domain comprising a membrane receptor or fragment thereof and an intracellular domain comprising a signaling receptor or fragment thereof. In one aspect, a method comprises introducing a nucleic acid encoding a switch molecule and a nucleic acid encoding a soluble fusion protein and/or a nucleic acid encoding a bispecific antibody into a population of cells comprising T cells, wherein the T cells transiently expresses the switch molecule and soluble fusion protein or bispecific antibody. In other aspect, compositions of T cells and methods of treating a disease or condition, such as cancer or an autoimmune disease, are also included.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: The present invention includes compositions and methods for modifying a T cell with a nucleic acid encoding a switch molecule comprising an extracellular domain comprising a membrane receptor or fragment thereof and an intracellular domain comprising a signaling receptor or fragment thereof. In one aspect, a method comprises introducing a nucleic acid encoding a switch molecule and a nucleic acid encoding a soluble fusion protein and/or a nucleic acid encoding a bispecific antibody into a population of cells comprising T cells, wherein the T cells transiently expresses the switch molecule and soluble fusion protein or bispecific antibody. In other aspect, compositions of T cells and methods of treating a disease or condition, such as cancer or an autoimmune disease, are also included.

Abstract: A mobile terminal with unlock function is provided.

Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.

Abstract: The present disclosure relates to a method for processing online user distribution. The method includes acquiring a map for displaying online user distribution; determining the projection algorithm of the map; determining intermediate coordinates of at least one of the points according to a longitude and a latitude and the projection algorithm, and acquiring, by using a fitting algorithm, approximate solutions of functions of mapping the intermediate coordinates to the coordinates on the map. The method further includes calculating coordinates of each online user on the map according to the projection algorithm and the approximate solutions of the mapping functions; and assembling distribution data of online users on the map according to coordinates of all the online users on the map. The present disclosure further provides an apparatus for processing online user distribution.

Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.