Abstract: Methods, software programs and systems for extending and modifying software functionality, and, more particularly, for using one or more patterns for an enterprise software object to express desired functionality and configuration, and to generate the enterprise software object using the patterns, in an enterprise environment are disclosed. A method according to certain of these embodiments includes selecting one or more patterns from a number of patterns, where the one or more patterns are for an enterprise software object. The enterprise software object can then be generated. The enterprise software object is generated using the one or more patterns. Each of the patterns is configured to describe a solution within a corresponding one of a number of problem domains.

Abstract: Pyrazole urea compounds, pharmaceutical compositions which contain them and methods for treating cancer using them.

Abstract: Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.