Patents by Inventor Xiaoming Zhou
Xiaoming Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8481743Abstract: The invention relates to phenylpropionamide compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A, B, R1, R2, R3, R4 and R5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the activation of opioid receptors, particularly ?-opioid receptors. Compounds of the present invention are especially useful for treating pain.Type: GrantFiled: October 31, 2007Date of Patent: July 9, 2013Assignee: Purdue Pharma L.P.Inventor: Xiaoming Zhou
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Patent number: 8354434Abstract: The invention relates to cyclourea compounds of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.Type: GrantFiled: January 15, 2007Date of Patent: January 15, 2013Assignee: Purdue Pharma L.P.Inventor: Xiaoming Zhou
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Patent number: 8349842Abstract: Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.Type: GrantFiled: July 20, 2009Date of Patent: January 8, 2013Assignee: Purdue Pharma, L.P.Inventors: Qun Sun, Kate Xin Wen, Xiaoming Zhou
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Publication number: 20120322830Abstract: The invention relates to cyclourea compounds of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.Type: ApplicationFiled: June 11, 2012Publication date: December 20, 2012Applicant: Purdue Pharma L.P.Inventor: Xiaoming ZHOU
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Patent number: 8314232Abstract: The present invention relates to a process of preparing a compound of the following formula III: wherein R1-R4 are as defined herein. The present invention also relates to the preparation of intermediates used to prepare the compound of formula III.Type: GrantFiled: September 25, 2009Date of Patent: November 20, 2012Assignee: GlaxoSmithKline LLCInventors: Nicole Marie Deschamps, Michael Tolar Martin, Michael John Monteith, Xiaoming Zhou
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Publication number: 20110281885Abstract: A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.Type: ApplicationFiled: September 10, 2010Publication date: November 17, 2011Applicant: Purdue Pharma L.P.Inventors: Donald J. Kyle, Qun Sun, Laykea Tafesse, Chongwu Zhang, Xiaoming Zhou
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Patent number: 8058292Abstract: The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.Type: GrantFiled: May 24, 2010Date of Patent: November 15, 2011Assignee: Purdue Pharma L.P.Inventors: Donald J. Kyle, Qun Sun, Xiaoming Zhou
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Publication number: 20110227824Abstract: A method of providing immersive effects includes receiving data representative of at least one image. The image data is analyzed to locate at least one object identified within the image. A visual focus of attention of at least one subject able to observe the at least one image is estimated. At least one signal is provided in dependence on at least a position of the visual focus of attention relative to the location of the at least one object in the 5 at least one image to a system (16-19; 31-34) for providing an immersive effect to the at least one subject.Type: ApplicationFiled: November 18, 2009Publication date: September 22, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Xiaoming Zhou, Andrew A. Tokmakoff
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Publication number: 20110082152Abstract: A compound of formula: wherein Ar, Ar1, Ar2, R3, R4, R5, R6, R13, m, t, and x are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.Type: ApplicationFiled: November 10, 2010Publication date: April 7, 2011Applicant: Purdue Pharma L.P.Inventors: Qun Sun, Xiaoming Zhou
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Publication number: 20110022992Abstract: The invention relates to a method for modifying a representation based upon a user instruction and a system for producing a modified representation by said method. Conventional drawing systems, such as pen and paper and writing tablets, require a reasonable degree of drawing skill which not all users possess. Additionally, these conventional systems produce static drawings. The method of the invention comprises receiving a representation from a first user, associating the representation with an input object classification, receiving an instruction from a second user, associating the instruction with an animation classification, determining a modification of the representation using the input object classification and the animation classification, and modifying the representation using the modification. When the first user provides a representation of something, for example a character in a story, it is identified to a certain degree by associating it with an object classification.Type: ApplicationFiled: March 24, 2009Publication date: January 27, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Xiaoming Zhou, Paul Marcel Carl Lemmens, Alphons Antonius Maria Lambertus Bruekers, Andrew Alexander Tokmakoff, Evelijne Machteld Hart De Ruijter-Bekker, Serverius Petrus Paulus Pronk
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Patent number: 7855210Abstract: A compound of formula: wherein Ar, Ar1, Ar2, R3, R4, R5, R6, R13, m, t, and x are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.Type: GrantFiled: September 29, 2008Date of Patent: December 21, 2010Assignee: Purdue Pharma, L.P.Inventors: Qun Sun, Xiaoming Zhou
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Patent number: 7826860Abstract: A device and method for of synchronizing a MAC superframe of a wireless device is disclosed. The wireless device can be located within a chain of a plurality of other wireless devices. The method includes receiving beacons from at least one other device during a superframe of the wireless device, determining a superframe offset for each of the other wireless devices based on timing of the received beacons, determining a corrective delay based on the superframe offsets, inserting the corrective delay within a current superframe of the wireless device, and inserting a predictive delay within the current superframe, the predictive delay being determined by an estimate of a difference between a frequency a clock of the wireless device and a frequency of a slowest clock of the other wireless devices within the chain.Type: GrantFiled: September 4, 2008Date of Patent: November 2, 2010Assignee: NDSSI Holdings, LLCInventors: Patrick Worfolk, Xiaoming Zhou
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Patent number: 7827459Abstract: The present invention relates to an improved communications protocol which increases the efficiency of transmission in return channels on a multi-channel slotted Alohas system by incorporating advanced error correction algorithms, selective retransmission protocols and the use of reserved channels to satisfy the retransmission requests.Type: GrantFiled: January 8, 2007Date of Patent: November 2, 2010Assignee: University of Maryland, College ParkInventors: Xiaoming Zhou, John S. Baras
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Publication number: 20100256111Abstract: The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.Type: ApplicationFiled: May 24, 2010Publication date: October 7, 2010Applicant: Purdue Pharma L.P.Inventors: Donald J. Kyle, Qun Sun, Xiaoming Zhou
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Patent number: 7799786Abstract: A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.Type: GrantFiled: September 4, 2007Date of Patent: September 21, 2010Assignee: Purdue Pharma L.P.Inventors: Donald J. Kyle, Qun Sun, Laykea Tafesse, Chongwu Zhang, Xiaoming Zhou
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Publication number: 20100234426Abstract: The invention relates to phenylpropionamide compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A, B, R1, R2, R3, R4 and R5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the activation of opioid receptors, particularly ?-opioid receptors. Compounds of the present invention are especially useful for treating pain.Type: ApplicationFiled: October 31, 2007Publication date: September 16, 2010Applicant: Purdue Pharma L.P.Inventor: Xiaoming Zhou
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Publication number: 20100210686Abstract: Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.Type: ApplicationFiled: July 20, 2009Publication date: August 19, 2010Applicant: Purdue Pharma L.P.Inventors: Qun Sun, Kate Xin Wen, Xiaoming Zhou
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Patent number: 7767699Abstract: The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.Type: GrantFiled: December 22, 2005Date of Patent: August 3, 2010Assignee: Purdue Pharma, L.P.Inventors: Donald J. Kyle, Qun Sun, Xiaoming Zhou
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Patent number: 7737148Abstract: A compound of formula: wherein Ar, Ar1, Ar2, R3-R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.Type: GrantFiled: November 16, 2006Date of Patent: June 15, 2010Assignee: Purdue Pharma, L.P.Inventors: Qun Sun, Xiaoming Zhou
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Publication number: 20100098047Abstract: Embodiments for setting a data rate of encoded data of a transmitter are disclosed. One method includes determining a physical layer transmission rate based on a transmission link quality of a link, estimating a transmission throughput that can be transmitted over the link ensuring a level of Quality of Service (QOS) requirement, and the transmitter adjusting the data rate of the encoded data based on the estimated transmission throughput.Type: ApplicationFiled: October 21, 2008Publication date: April 22, 2010Inventors: Xiaoming Zhou, Patrick Worfolk, Sujai Chari