Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

Abstract: An intelligent tray for chips includes a main body having a readable and writable memory unit thereon. The readable and writable memory unit has parameters related to the intelligent tray written therein. The parameters written in the readable and writable memory unit can be read out automatically by a machine, and no need to be manually checked one by one. This helps to automate production, improve production efficiency and shorten production cycle.

Abstract: The disclosed method calculates video time density functions based on inter-frame mutual information or other similarity measures. The method includes acquiring a video sequence from memory, computing mutual information or other similarity measures between two consecutive frames of the video sequence, and constructing a video temporal density function based on the mutual information or similarity measures. The method enables fast navigation of the video sequence by performing a temporal quantization of the video time density function to determine a set of quanta. The video sequence can be navigated using the nearest neighbor video frames to the set of quanta. The method enables thumbnail extraction of a video sequence using statistical modeling by performing a temporal quantization of the video time density function to segment video sequence in time domain and using mixture (such as Gaussian mixture and ICA mixture) vector quantization to find the sample frames for each temporal segment.

Abstract: The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.

Abstract: A manufacturing process of a heat-exchange assembly of a water heater bottom cover is disclosed.

Abstract: Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis.

Abstract: The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.

Abstract: This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.

Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

Abstract: A method for automatically switching scene mode and a portable terminal are disclosed, the method comprises steps of setting life cycle and subsequent scene mode for each scene mode; judging whether the life cycle of current scene mode has ended; and switching the current scene mode to a subsequent scene mode if it is judged that the life cycle of the current scene mode has ended. With the present invention, a user can define desired scene modes at different moments during a day depending on his daily arrangement, and thus this brings great convenience to the user.

Abstract: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.

Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

Abstract: A skin-whitening, freckle-removing cosmetic composition, comprising an effective amount of extract from Cistanche deserticola and other useful adjuvants.

Abstract: The present invention is directed to a sequence dependent polynucleotide nanomechanical device based on a nucleic acid paranemic crossover (PX) molecule which is a four-stranded structure related to parallel double crossover molecules, except that every possible crossover takes place. Eliminating two crossovers leads to a topoisomer, termed JX2, in which one pair of ends are switched (rotated 180°) while the other pair of ends remain the same. The device can be cycled between the two states, PX and JX2, by replacing single strands that set the state to be PX or JX2.

Abstract: Robust nucleic acid arrays and lattices are assembled based on double crossover cohesion of polygonal units whose edges are composed of nucleic acid multi-crossover domains.

Abstract: A system having a mobile terminal used as an input/output device of a computer is disclosed. The system may comprise a mobile terminal side audio input/output unit, a mobile terminal side sending/receiving unit, a computer side sending/receiving unit and a computer side virtual audio driving unit, wherein, the mobile terminal side audio input unit is adapted to collect audio data; the mobile terminal side audio output unit is adapted to play the audio data; the computer side virtual audio driving unit is adapted to have the mobile terminal used as the input/output device of the computer. A mobile terminal, a computer, and a method for the system are also disclosed. It is possible to, with an existing mobile terminal, directly have the mobile terminal virtualized as the input/output device of the computer by using the system of the present invention and the mobile terminal, the computer and the method thereof, so that users may use the mobile terminal to initiate and receive VoIP calls.

Abstract: A network projection system and method are disclosed, the system comprises announcement means for announcing virtual network projection device information over a network and receiving a projection request from at least one network projection source, projection data receiving means for receiving data used in projection from the at least one network projection source, processing means for processing the data received from the at least one network projection source to meet a user's requirement, and projection data displaying means for displaying the processed projection data on a connected display device or transmitting the processed projection data to another network projection device over the network. With the structure of the present invention, a common display device can be virtualized as a network projection device to facilitate simultaneous display of projection contents from multiple projection sources on the same screen or switching of display via the network.

Abstract: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.

Abstract: A method for automatically switching scene mode and a portable terminal are disclosed, the method comprises steps of setting life cycle and subsequent scene mode for each scene mode; judging whether the life cycle of current scene mode has ended; and switching the current scene mode to a subsequent scene mode if it is judged that the life cycle of the current scene mode has ended. With the present invention, a user can define desired scene modes at different moments during a day depending on his daily arrangement, and thus this brings great convenience to the user.

Abstract: A method and an apparatus for processing user's files, by categorizing user's files and for generating a personal working set. Categorizing user's files is done by capturing history information about the user's operations on files; clustering the files operated by the user to generate one or more categories based on the captured history information and at least one predefined file relationship. User's history of operations on files as well as file relationships implied during user's operation can be reflected by the generated categories.