Abstract: A monoclonal antibody specifically binding to human and monkey CD38 antigens or a derivative thereof includes: antigen complementarity-determining regions CDR1, CDR2 and CDR3 of an antibody light chain variable region having amino acid sequences as set forth in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; and antigen complementarity-determining regions CDR1, CDR2 and CDR3 of an antibody heavy chain variable region having amino acid sequences as set forth in SEQ ID NO: 8, SEQ ID NO: 9 and SEQ ID NO: 10, respectively. The monoclonal antibody or derivative thereof can be used as a component of a pharmaceutical composition or prepared into a suitable pharmaceutical preparation, administered alone or combined with other therapeutic means such as chemotherapy drugs, for treating tumors with positive CD38 expression, such as human myeloma and human lymphoma.

Abstract: Disclosed is a joint recommendation and cache optimization method based on a collaboration of multiple base stations, each base station in a target area randomly caching contents stored to the cloud, when each base station in the target area receives a to-be-responded content request, constructing the recommendation optimization sub-model, the access optimization sub-model and the cache optimization sub-model, then constructing and solving the optimization problem to obtain the target base station, optimal cached contents and the recommendation list that correspond to the to-be-responded content request. Through the technical solution of the present application, the total time delay of the system is minimized, and by jointly optimizing the recommendation decision, access decision and cache decision, the delay can be significantly reduced with a lower cache capacity, and more efficient for users, good experience.

Abstract: Disclosed is a joint recommendation and cache optimization method based on a collaboration of multiple base stations, each base station in a target area randomly caching contents stored to the cloud, when each base station in the target area receives a to-be-responded content request, constructing the recommendation optimization sub-model, the access optimization sub-model and the cache optimization sub-model, then constructing and solving the optimization problem to obtain the target base station, optimal cached contents and the recommendation list that correspond to the to-be-responded content request. Through the technical solution of the present application, the total time delay of the system is minimized, and by jointly optimizing the recommendation decision, access decision and cache decision, the delay can be significantly reduced with a lower cache capacity, and more efficient for users, good experience.

Abstract: The present disclosure relates to a compound of formulae (I) or (II), or a pharmaceutically acceptable salt, a solvate, a hydrate thereof, a pharmaceutical composition comprising a compound of formulae (I) or (II), and use thereof, wherein various Markush groups are as described herein.

Abstract: The present disclosure relates to a compound of formula (I), or a pharmaceutically acceptable salt, a solvate, a stereoisomer, or tautomer thereof, a pharmaceutical composition comprising a compound of formula (A) or formula (B), and any subgenera thereof, and use of said compounds and compositions thereof, wherein R1, R2, R3a, R3b, R5, R6, X1, X2, Y and n are described herein.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The present disclosure relates to novel opioid receptor modulator compounds. Pharmaceutical compositions comprising such buprenorphine analog compound are also disclosed, and the use of such compound in the treatment of visceral hyperalgesia, diarrhea-predominant irritable bowel syndrome, and short bowel syndrome. The opioid receptor modulator compounds of the disclosure include Compound D.

Abstract: A full-automatic rock specimen image acquisition device and method, the device includes a central controller and a lighting system, a rock mass attitude control system, a dust system and an image acquisition system connected to the central controller respectively; the lighting system includes a lighting chamber and light sources with adjustable light intensities, and the light sources with adjustable light intensities are uniformly arranged in the lighting chamber; the rock mass attitude control system includes a rotating stage disposed in the lighting chamber for carrying the rock, a rock holder disposed on the stage, and a rotating gripper disposed above the stage for turning over the rock; and the dust system is connected to the lighting chamber, and can diffuse the dust into the lighting chamber through an air compressor and control the dust concentration in the lighting chamber through an electrostatic precipitator.

Abstract: Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.

Abstract: Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.

Abstract: A full-automatic rock specimen image acquisition device and method, the device includes a central controller and a lighting system, a rock mass attitude control system, a dust system and an image acquisition system connected to the central controller respectively; the lighting system includes a lighting chamber and light sources with adjustable light intensities, and the light sources with adjustable light intensities are uniformly arranged in the lighting chamber; the rock mass attitude control system includes a rotating stage disposed in the lighting chamber for carrying the rock, a rock holder disposed on the stage, and a rotating gripper disposed above the stage for turning over the rock; and the dust system is connected to the lighting chamber, and can diffuse the dust into the lighting chamber through an air compressor and control the dust concentration in the lighting chamber through an electrostatic precipitator.

Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Methods, systems, and computer-readable media for measuring packet delays are provided. An input port of a network device is tapped to duplicate an input packet stream having a first packet. An output port of the network device is tapped to duplicate an output packet stream including the first packet. The duplicated input packet stream and the duplicated output packet stream is transmitted to a programmable device. The first packet in the first input packet stream is matched to the first packet in the first output packet stream. An arrival time and a departure time for the first packet is measured. The difference between the departure time of the first packet and the arrival time of the first packet is determined and the value is reported to an external collector.

Abstract: The present disclosure relates to a compound of formula (I), or a pharmaceutically acceptable salt, a solvate, a stereoisomer, or tautomer thereof, a pharmaceutical composition comprising a compound of formula (A) or formula (B), and any subgenera thereof, and use of said compounds and compositions thereof, wherein R1, R2, R3a, R3b, R5, R6, X1, X2, Y and n are described herein.

Abstract: The present disclosure relates to a compound of formulae (I) or (II), or a pharmaceutically acceptable salt, a solvate, a hydrate thereof, a pharmaceutical composition comprising a compound of formulae (I) or (II), and use thereof, wherein various Markush groups are as described herein.

Abstract: Methods, systems, and computer-readable media for measuring packet delays are provided. An input port of a network device is tapped to duplicate an input packet stream having a first packet. An output port of the network device is tapped to duplicate an output packet stream including the first packet. The duplicated input packet stream and the duplicated output packet stream is transmitted to a programmable device. The first packet in the first input packet stream is matched to the first packet in the first output packet stream. An arrival time and a departure time for the first packet is measured. The difference between the departure time of the first packet and the arrival time of the first packet is determined and the value is reported to an external collector.

Abstract: Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.

Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.

Abstract: A cornfield herbicidal composition comprising pyrazolone compounds and an application thereof is provided. The cornfield herbicidal composition comprises an herbicidally effective amount of an active ingredient A, an active ingredient B, and a safener compound C, wherein the active ingredient A is a compound of the formula (I); the active ingredient B is selected from one or more of the following compounds: triazines, nitriles, sulfonylureas, pyridine carboxylic acids, benzyl carboxylic acids, bentazone, amides, pyridines and amicarbazone; and the safener compound C is selected from one or more of the following compounds: C1 isoxadifen-ethyl, C2 cyprosulfamide, C3 mefenpyr-diethyl, C4 cloquintocet-mexyl, C5 gibberellic acid, C6 furilazole and C7 N-(2-methoxybenzoyl)-4-[(methylaminocarbonyl)amino]benzenesulfonamide.